Arg60 to Leu mutation of the human thromboxane A2 receptor in a dominantly inherited bleeding disorder.

Single-Step Method of RNA Isolation by Acid Guanidinium Thiocyanate–Phenol–Chloroform Extraction

1987 • 64,270 citations

A new technique for the assay of infectivity of human adenovirus 5 DNA

1973 • 9,740 citations

Aggregation of Blood Platelets by Adenosine Diphosphate and its Reversal

1962 • 4,273 citations

Changes in the levels of inositol phosphates after agonist-dependent hydrolysis of membrane phosphoinositides

1983 • 1,937 citations

pEF-BOS, a powerful mammalian expression vector

1990 • 1,641 citations

Chromosomal translocation t(15;17) in human acute promyelocytic leukemia fuses RARα with a novel putative transcription factor, PML

1991 • 1,463 citations

Cloning and expression of the human and rat m5 muscarinic acetylcholine receptor genes

1988 • 792 citations

A constitutively activating mutation of the luteinizing hormone receptor in familial male precocious puberty

1993 • 747 citations

Cloning and expression of cDNA for a human thromboxane A2 receptor

1991 • 680 citations

Cloning of the cDNA for the human beta 1-adrenergic receptor.

1987 • 577 citations

Constitutively active mutants of rhodopsin

1992 • 513 citations

Molecular characterization of a functional cDNA for rat substance P receptor

1989 • 463 citations

Site-directed mutagenesis of the cytoplasmic domains of the human beta 2-adrenergic receptor. Localization of regions involved in G protein-receptor coupling.

1988 • 400 citations

The G protein coupled to the thromboxane A2 receptor in human platelets is a member of the novel Gq family

1991 • 373 citations

Molecular identification of the gene responsible for congenital nephrogenic diabetes insipidus

1992 • 331 citations

Coexpression studies with mutant muscarinic/adrenergic receptors provide evidence for intermolecular "cross-talk" between G-protein-linked receptors.

1993 • 321 citations

Cloning, sequencing and expression of human TSH receptor

1990 • 297 citations

Expansion of the alpha 2-adrenergic receptor family: cloning and characterization of a human alpha 2-adrenergic receptor subtype, the gene for which is located on chromosome 2.

1990 • 287 citations

Differential activation of intracellular effector by two isoforms of human neurokinin-1 receptor.

1992 • 242 citations

Blot hybridisation analysis of genomic DNA.

1984 • 224 citations

Nephrogenic diabetes insipidus. A V2 vasopressin receptor unable to stimulate adenylyl cyclase

1993 • 185 citations

Inositol 1,4,5-triphosphate-induced granule secretion in platelets. Evidence that the activation of phospholipase C mediated by platelet thromboxane receptors involves a guanine nucleotide binding protein-dependent mechanism distinct from that of thrombin.

1987 • 156 citations

Purification of the thromboxane A2/prostaglandin H2 receptor from human blood platelets

1989 • 154 citations

Characterization of mutant rhodopsins responsible for autosomal dominant retinitis pigmentosa. Mutations on the cytoplasmic surface affect transducin activation

1993 • 142 citations

Characterization and chromosomal mapping of the human thromboxane A2 receptor gene.

1993 • 140 citations

Platelet activating factor and U44069 stimulate a GTPase activity in human platelets which is distinct from the guanine nucleotide regulatory proteins, Ns and Ni

1986 • 132 citations

Abnormalities in G protein-coupled signal transduction pathways in human disease.

1993 • 118 citations

Competitive antagonism at thromboxane receptors in human platelets

1985 • 83 citations

Mutations in G protein-linked receptors: Novel insights on disease

1993 • 73 citations

Evidence of paired M2 muscarinic receptors.

1991 • 72 citations

Impaired platelet response to thromboxane-A2 and defective calcium mobilization in a patient with a bleeding disorder

1981 • 54 citations

Abnormal platelet response to thromboxane A2.

1981 • 50 citations

Defective signal transduction induced by thromboxane A2 in a patient with a mild bleeding disorder: impaired phospholipase C activation despite normal phospholipase A2 activation

1993 • 43 citations

Hemorrhagic Thrombocytopathy with Platelet Thromboxane A2 Receptor Abnormality: Defective Signal Transduction with Normal Binding Activity

1987 • 41 citations

Two affinity states of M1 muscarine receptors

1988 • 40 citations

A new congenital defect of platelet secretion: impaired responsiveness of the platelets to cytoplasmic free calcium

1983 • 37 citations

Constitutional Thrombocytopathy with Subnormal Response to Thromboxane A₂

1981 • 34 citations

Subnormal platelet response to thromboxane A₂ in a patient with chronic myeloid leukaemia

1982 • 26 citations

Analysis of the Defective Signal Transduction Mechanism through the Platelet Thromboxane A2 Receptor in a Patient with Polycythemia Vera

1992 • 20 citations

Hereditary Bleeding Disorder due to a Primary Defect in Platelet Release Reaction

1981 • 20 citations

A new familial defect of platelet release mechanism (the intracellular Ca++ transport defect?).

1981 • 18 citations

Defective platelet aggregation to the calcium ionophore A23187 in a patient with a lifelong bleeding disorder.

1983 • 16 citations

Defective signal transduction induced by thromboxane A2 in a patient with a mild bleeding disorder: impaired phospholipase C activation despite normal phospholipase A2 activation

1993 • 4 citations

Impaired platelet response to thromboxane-A2 and defective calcium mobilization in a patient with a bleeding disorder

1981 • 4 citations