A Bcl-2-dependent molecular timer regulates the lifespan and immunogenicity of dendritic cells

Dendritic cells and the control of immunity

1998 • 14,345 citations

A Toll-like receptor recognizes bacterial DNA

2000 • 6,348 citations

Toll-Like Receptors

2003 • 6,127 citations

Generation of large numbers of dendritic cells from mouse bone marrow cultures supplemented with granulocyte/macrophage colony-stimulating factor.

1992 • 3,751 citations

Tolerogenic Dendritic Cells

2003 • 3,131 citations

RAG-1-deficient mice have no mature B and T lymphocytes

1992 • 2,859 citations

Chromatin–IgG complexes activate B cells by dual engagement of IgM and Toll-like receptors

2002 • 1,877 citations

In Vivo Depletion of CD11c+ Dendritic Cells Abrogates Priming of CD8+ T Cells by Exogenous Cell-Associated Antigens

2002 • 1,734 citations

Peptidoglycan- and Lipoteichoic Acid-induced Cell Activation Is Mediated by Toll-like Receptor 2

1999 • 1,714 citations

Bcl-2-deficient mice demonstrate fulminant lymphoid apoptosis, polycystic kidneys, and hypopigmented hair

1993 • 1,638 citations

CD40 AND CD154 IN CELL-MEDIATED IMMUNITY

1998 • 1,546 citations

Proapoptotic Bcl-2 Relative Bim Required for Certain Apoptotic Responses, Leukocyte Homeostasis, and to Preclude Autoimmunity

1999 • 1,500 citations

Defective TCR expression in transgenic mice constructed using cDNA‐based α‐ and β‐chain genes under the control of heterologous regulatory elements

1998 • 1,460 citations

Activation of human dendritic cells through CD40 cross-linking.

1994 • 1,351 citations

Massive Cell Death of Immature Hematopoietic Cells and Neurons in Bcl-x-Deficient Mice

1995 • 1,167 citations

TRANCE (Tumor Necrosis Factor [TNF]-related Activation-induced Cytokine), a New TNF Family Member Predominantly Expressed in T cells, Is a Dendritic Cell–specific Survival Factor

1997 • 869 citations

CpG DNA as a vaccine adjuvant

2011 • 828 citations

Dendritic Cell Survival and Maturation Are Regulated by Different Signaling Pathways

1998 • 685 citations

Inherited Human Caspase 10 Mutations Underlie Defective Lymphocyte and Dendritic Cell Apoptosis in Autoimmune Lymphoproliferative Syndrome Type II

1999 • 631 citations

In Vivo Detection of Dendritic Cell Antigen Presentation to CD4+ T Cells

1997 • 560 citations

Recognition of microbial infection by Toll-like receptors

2003 • 556 citations

RETRACTED: Uncoupling IL-2 Signals that Regulate T Cell Proliferation, Survival, and Fas-Mediated Activation-Induced Cell Death

1999 • 443 citations

The PI3 kinase, p38 SAP kinase, and NF-κB signal transduction pathways are involved in the survival and maturation of lipopolysaccharide-stimulated human monocyte–derived dendritic cells

2000 • 440 citations

Dendritic Cell Development and Survival Require Distinct NF-κB Subunits

2002 • 395 citations

Trance, a Tumor Necrosis Factor Family Member, Enhances the Longevity and Adjuvant Properties of Dendritic Cells in Vivo

2000 • 335 citations

Degenerative Disorders Caused by Bcl-2 Deficiency Prevented by Loss of Its BH3-Only Antagonist Bim

2001 • 270 citations

Inactivation of bcl-2 Results in Progressive Degeneration of Motoneurons, Sympathetic and Sensory Neurons during Early Postnatal Development

1996 • 263 citations

Recombinant adenovirus is an efficient and non-perturbing genetic vector for human dendritic cells

1999 • 226 citations

Conditional deletion of the Bcl-x gene from erythroid cells results in hemolytic anemia and profound splenomegaly

2000 • 201 citations

Endogenous Dendritic Cells Are Required for Amplification of T Cell Responses Induced by Dendritic Cell Vaccines In Vivo

2003 • 151 citations

Dendritic cell longevity and T cell persistence is controlled by CD154-CD40 interactions

2001 • 135 citations

Antigen-specific T lymphocytes regulate lipopolysaccharide-induced apoptosis of dendritic cells in vivo.

1998 • 133 citations

Bcl-2 Controls Dendritic Cell Longevity In Vivo

2002 • 123 citations

IL-2 and Related Cytokines Can Promote T Cell Survival by Activating AKT

2002 • 111 citations

Cutting Edge: Antigen-Specific T Lymphocytes Regulate Lipopolysaccharide-Induced Apoptosis of Dendritic Cells In Vivo

1998 • 110 citations

Cutting Edge: CpG DNA Inhibits Dendritic Cell Apoptosis by Up-Regulating Cellular Inhibitor of Apoptosis Proteins Through the Phosphatidylinositide-3′-OH Kinase Pathway

2002 • 104 citations

CpG DNA as a vaccine adjuvant

2003 • 97 citations

The use of carboxyfluorescein diacetate succinimidyl ester to determine the site, duration and cell type responsible for antigen presentation in vivo

1999 • 37 citations