Heterodimers of myogenic helix-loop-helix regulatory factors and E12 bind a complex element governing myogenic induction of the avian cardiac alpha-actin promoter.

[57] Sequencing end-labeled DNA with base-specific chemical cleavages

1980 • 15,302 citations

Recombinant genomes which express chloramphenicol acetyltransferase in mammalian cells.

1982 • 8,069 citations

Rapid and efficient site-specific mutagenesis without phenotypic selection.

1985 • 7,573 citations

Use of bacteriophage T7 RNA polymerase to direct selective high-level expression of cloned genes

1986 • 6,284 citations

Expression of a single transfected cDNA converts fibroblasts to myoblasts

1987 • 3,373 citations

Recombinant Genomes Which Express Chloramphenicol Acetyltransferase in Mammalian Cells

1982 • 3,106 citations

A new DNA binding and dimerization motif in immunoglobulin enhancer binding, daughterless, MyoD, and myc proteins

1989 • 2,706 citations

The protein Id: A negative regulator of helix-loop-helix DNA binding proteins

1990 • 2,273 citations

Interactions between heterologous helix-loop-helix proteins generate complexes that bind specifically to a common DNA sequence

1989 • 1,876 citations

Transcriptional interference between c-Jun and the glucocorticoid receptor: Mutual inhibition of DNA binding due to direct protein-protein interaction

1990 • 1,583 citations

Transformation of mammalian cells with genes from procaryotes and eucaryotes

1979 • 1,474 citations

Myogenin, a factor regulating myogenesis, has a domain homologous to MyoD

1989 • 1,286 citations

Multiple new phenotypes induced in and 3T3 cells treated with 5-azacytidine

1979 • 1,101 citations

Activation of muscle-specific genes in pigment, nerve, fat, liver, and fibroblast cell lines by forced expression of MyoD.

1989 • 984 citations

Differences and Similarities in DNA-Binding Preferences of MyoD and E2A Protein Complexes Revealed by Binding Site Selection

1990 • 957 citations

A novel human muscle factor related to but distinct from MyoD1 induces myogenic conversion in 10T1/2 fibroblasts.

1989 • 919 citations

Identification of a protein-binding site that mediates transcriptional response of the c-fos gene to serum factors

1986 • 883 citations

Transient accumulation of c-fos RNA following serum stimulation requires a conserved 5′ element and c-fos 3′ sequences

1985 • 871 citations

A gene with homology to the myc similarity region of MyoD1 is expressed during myogenesis and is sufficient to activate the muscle differentiation program.

1989 • 863 citations

MyoD is a sequence-specific DNA binding protein requiring a region of myc homology to bind to the muscle creatine kinase enhancer

1989 • 861 citations

The MyoD DNA binding domain contains a recognition code for muscle-specific gene activation

1990 • 794 citations

Identification of MRF4: a new member of the muscle regulatory factor gene family.

1989 • 779 citations

MyoD family: a paradigm for development?

1990 • 776 citations

Expression of two myogenic regulatory factors myogenin and MyoDl during mouse embryogenesis

1989 • 662 citations

Protein-Binding Sites in Ig Gene Enhancers Determine Transcriptional Activity and Inducibility

1987 • 619 citations

A new myocyte-specific enhancer-binding factor that recognizes a conserved element associated with multiple muscle-specific genes.

1989 • 605 citations

The Complete Amino Acid Sequence of Actins from Bovine Aorta, Bovine Heart, Bovine Fast Skeletal Muscle, and Rabbit, Slow Skeletal Muscle

1979 • 534 citations

Multiple protein-binding sites in the 5'-flanking region regulate c-fos expression.

1986 • 516 citations

Negative Regulation by Glucocorticoids Through Interference with a cAMP Responsive Enhancer

1988 • 502 citations

The achaete-scute gene complex of D. melanogaster: Conserved Domains in a subset of genes required for neurogenesis and their homology to myc

1987 • 501 citations

The ability of a ternary complex to form over the serum response element correlates with serum inducibility of the human c-fos promoter

1989 • 495 citations

Herculin, a fourth member of the MyoD family of myogenic regulatory genes.

1990 • 482 citations

Sequence of the twist gene and nuclear localization of its protein in endomesodermal cells of early Drosophila embryos.

1988 • 471 citations

daughterless, a Drosophila gene essential for both neurogenesis and sex determination, has sequence similarities to myc and the achaete-scute complex

1988 • 442 citations

Upstream regions of the human cardiac actin gene that modulate its transcription in muscle cells: presence of an evolutionarily conserved repeated motif.

