Identification of Critical Residues Controlling G Protein-gated Inwardly Rectifying K+ Channel Activity through Interactions with the βγ Subunits of G Proteins

Improved patch-clamp techniques for high-resolution current recording from cells and cell-free membrane patches

1981 • 18,584 citations

The Structure of the Potassium Channel: Molecular Basis of K ⁺ Conduction and Selectivity

1998 • 6,595 citations

Engineering hybrid genes without the use of restriction enzymes: gene splicing by overlap extension

1989 • 3,067 citations

The βγ subunits of GTP-binding proteins activate the muscarinic K+ channel in heart

1987 • 1,186 citations

Subunit stoichiometry of a mammalian K+ channel determined by construction of multimeric cDNAs

1992 • 1,067 citations

Direct activation of inward rectifier potassium channels by PIP2 and its stabilization by Gβγ

1998 • 886 citations

GTP-binding proteins couple cardiac muscarinic receptors to a K channel

1985 • 868 citations

The G-protein-gated atrial K+ channel IKAch is a heteromultimer of two inwardly rectifying K+-channel proteins

1995 • 830 citations

Primary structure and functional expression of a rat G-protein-coupled muscarinic potassium channel

1993 • 600 citations

Uncoupling of cardiac muscarinic and β-adrenergic receptors from ion channels by a guanine nucleotide analogue

1985 • 527 citations

Activation of the cloned muscarinic potassium channel by G protein βγ subunits

1994 • 472 citations

G protein regulation of potassium ion channels.

1998 • 379 citations

Atrial G protein-activated K+ channel: expression cloning and molecular properties.

1993 • 355 citations

Activation of inwardly rectifying K+ channels by distinct PtdIns(4,5)P2 interactions

1999 • 346 citations

Purification of Recombinant G Proteins from Sf9 Cells by Hexahistidine Tagging of Associated Subunits

1995 • 332 citations

Evidence that direct binding of Gβγ to the GIRK1 G protein-gated inwardly rectifying K+ channel is important for channel activation

1995 • 324 citations

Crystal Structure at 2.4 Å Resolution of the Complex of Transducin βγ and Its Regulator, Phosducin

1996 • 289 citations

Cloning provides evidence for a family of inward rectifier and G‐protein coupled K⁺ channels in the brain

1994 • 280 citations

Zum Mechanismus der Membranwirkung des Acetylcholin an der Herzmuskelfaser

1958 • 247 citations

Activation of the atrial K _ACh channel by the βγ subunits of G proteins or intracellular Na ⁺ ions depends on the presence of phosphatidylinositol phosphates

1998 • 244 citations

Gβγ Binds Directly to the G Protein-gated K+ Channel, IKACh

1995 • 227 citations

Probing the G-protein Regulation of GIRK1 and GIRK4, the Two Subunits of the KACh Channel, Using Functional Homomeric Mutants

1997 • 154 citations

Identification of domains conferring G protein regulation on inward rectifier potassium channels

1995 • 146 citations

Voltage clamping of Xenopus laevis oocytes utilizing agarose-cushion electrodes

1994 • 145 citations

Binding of the G protein βγ subunit to multiple regions of G protein‐gated inward‐rectifying K⁺ channels

1997 • 128 citations

Na+ activation of the muscarinic K+ channel by a G-protein-independent mechanism.

1996 • 125 citations

Control of channel activity through a unique amino acid residue of a G protein-gated inwardly rectifying K ⁺ channel subunit

1996 • 111 citations

Identification of a Potassium Channel Site That Interacts with G Protein βγ Subunits to Mediate Agonist-induced Signaling

1999 • 111 citations

Molecular mechanism for sodium‐dependent activation of G protein‐gated K⁺ channels

1999 • 101 citations

Gβγ Directly Binds to the Carboxyl Terminus of the G Protein-Gated Muscarinic K+ Channel, GIRK1

1995 • 95 citations

Gβγ Binding to GIRK4 Subunit Is Critical for G Protein-gated K+ Channel Activation

1998 • 84 citations

A recombinant inwardly rectifying potassium channel coupled to GTP-binding proteins.

1996 • 71 citations

A Domain on the G Protein β Subunit Interacts with Both Adenylyl Cyclase 2 and the Muscarinic Atrial Potassium Channel

1996 • 69 citations

Inhibition of an Inward Rectifier Potassium Channel (Kir2.3) by G-protein βγ Subunits

1996 • 58 citations

Specific Regions of Heteromeric Subunits Involved in Enhancement of G Protein-gated K+ Channel Activity

1997 • 54 citations

Methods in pharmacology and toxicology

2002 • 39 citations

8 G protein gated potassium channels

1999 • 25 citations

Identification of Domains of the Cardiac Inward Rectifying K+Channel, CIR, Involved in the Heteromultimer Formation and in the G-Protein Gating

1996 • 23 citations

Localization and Quantification of GFP-Tagged Ion Channels Expressed in Xenopus Oocytes

2003 • 7 citations