Combinatorial control of muscle development by basic helix-loop-helix and MADS-box transcription factors.

Interactions between heterologous helix-loop-helix proteins generate complexes that bind specifically to a common DNA sequence

1989 • 1,876 citations

The myoD Gene Family: Nodal Point During Specification of the Muscle Cell Lineage

1991 • 1,564 citations

Muscle deficiency and neonatal death in mice with a targeted mutation in the myogenin gene

1993 • 1,314 citations

Conversion of Xenopus Ectoderm into Neurons by NeuroD, a Basic Helix-Loop-Helix Protein

1995 • 1,028 citations

Functional activity of myogenic HLH proteins requires hetero-oligomerization with E12/E47-like proteins in vivo

1991 • 874 citations

Cooperative activation of muscle gene expression by MEF2 and myogenic bHLH proteins

1995 • 817 citations

The MyoD DNA binding domain contains a recognition code for muscle-specific gene activation

1990 • 794 citations

The MADS-Box Family of Transcription Factors

1995 • 780 citations

MyoD family: a paradigm for development?

1990 • 776 citations

Ternary complex factors: growth factor regulated transcriptional activators

1994 • 686 citations

bHLH factors in muscle development: dead lines and commitments, what to leave in and what to leave out.

1994 • 686 citations

Identification of a New Family of Tissue-Specific Basic Helix-Loop-Helix Proteins with a Two-Hybrid System

1995 • 655 citations

A regulatory hierarchy for cell specialization in yeast

1989 • 612 citations

A new myocyte-specific enhancer-binding factor that recognizes a conserved element associated with multiple muscle-specific genes.

1989 • 605 citations

Mef2 gene expression marks the cardiac and skeletal muscle lineages during mouse embryogenesis

1994 • 553 citations

A Subclass of bHLH Proteins Required for Cardiac Morphogenesis

1995 • 544 citations

Requirement of MADS Domain Transcription Factor D-MEF2 for Muscle Formation in Drosophila

1995 • 502 citations

Human myocyte-specific enhancer factor 2 comprises a group of tissue-restricted MADS box transcription factors.

1992 • 491 citations

The intracellular domain of mouse Notch: a constitutively activated repressor of myogenesis directed at the basic helix-loop-helix region of MyoD

1994 • 483 citations

Crystal structure of MyoD bHLH domain-DNA complex: Perspectives on DNA recognition and implications for transcriptional activation

1994 • 448 citations

Human SRF-related proteins: DNA-binding properties and potential regulatory targets.

1991 • 446 citations

The MyoD family of transcription factors and skeletal myogenesis

1995 • 441 citations

Drosophila MEF2, a transcription factor that is essential for myogenesis.

1995 • 426 citations

HLH proteins, fly neurogenesis, and vertebrate myogenesis

1993 • 420 citations

The regulation of myogenin gene expression during the embryonic development of the mouse.

1993 • 419 citations

Regulatory mechanisms that coordinate skeletal muscle differentiation and cell cycle withdrawal

1994 • 348 citations

Regulation of Muscle Differentiation by the MEF2 Family of MADS Box Transcription Factors

1995 • 348 citations

Muscle-specific transcriptional activation by MyoD.

1991 • 347 citations

Structure of serum response factor core bound to DNA

1995 • 340 citations

Muscle-specific expression of the cardiac alpha-actin gene requires MyoD1, CArG-box binding factor, and Sp1.

1990 • 334 citations

FGF inactivates myogenic helix-loop-helix proteins through phosphorylation of a conserved protein kinase C site in their DNA-binding domains

1992 • 333 citations

Hxt encodes a basic helix-loop-helix transcription factor that regulates trophoblast cell development

1995 • 321 citations

Human and Drosophila Homeodomain Proteins That Enhance the DNA-Binding Activity of Serum Response Factor

1992 • 314 citations

HEB, a helix-loop-helix protein related to E2A and ITF2 that can modulate the DNA-binding ability of myogenic regulatory factors.

1992 • 312 citations

Analysis of the myogenin promoter reveals an indirect pathway for positive autoregulation mediated by the muscle-specific enhancer factor MEF-2.

1992 • 302 citations

Helix-loop-helix proteins as regulators of muscle-specific transcription.

1993 • 293 citations

Making muscle in mammals

1992 • 292 citations

Expression of mef2 genes in the mouse central nervous system suggests a role in neuronal maturation

1995 • 274 citations

Myocyte enhancer factor (MEF) 2C: a tissue-restricted member of the MEF-2 family of transcription factors.