1986 • 432 citations

Mutually exclusive interaction of the CCAAT-binding factor and of a displacement protein with overlapping sequences of a histone gene promoter

1987 • 407 citations

Identification and purification of a polypeptide that binds to the c-fos serum response element.

1987 • 398 citations

MyoD expression in the forming somites is an early response to mesoderm induction in Xenopus embryos.

1989 • 374 citations

Differential expression of myogenic determination genes in muscle cells: possible autoactivation by the Myf gene products.

1989 • 349 citations

Muscle-specific expression of the cardiac alpha-actin gene requires MyoD1, CArG-box binding factor, and Sp1.

1990 • 334 citations

Identification of a myocyte nuclear factor that binds to the muscle-specific enhancer of the mouse muscle creatine kinase gene.

1989 • 326 citations

c-fos Sequence Necessary for Basal Expression and Induction by Epidermal Growth Factor, 12-O-Tetradecanoyl Phorbol-13-Acetate and the Calcium Ionophore

1987 • 304 citations

Sequential activation of alpha-actin genes during avian cardiogenesis: vascular smooth muscle alpha-actin gene transcripts mark the onset of cardiomyocyte differentiation.

1988 • 297 citations

MyoD binds cooperatively to two sites in a target enhancer sequence: occupancy of two sites is required for activation.

1990 • 294 citations

Myogenin resides in the nucleus and acquires high affinity for a conserved enhancer element on heterodimerization.

1990 • 278 citations

Closely related transcripts encoded by the neurogenic gene complex enhancer of split of Drosophila melanogaster.

1989 • 274 citations

Sterol-dependent repression of low density lipoprotein receptor promoter mediated by 16-base pair sequence adjacent to binding site for transcription factor Sp1.

1988 • 271 citations

Two adjacent MyoD1-binding sites regulate expression of the acetylcholine receptor α-subunit gene

1990 • 261 citations

Identification of upstream and intragenic regulatory elements that confer cell-type-restricted and differentiation-specific expression on the muscle creatine kinase gene.

1988 • 248 citations

The Drosophila hairy protein acts in both segmentation and bristle patterning and shows homology to N-myc.

1989 • 245 citations

The c-fos serum response element responds to protein kinase C-dependent and -independent signals but not to cyclic AMP.

1988 • 245 citations

Chordate muscle actins differ distinctly from invertebrate muscle actins

1984 • 243 citations

Actin Typing on Total Cellular Extracts

1981 • 234 citations

A yeast operator overlaps an upstream activation site

1987 • 200 citations

Duplicated CArG Box Domains Have Positive and Mutually Dependent Regulatory Roles in Expression of the Human α-Cardiac Actin Gene

1987 • 192 citations

The complete nucleotide sequence of the chick a-actin gene and its evolutionary relationship to the actin gene family

1982 • 183 citations

Casein kinase II enhances the DNA binding activity of serum response factor.

1990 • 181 citations

Xenopus cytoskeletal actin and human c-fos gene promoters share a conserved protein-binding site.

1987 • 181 citations

Muscle-specific expression of the troponin I gene requires interactions between helix-loop-helix muscle regulatory factors and ubiquitous transcription factors.

1991 • 171 citations

Sequential expression of chicken actin genes during myogenesis.

1986 • 169 citations

The sarcomeric actin CArG-binding factor is indistinguishable from the c-fos serum response factor.

1989 • 166 citations

An avian muscle factor related to MyoD1 activates muscle-specific promoters in nonmuscle cells of different germ-layer origin and in BrdU-treated myoblasts.

1989 • 162 citations

Upstream Regions of the Human Cardiac Actin Gene That Modulate Its Transcription in Muscle Cells: Presence of an Evolutionarily Conserved Repeated Motif

1986 • 155 citations

A New Myocyte-Specific Enhancer-Binding Factor That Recognizes a Conserved Element Associated with Multiple Muscle-Specific Genes

1989 • 154 citations

Multiple 5'-flanking regions of the human alpha-skeletal actin gene synergistically modulate muscle-specific expression.

1987 • 150 citations

The CArG promoter sequence is necessary for muscle-specific transcription of the cardiac actin gene in Xenopus embryos.

1989 • 140 citations

Two distinct cellular phosphoproteins bind to the c-fos serum response element.

