The mGlu2 but not the mGlu3 receptor mediates the actions of the mGluR2/3 agonist, LY379268, in mouse models predictive of antipsychotic activity

A sharper Bonferroni procedure for multiple tests of significance

1988 • 4,545 citations

PHARMACOLOGY AND FUNCTIONS OF METABOTROPIC GLUTAMATE RECEPTORS

1997 • 3,070 citations

Schizophrenia genes, gene expression, and neuropathology: on the matter of their convergence

2004 • 2,021 citations

Functional Selectivity and Classical Concepts of Quantitative Pharmacology

2006 • 1,076 citations

Activation of mGlu2/3 receptors as a new approach to treat schizophrenia: a randomized Phase 2 clinical trial

2007 • 1,021 citations

Reversal of Phencyclidine Effects by a Group II Metabotropic Glutamate Receptor Agonist in Rats

1998 • 1,002 citations

Regulation of Neurotransmitter Release by Metabotropic Glutamate Receptors

2000 • 880 citations

Metabotropic glutamate receptors: electrophysiological properties and role in plasticity

1999 • 770 citations

Variation in GRM3 affects cognition, prefrontal glutamate, and risk for schizophrenia

2004 • 410 citations

Impairment of Hippocampal Mossy Fiber LTD in Mice Lacking mGluR2

1996 • 342 citations

Distribution of metabotropic glutamate receptor mGluR3 in the mouse CNS: differential location relative to pre- and postsynaptic sites

2001 • 338 citations

Preliminary evidence of attenuation of the disruptive effects of the NMDA glutamate receptor antagonist, ketamine, on working memory by pretreatment with the group II metabotropic glutamate receptor agonist, LY354740, in healthy human subjects

2004 • 267 citations

The metabotropic glutamate 2/3 receptor agonists LY354740 and LY379268 selectively attenuate phencyclidine versus d-amphetamine motor behaviors in rats.

1999 • 266 citations

A Selective Allosteric Potentiator of Metabotropic Glutamate (mGlu) 2 Receptors Has Effects Similar to an Orthosteric mGlu2/3 Receptor Agonist in Mouse Models Predictive of Antipsychotic Activity

2005 • 170 citations

Biphenyl-indanone A, a Positive Allosteric Modulator of the Metabotropic Glutamate Receptor Subtype 2, Has Antipsychotic- and Anxiolytic-Like Effects in Mice

2006 • 168 citations

Metabotropic glutamate 2 receptor potentiators: receptor modulation, frequency-dependent synaptic activity, and efficacy in preclinical anxiety and psychosis model(s)

2005 • 155 citations

Positive associations of polymorphisms in the metabotropic glutamate receptor type 3 gene ( GRM3 ) with schizophrenia

2003 • 127 citations

Preclinical Pharmacology of mGlu2 / 3 Receptor Agonists: Novel Agents for Schizophrenia?

2002 • 102 citations

Lack of effect of LY314582 (a group 2 metabotropic glutamate receptor agonist) on phencyclidine-induced locomotor activity in metabotropic glutamate receptor 2 knockout mice

2000 • 94 citations

Group II mGlu Receptor Activation Suppresses Norepinephrine Release in the Ventral Hippocampus and Locomotor Responses to Acute Ketamine Challenge

2003 • 92 citations

The mGlu2/3 receptor agonist LY379268 selectively blocks amphetamine ambulations and rearing

2000 • 91 citations

Metabotropic glutamate receptor 3 (GRM3) gene variation is not associated with schizophrenia or bipolar affective disorder in the German population

2001 • 90 citations

A case-control study of the relationship between the metabotropic glutamate receptor 3 gene and schizophrenia in the Chinese population

2004 • 83 citations

LABORAS™: Initial pharmacological validation of a system allowing continuous monitoring of laboratory rodent behaviour

2003 • 78 citations

Characterization of Milk Cortisol Concentrations as a Measure of Short-Term Stress Responses in Lactating Dairy Cows

1998 • 70 citations

Effects of the mGluR2/3 agonist LY379268 on ketamine-evoked behaviours and neurochemical changes in the dentate gyrus of the rat

2006 • 63 citations

Phenyl-tetrazolyl Acetophenones: Discovery of Positive Allosteric Potentiatiors for the Metabotropic Glutamate 2 Receptor

2004 • 58 citations

Alternative splicing of human metabotropic glutamate receptor 3

2006 • 58 citations

Reversal of a dizocilpine-induced disruption of prepulse inhibition of an acoustic startle response by the 5-HT2 receptor antagonist ketanserin

1995 • 56 citations

Allosteric potentiators of the metabotropic glutamate receptor 2 (mGlu2). Part 3: Identification and biological activity of indanone containing mGlu2 receptor potentiators

2005 • 50 citations

Structure and polymorphisms of the human metabotropic glutamate receptor type 2 gene (GRM2): analysis of association with schizophrenia

2001 • 49 citations

Habituation Deficits Induced by Metabotropic Glutamate Receptors 2/3 Receptor Blockade in Mice: Reversal by Antipsychotic Drugs

2006 • 47 citations

Effects of mGlu2 or mGlu3 receptor deletions on mGlu2/3 receptor agonist (LY354740)-induced brain c-Fos expression: Specific roles for mGlu2 in the amygdala and subcortical nuclei, and mGlu3 in the hippocampus

2006 • 45 citations

Benzazoles as allosteric potentiators of metabotropic glutamate receptor 2 (mGluR2): Efficacy in an animal model for schizophrenia

2005 • 43 citations

A Balance Device for the Analysis of Behavioural Patterns of the Mouse

1998 • 19 citations