Two thromboxane A2 receptor isoforms in human platelets. Opposite coupling to adenylyl cyclase with different sensitivity to Arg60 to Leu mutation.

Single-Step Method of RNA Isolation by Acid Guanidinium Thiocyanate–Phenol–Chloroform Extraction

1987 • 64,270 citations

A new technique for the assay of infectivity of human adenovirus 5 DNA

1973 • 9,740 citations

Changes in the levels of inositol phosphates after agonist-dependent hydrolysis of membrane phosphoinositides

1983 • 1,937 citations

cPLA2 is phosphorylated and activated by MAP kinase

1993 • 1,858 citations

Direct repeats as selective response elements for the thyroid hormone, retinoic acid, and vitamin D3 receptors

1991 • 1,725 citations

pEF-BOS, a powerful mammalian expression vector

1990 • 1,641 citations

Chromosomal translocation t(15;17) in human acute promyelocytic leukemia fuses RARα with a novel putative transcription factor, PML

1991 • 1,463 citations

Prostaglandins and Thromboxanes

1978 • 1,310 citations

Molecular cloning and functional expression of two monocyte chemoattractant protein 1 receptors reveals alternative splicing of the carboxyl-terminal tails.

1994 • 711 citations

Alternative splicing directs the expression of two D2 dopamine receptor isoforms

1989 • 692 citations

Cloning and expression of cDNA for a human thromboxane A2 receptor

1991 • 680 citations

Multiple D2 dopamine receptors produced by alternative RNA splicing

1989 • 642 citations

The dopamine D2 receptor: two molecular forms generated by alternative splicing.

1989 • 596 citations

Alternative splicing of C-terminal tail of prostaglandin E receptor subtype EP3 determines G-protein specificity

1993 • 546 citations

Molecular characterization of a functional cDNA for rat substance P receptor

1989 • 463 citations

The G protein coupled to the thromboxane A2 receptor in human platelets is a member of the novel Gq family

1991 • 373 citations

Biochemical mechanisms of platelet activation

1989 • 370 citations

Alternative splicing produces a divergent cytoplasmic tail in the human endothelial thromboxane A2 receptor.

1994 • 357 citations

Biochemical mechanisms of platelet activation

1989 • 328 citations

Thromboxane, Prostaglandin and Leukotriene Receptors

1989 • 258 citations

Differential activation of intracellular effector by two isoforms of human neurokinin-1 receptor.

1992 • 242 citations

Blot hybridisation analysis of genomic DNA.

1984 • 224 citations

Two isoforms of the EP3 receptor with different carboxyl-terminal domains. Identical ligand binding properties and different coupling properties with Gi proteins.

1993 • 214 citations

Arg60 to Leu mutation of the human thromboxane A2 receptor in a dominantly inherited bleeding disorder.

1994 • 188 citations

Inositol 1,4,5-triphosphate-induced granule secretion in platelets. Evidence that the activation of phospholipase C mediated by platelet thromboxane receptors involves a guanine nucleotide binding protein-dependent mechanism distinct from that of thrombin.

1987 • 156 citations

Purification of the thromboxane A2/prostaglandin H2 receptor from human blood platelets

1989 • 154 citations

The response to thromboxane A2 analogues in human platelets. Discrimination of two binding sites linked to distinct effector systems.

1990 • 141 citations

Characterization and chromosomal mapping of the human thromboxane A2 receptor gene.

1993 • 140 citations

Two isoforms of prostaglandin E receptor EP3 subtype. Different COOH-terminal domains determine sensitivity to agonist-induced desensitization

1993 • 134 citations

Thromboxane A2/prostaglandin H2-stimulated mitogenesis of coronary artery smooth muscle cells involves activation of mitogen-activated protein kinase and S6 kinase.

1994 • 108 citations

Characterization of [5,6-3H]SQ 29,548 as a high affinity radioligand, binding to thromboxane A2/prostaglandin H2-receptors in human platelets.

1988 • 87 citations

Characterization of a new compound, S-145, as a specific TXA2 receptor antagonist in platelets

1988 • 73 citations

Distinct platelet thromboxane A2/prostaglandin H2 receptor subtypes. A radioligand binding study of human platelets.

1989 • 67 citations

Functional reconstitution of platelet thromboxane A2 receptors with Gq and Gi2 in phospholipid vesicles.

1994 • 60 citations

Prostaglandins and Thromboxanes

1978 • 59 citations

Defective signal transduction induced by thromboxane A2 in a patient with a mild bleeding disorder: impaired phospholipase C activation despite normal phospholipase A2 activation

1993 • 43 citations

Hemorrhagic Thrombocytopathy with Platelet Thromboxane A2 Receptor Abnormality: Defective Signal Transduction with Normal Binding Activity

1987 • 41 citations

Receptor-mediated effects of a PGH2 analogue (U 46619) on human platelets

1987 • 36 citations

Dihydropyridine agonist Bay K 8644 inhibits platelet activation by competitive antagonism of thromboxane A2-prostaglandin H2 receptor.

1988 • 34 citations

Signal Transduction in Collagen-Stimulated Rat Platelets Is Composed of Three Stages

1987 • 30 citations

Human platelet aggregation and shape change are coupled to separate thromboxane A2-prostaglandin H2 receptors

1991 • 29 citations

Thromboxane, Prostaglandin And Leukotriene Receptors

1989 • 8 citations

Elevation of platelet cyclic AMP level by thromboxane A2/prostaglandin H2 receptor agonists

1991 • 3 citations

Arg[60] to Leu mutation of the human thromboxane A[2] receptor in a dominantly inherited bleeding disorder

1995 • 3 citations