1989 • 140 citations

Delimitation and characterization of cis-acting DNA sequences required for the regulated expression and transcriptional control of the chicken skeletal alpha-actin gene.

1986 • 137 citations

Cross-Binding of Factors to Functionally Different Promoter Elements in c-fos and Skeletal Actin Genes

1989 • 135 citations

Gene switching in myogenesis: differential expression of the chicken actin multigene family

1981 • 130 citations

A combination of closely associated positive and negative cis-acting promoter elements regulates transcription of the skeletal alpha-actin gene.

1990 • 124 citations

The protein Id: a negative regulator of helix-loop-helix DNA binding proteins

1990 • 123 citations

A common factor regulates skeletal and cardiac alpha-actin gene transcription in muscle.

1988 • 102 citations

Identification of a Myocyte Nuclear Factor That Binds to the Muscle-Specific Enhancer of the Mouse Muscle Creatine Kinase Gene

1989 • 101 citations

Identification of multiple proteins that interact with functional regions of the human cardiac alpha-actin promoter.

1989 • 93 citations

Interaction of Nuclear Proteins with Muscle-Specific Regulatory Sequences of the Human Cardiac α-Actin Promoter

1988 • 93 citations

Muscle-specific (CArG) and serum-responsive (SRE) promoter elements are functionally interchangeable in Xenopus embryos and mouse fibroblasts

1989 • 93 citations

Purification of intercalator-released p67, a polypeptide that interacts specifically with the c-fos serum response element

1987 • 92 citations

Tissue restricted and stage specific transcription is maintained within 411 nucleotides flanking the 5′ end of the chicken α-skeletal actin gene

1986 • 86 citations

Identification of Upstream and Intragenic Regulatory Elements That Confer Cell-Type-Restricted and Differentiation-Specific Expression on the Muscle Creatine Kinase Gene

1988 • 86 citations

Structure and complete nucleotide sequence of the chicken alpha-smooth muscle (aortic) actin gene. An actin gene which produces multiple messenger RNAs.

1986 • 79 citations

Two Distinct Xenopus Genes with Homology to MyoD1 Are Expressed before Somite Formation in Early Embryogenesis

1990 • 75 citations

The complete sequence of the chicken α-cardiac actin gene: a highly conserved vertebrate gene

1985 • 73 citations

Isolation and characterization of six different chicken actin genes.

1984 • 68 citations

Cross-binding of factors to functionally different promoter elements in c-fos and skeletal actin genes.

1989 • 64 citations

DNA-binding site for two skeletal actin promoter factors is important for expression in muscle cells.

1988 • 58 citations

Hierarchies of regulatory genes may specify mammalian development

1988 • 50 citations

Muscle-Specific Expression of the Troponin I Gene Requires Interactions between Helix-Loop-Helix Muscle Regulatory Factors and Ubiquitous Transcription Factors

1991 • 48 citations

Multiple 5′-Flanking Regions of the Human α-Skeletal Actin Gene Synergistically Modulate Muscle-Specific Expression

1987 • 42 citations

Cellular localization of muscle and nonmuscle actin mRNAs in chicken primary myogenic cultures: the induction of alpha-skeletal actin mRNA is regulated independently of alpha-cardiac actin gene expression.

1988 • 40 citations

The chicken skeletal alpha-actin gene promoter region exhibits partial dyad symmetry and a capacity to drive bidirectional transcription.

1988 • 37 citations

Identification of Multiple Proteins That Interact with Functional Regions of the Human Cardiac α-Actin Promoter

1989 • 34 citations

A Common Factor Regulates Skeletal and Cardiac α-Actin Gene Transcription in Muscle

1988 • 31 citations

Identification of Two Nuclear Factor-Binding Domains on the Chicken Cardiac Actin Promoter: Implications for Regulation of the Gene

1989 • 31 citations

MyoD expression in the forming somites is an early response to mesoderm induction in Xenopus embryos

1989 • 21 citations

DNA-Binding Site for Two Skeletal Actin Promoter Factors Is Important for Expression in Muscle Cells

1988 • 21 citations

Isolation and Characterization of Six Different Chicken Actin Genes

1984 • 21 citations

The Chicken Skeletal α-Actin Gene Promoter Region Exhibits Partial Dyad Symmetry and a Capacity To Drive Bidirectional Transcription

1988 • 14 citations

Identification of two nuclear factor-binding domains on the chicken cardiac actin promoter: implications for regulation of the gene.

1989 • 9 citations