The C-Terminus of the Prostaglandin-E-Receptor EP3 Subtype is Essential for Activation of GTP-Binding Protein

DNA sequencing with chain-terminating inhibitors

1977 • 69,181 citations

A Simplex Method for Function Minimization

1965 • 27,535 citations

G PROTEINS: TRANSDUCERS OF RECEPTOR-GENERATED SIGNALS

1987 • 6,374 citations

Lipofection: a highly efficient, lipid-mediated DNA-transfection procedure.

1987 • 4,937 citations

A pharmacokinetic analysis program (multi) for microcomputer.

1981 • 2,465 citations

A ternary complex model explains the agonist-specific binding properties of the adenylate cyclase-coupled beta-adrenergic receptor.

1980 • 1,579 citations

A mutation-induced activated state of the beta 2-adrenergic receptor. Extending the ternary complex model.

1993 • 1,213 citations

Receptor-effector coupling by G proteins

1990 • 1,117 citations

Chimeric α ₂ -,β ₂ -Adrenergic Receptors: Delineation of Domains Involved in Effector Coupling and Ligand Binding Specificity

1988 • 766 citations

Regulation of transmembrane signaling by receptor phosphorylation

1987 • 678 citations

Site-directed mutagenesis of the cytoplasmic domains of the human beta 2-adrenergic receptor. Localization of regions involved in G protein-receptor coupling.

1988 • 400 citations

Rhodopsin Mutants That Bind But Fail to Activate Transducin

1990 • 377 citations

Three cytoplasmic loops of rhodopsin interact with transducin.

1989 • 370 citations

Regions of the alpha 1-adrenergic receptor involved in coupling to phosphatidylinositol hydrolysis and enhanced sensitivity of biological function.

1990 • 302 citations

Identification of a Gs activator region of the β2-adrenergic receptor that is autoregulated via protein kinase A-dependent phosphorylation

1991 • 273 citations

Direct linkage of three tachykinin receptors to stimulation of both phosphatidylinositol hydrolysis and cyclic AMP cascades in transfected Chinese hamster ovary cells.

1992 • 259 citations

Mutations that uncouple the beta-adrenergic receptor from Gs and increase agonist affinity.

1987 • 259 citations

A general method for introducing a series of mutations into cloned DNA using the polymerase chain reaction

1991 • 253 citations

Cell adhesion activity of non-specific cross-reacting antigen (NCA) and carcinoembryonic antigen (CEA) expressed on CHO cell surface: Homophilic and heterophilic adhesion

1989 • 236 citations

Two isoforms of the EP3 receptor with different carboxyl-terminal domains. Identical ligand binding properties and different coupling properties with Gi proteins.

1993 • 214 citations

Third isoform of the prostaglandin‐E‐receptor EP₃ subtype with different C‐terminal tail coupling to both stimulation and inhibition of adenylate cyclase

1993 • 175 citations

Location of a region of the muscarinic acetylcholine receptor involved in selective effector coupling

1988 • 167 citations

Cell-specific physical and functional coupling of human 5-HT1A receptors to inhibitory G protein .alpha.-subunits and lack of coupling to Gs.alpha.

1993 • 145 citations

Structure-Function Analysis of the -Adrenergic Receptor

1988 • 145 citations

A mutation of the beta 2-adrenergic receptor impairs agonist activation of adenylyl cyclase without affecting high affinity agonist binding. Distinct molecular determinants of the receptor are involved in physical coupling to and functional activation of Gs.

1990 • 130 citations

Effects of truncations of the cytoplasmic tail of the luteinizing hormone/chorionic gonadotropin receptor on receptor-mediated hormone internalization.

1992 • 98 citations

Amino acids 356–372 constitute a G_i‐activator sequence of the α₂‐adrenergic receptor and have a Phe substitute in the G protein‐activator sequence motif

1992 • 66 citations

Major pertussis‐toxin‐sensitive GTP‐binding protein of bovine lung

1988 • 43 citations

Functional interaction of prostaglandin E receptor EP3 subtype with guanine nucleotide-binding proteins, showing low-affinity ligand binding

1993 • 34 citations

Effects of truncations of the cytoplasmic tail of the luteinizing hormone/chorionic gonadotropin receptor on receptor-mediated hormone internalization

1992 • 29 citations