1993 • 267 citations

Myogenin induces the myocyte-specific enhancer binding factor MEF-2 independently of other muscle-specific gene products.

1991 • 264 citations

Separable Regulatory Elements Governing myogenin Transcription in Mouse Embryogenesis

1993 • 258 citations

Fos and Jun repress transcriptional activation by myogenin and MyoD: the amino terminus of Jun can mediate repression.

1992 • 250 citations

Identification of upstream and intragenic regulatory elements that confer cell-type-restricted and differentiation-specific expression on the muscle creatine kinase gene.

1988 • 248 citations

Expression of a MyoD family member prefigures muscle pattern in Drosophila embryos.

1990 • 243 citations

hMEF2C gene encodes skeletal muscle- and brain-specific transcription factors.

1993 • 234 citations

MEF2C, a MADS/MEF2-family transcription factor expressed in a laminar distribution in cerebral cortex.

1993 • 234 citations

D-MEF2: a MADS box transcription factor expressed in differentiating mesoderm and muscle cell lineages during Drosophila embryogenesis.

1994 • 225 citations

A fourth human MEF2 transcription factor, hMEF2D, is an early marker of the myogenic lineage

1993 • 224 citations

Activation of the Myogenic Lineage by MEF2A, a Factor that Induces and Cooperates with MyoD

1994 • 223 citations

A Mef2 gene that generates a muscle-specific isoform via alternative mRNA splicing.

1994 • 218 citations

Paired MyoD-binding sites regulate myosin light chain gene expression.

1991 • 216 citations

Deficiency in Rhabdomyosarcomas of a Factor Required for MyoD Activity and Myogenesis

1993 • 215 citations

Mutational Analysis of the DNA Binding, Dimerization, and Transcriptional Activation Domains of MEF2C

1996 • 203 citations

Functional heterogeneity of mammalian TATA-box sequences revealed by interaction with a cell-specific enhancer

1990 • 193 citations

Regulatory Role of MEF2D in Serum Induction of the c-jun Promoter

1995 • 176 citations

A MyoD1-independent muscle-specific enhancer controls the expression of the beta-myosin heavy chain gene in skeletal and cardiac muscle cells.

1991 • 175 citations

D-mef2: a Drosophila mesoderm-specific MADS box-containing gene with a biphasic expression profile during embryogenesis.

1994 • 171 citations

Mutagenesis of the myogenin basic region identifies an ancient protein motif critical for activation of myogenesis.

1991 • 159 citations

A New Myocyte-Specific Enhancer-Binding Factor That Recognizes a Conserved Element Associated with Multiple Muscle-Specific Genes

1989 • 154 citations

Myogenin and MEF2 Function Synergistically To Activate the MRF4 Promoter during Myogenesis

1995 • 151 citations

Acquisition of myogenic specificity by replacement of three amino acid residues from MyoD into E12

1992 • 147 citations

A conserved 28-base-pair element (HF-1) in the rat cardiac myosin light-chain-2 gene confers cardiac-specific and alpha-adrenergic-inducible expression in cultured neonatal rat myocardial cells.

1991 • 144 citations

Multiple regulatory elements contribute differentially to muscle creatine kinase enhancer activity in skeletal and cardiac muscle.

1993 • 143 citations

Myosin light chain-2 luciferase transgenic mice reveal distinct regulatory programs for cardiac and skeletal muscle-specific expression of a single contractile protein gene.

1992 • 137 citations

The Drosophila homologue of vertebrate myogenic-determination genes encodes a transiently expressed nuclear protein marking primary myogenic cells.

1991 • 136 citations

MEF2B Is a Potent Transactivator Expressed in Early Myogenic Lineages

1996 • 135 citations

Myocyte-specific enhancer-binding factor (MEF-2) regulates alpha-cardiac myosin heavy chain gene expression in vitro and in vivo.

1993 • 132 citations

Cell-type-specific transcription in yeast

1991 • 125 citations

A ubiquitous factor (HF-1a) and a distinct muscle factor (HF-1b/MEF-2) form an E-box-independent pathway for cardiac muscle gene expression.

1992 • 123 citations

A novel myogenic regulatory circuit controls slow/cardiac troponin C gene transcription in skeletal muscle.

1994 • 113 citations

Drosophila MEF2 is regulated by twist and is expressed in both the primordia and differentiated cells of the embryonic somatic, visceral and heart musculature

1995 • 113 citations

The basic region of myogenin cooperates with two transcription activation domains to induce muscle-specific transcription.

1992 • 110 citations

Characterization of a promoter element required for transcription in myocardial cells.

1991 • 109 citations

Myocyte Enhancer Binding Factor-2 Expression and Activity in Vascular Smooth Muscle Cells

1996 • 106 citations

A common factor regulates skeletal and cardiac alpha-actin gene transcription in muscle.

1988 • 102 citations

Two nuclear factors compete for the skeletal muscle actin promoter.

1987 • 102 citations

Cyclic amplification and selection of targets for multicomponent complexes: myogenin interacts with factors recognizing binding sites for basic helix-loop-helix, nuclear factor 1, myocyte-specific enhancer-binding factor 2, and COMP1 factor.

1992 • 100 citations

DNA Binding Specificity Determinants in MADS-Box Transcription Factors

1995 • 98 citations

An E box in the desmin promoter cooperates with the E box and MEF-2 sites of a distal enhancer to direct muscle-specific transcription.

1994 • 96 citations

The RSRF/MEF2 protein SL1 regulates cardiac muscle-specific transcription of a myosin light-chain gene in Xenopus embryos.

1994 • 94 citations

The Mouse MRF4 Promoter Is trans-Activated Directly and Indirectly by Muscle-specific Transcription Factors

1995 • 93 citations

Expression of the D-MEF2 transcription in the Drosophila brain suggests a role in neuronal cell differentiation.

1996 • 90 citations

Repression of myogenin function by TGF-beta 1 is targeted at the basic helix-loop-helix motif and is independent of E2A products.

1992 • 88 citations

HEB, a Helix-Loop-Helix Protein Related to E2A and ITF2 That Can Modulate the DNA-Binding Ability of Myogenic Regulatory Factors

1992 • 86 citations

Identification of Upstream and Intragenic Regulatory Elements That Confer Cell-Type-Restricted and Differentiation-Specific Expression on the Muscle Creatine Kinase Gene

1988 • 86 citations

Analysis of the Myogenin Promoter Reveals an Indirect Pathway for Positive Autoregulation Mediated by the Muscle-Specific Enhancer Factor MEF-2

1992 • 82 citations

The basic helix-loop-helix protein upstream stimulating factor regulates the cardiac ventricular myosin light-chain 2 gene via independent cis regulatory elements.

1994 • 79 citations

α-myosin Heavy Chain Gene Regulation: Delineation and Characterization of the Cardiac Muscle-specific Enhancer and Muscle-specific Promoter

1996 • 78 citations

Promoter upstream elements of the chicken cardiac myosin light-chain 2-A gene interact with trans-acting regulatory factors for muscle-specific transcription.

1989 • 76 citations

Heterodimers of myogenic helix-loop-helix regulatory factors and E12 bind a complex element governing myogenic induction of the avian cardiac alpha-actin promoter.

1991 • 74 citations

EFI_A/YB-1 Is a Component of Cardiac HF-1A Binding Activity and Positively Regulates Transcription of the Myosin Light-Chain 2v Gene

1995 • 70 citations

Myogenin Induces the Myocyte-Specific Enhancer Binding Factor MEF-2 Independently of Other Muscle-Specific Gene Products

1991 • 67 citations

Binding of TFIID and MEF2 to the TATA element activates transcription of the Xenopus MyoDa promoter.

1994 • 66 citations

hMEF2C Gene Encodes Skeletal Muscle- and Brain-Specific Transcription Factors

1993 • 65 citations

Positive Regulatory Elements (HF-1a and HF-1b) and a Novel Negative Regulatory Element (HF-3) Mediate Ventricular Muscle-Specific Expression of Myosin Light-Chain 2-Luciferase Fusion Genes in Transgenic Mice

1994 • 64 citations

The myogenin gene is activated during myocyte differentiation by pre-existing, not newly synthesized transcription factor MEF-2.

1994 • 63 citations

A single MEF-2 site is a major positive regulatory element required for transcription of the muscle-specific subunit of the human phosphoglycerate mutase gene in skeletal and cardiac muscle cells.

1992 • 63 citations

Synergistic Interactions between Heterologous Upstream Activation Elements and Specific TATA Sequences in a Muscle-Specific Promoter

1995 • 63 citations

Muscle-specific expression of the acetylcholine receptor alpha-subunit gene requires both positive and negative interactions between myogenic factors, Sp1 and GBF factors.

1993 • 62 citations

The four human muscle regulatory helix-loop-helix proteins Myf3-Myf6 exhibit similar hetero-dimerizartion and DNA binding properties

1991 • 60 citations

The identification of elements determining the different DNA binding specificities of the MADS box proteins p67^SRFand RSRFC4

1993 • 59 citations

Structural Characterization and Regulatory Element Analysis of the Heart Isoform of Cytochrome c Oxidase VIa

1995 • 57 citations

Serum Induction of MEF2/RSRF Expression in Vascular Myocytes Is Mediated at the Level of Translation

1995 • 55 citations

A Mef2 Gene That Generates a Muscle-Specific Isoform via Alternative mRNA Splicing

1994 • 55 citations

Co-operativity of functional domains in the muscle-specific transcription factor Myf-5.

1992 • 48 citations

The MEF-3 Motif is Required for MEF-2-Mediated Skeletal Muscle-Specific Induction of the Rat Aldolase A Gene

1993 • 47 citations

Characterization of cis-regulating elements and trans-activating factors of the rat cardiac troponin T gene.

1994 • 45 citations

MEF2 proteins, including MEF2A, are expressed in both muscle and non-muscle cells

1995 • 44 citations

Myogenic Regulatory Factors Can Activate TATA-containing Promoter Elements via an E-Box Independent Mechanism

1995 • 44 citations

Activation of Xenopus MyoD Transcription by Members of the MEF2 Protein Family

1994 • 40 citations

The human skeletal alpha-actin gene is regulated by a muscle-specific enhancer that binds three nuclear factors.

1992 • 39 citations

A Common Factor Regulates Skeletal and Cardiac α-Actin Gene Transcription in Muscle

1988 • 31 citations

The Basic Region of Myogenin Cooperates with Two Transcription Activation Domains To Induce Muscle-Specific Transcription

1992 • 31 citations

Multiple Regulatory Elements Contribute Differentially to Muscle Creatine Kinase Enhancer Activity in Skeletal and Cardiac Muscle

1993 • 31 citations

A Novel Myogenic Regulatory Circuit Controls Slow/Cardiac Troponin C Gene Transcription in Skeletal Muscle

1994 • 29 citations

Developmental potential of muscle cell progenitors and the myogenic factor SUM-1 in the sea urchin embryo

1993 • 27 citations

A Conserved 28-Base-Pair Element (HF-1) in the Rat Cardiac Myosin Light-Chain-2 Gene Confers Cardiac-Specific and α-Adrenergic-Inducible Expression in Cultured Neonatal Rat Myocardial Cells

1991 • 27 citations

A Ubiquitous Factor (HF-la) and a Distinct Muscle Factor (HF-lb/MEF-2) Form an E-Box-Independent Pathway for Cardiac Muscle Gene Expression

1992 • 25 citations

Functionally distinct elements are required for expression of the AMPD1 gene in myocytes.

1993 • 24 citations

Quail MyoD Is Regulated by a Complex Array of cis-Acting Control Sequences

1995 • 21 citations

A Single MEF-2 Site Is a Major Positive Regulatory Element Required for Transcription of the Muscle-Specific Subunit of the Human Phosphoglycerate Mutase Gene in Skeletal and Cardiac Muscle Cells

1992 • 16 citations

Promoter Upstream Elements of the Chicken Cardiac Myosin LightChain 2-A Gene Interact with trans-Ading Regulatory Factors for Muscle-Specific Transcription

1989 • 15 citations

Binding of TFIID and MEF2 to the TATA element activates transcription of the Xenopus MyoDa promoter

1994 • 13 citations

Heterodimers of Myogenic Helix-Loop-Helix Regulatory Factors and E12 Bind a Complex Element Governing Myogenic Induction of the Avian Cardiac α-Actin Promoter

1991 • 12 citations

The Basic Helix-Loop-Helix Protein Upstream Stimulating Factor Regulates the Cardiac Ventricular Myosin Light-Chain 2 Gene via Independent cis Regulatory Elements

1994 • 11 citations

Functionally Distinct Elements Are Required for Expression of the AMPD1 Gene in Myocytes

1993 • 2 citations