Interpreting MHC class I expression and class I/class II reciprocity in the CNS: Reconciling divergent findings

Perivascular Microglial Cells of the CNS Are Bone Marrow-Derived and Present Antigen in Vivo

1988 • 1,451 citations

Two populations of Ia-like molecules on a human B cell line.

1980 • 1,112 citations

Inducible expression of H–2 and Ia antigens on brain cells

1984 • 656 citations

Expression of the histocompatibility glycoprotein HLA-DR in neurological disease

1988 • 397 citations

Presentation of Exogenous Antigen with Class I Major Histocompatibility Complex Molecules

1990 • 338 citations

Peptide binding to class I MHC on living cells and quantitation of complexes required for CTL lysis

1991 • 336 citations

The costimulatory function of antigen-presenting cells

1990 • 304 citations

Class II MHC molecules can use the endogenous pathway of antigen presentation

1990 • 271 citations

Striking paucity of HLA-A, B, C and beta 2-microglobulin on human neuroblastoma cell lines.

1983 • 257 citations

Presence of T-cytotoxic suppressor and leucocyte common antigen positive cells in Alzheimer's disease brain tissue

1988 • 248 citations

Intrathecal application of interferon gamma. Progressive appearance of MHC antigens within the rat nervous system.

1990 • 240 citations

The binary logic of antigen processing and presentation to T cells

1990 • 235 citations

Monoclonal antibody analysis of MHC expression in human brain biopsies: tissue ranging from "histologically normal" to that showing different levels of glial tumor involvement.

1986 • 230 citations

The distribution of Ia antigen in the lesions of rat acute experimental allergic encephalomyelitis

1986 • 214 citations

Ia-restricted encephalitogenic T lymphocytes mediating EAE lyse autoantigen-presenting astrocytes

1986 • 214 citations

Measles virus-specific T4+ human cytotoxic T cell clones are restricted by class II HLA antigens.

1984 • 209 citations

Detection of HLA-DR on microglia in the human brain is a function of both clinical and technical factors.

1990 • 207 citations

Suppression of experimental allergic encephalomyelitis by intraventricular administration of interferon-gamma in Lewis rats

1990 • 207 citations

Dissection of an inflammatory process induced by CD8+ T cells

1990 • 187 citations

Coronavirus Infection Induces H-2 Antigen Expression on Oligodendrocytes and Astrocytes

1986 • 172 citations

Multiple sclerosis: relevance of Class I and Class II MHC-expressing cells to lesion development

1987 • 169 citations

Major histocompatibility complex antigen expression on rat microglia following epidural kainic acid lesions

1988 • 162 citations

Molecular bases of the immune response to neural antigens

1987 • 156 citations

Multiple Sclerosis: A Role for Astroglia in Active Demyelination Suggested by Class II MHC Expression and Ultrastructural Study

1990 • 145 citations

Immunohistochemical characterization of the inflammatory infiltrate in amyotrophic lateral sclerosis

1990 • 142 citations

Norepinephrine inhibits gamma-interferon-induced major histocompatibility class II (Ia) antigen expression on cultured astrocytes via beta-2-adrenergic signal transduction mechanisms.

1988 • 142 citations

Immune modulation within the brain: recruitment of inflammatory cells and increased major histocompatibility antigen expression following intracerebral injection of interferon-γ

1991 • 136 citations

Major histocompatibility complex antigen expression in the affected tissues in amyotrophic lateral sclerosis

1990 • 125 citations

Immunology of the Nervous System

1998 • 121 citations

Antiphospholipid antibodies: more than just a disease marker?

1990 • 121 citations

Dysmyelination in transgenic mice resulting from expression of class I histocompatibility molecules in oligodendrocytes

1991 • 116 citations

Discrepancy between in vitro measurable and in vivo virus neutralizing cytotoxic T cell reactivities. Low T cell receptor specificity and avidity sufficient for in vitro proliferation or cytotoxicity to peptide-coated target cells but not for in vivo protection.

1992 • 107 citations

Weak HLA and beta 2-microglobulin expression of neuronal cell lines can be modulated by interferon.

1984 • 105 citations

On the immunopathology of plaque development and repair in multiple sclerosis

1988 • 102 citations

Rat ependyma and microglia cells express class II MHC antigens after intravenous infusion of recombinant gamma interferon

1988 • 101 citations

Cell type‐specific regulation of major histocompatibility complex (MHC) Class I gene expression in astrocytes, oligodendrocytes, and neurons

1993 • 94 citations

Immunohistochemical studies of adult human glial cells

1989 • 89 citations

Local enhancement of major histocompatibility complex (MHC) class I and II expression and cell infiltration in experimental allergic encephalomyelitis around axotomized motor neurons

1989 • 88 citations

Interferon-β specifically inhibits interferon-γ-induced class II major histocompatibility complex gene transcription in a human astrocytoma cell line

1991 • 86 citations

In situ detection of class I and II major histocompatibility complex antigens in the rat central nervous system during experimental allergic encephalomyelitis

1986 • 86 citations

Cerebrospinal fluid ß ₂ microglobulin in patients infected with human immunodeficiency virus

1989 • 80 citations

Astrocyte Expression of Major Histocompatibility Complex Gene Products in Multiple Sclerosis Brain Tissue Obtained by Stereotactic Biopsy

1991 • 72 citations

Glutamate differentially inhibits the expression of class II MHC antigens on astrocytes and microglia.

1992 • 72 citations

Immune response gene products (Ia antigens) on glial and endothelial cells in virus-induced demyelination.

1987 • 67 citations

Major Histocompatibility.Complex Molecule Expression in the Human Central Nervous System: Immunohistochemical Analysis of 40 Patients

1988 • 65 citations

Multiple sclerosis: Oligodendrocytes in active lesions do not express class II major histocompatibility complex molecules

1989 • 60 citations

Microglia Present Myelin Antigens to T Cells after Phagocytosis of Oligodendrocytes

1993 • 60 citations

Exploiting the lacZ reporter gene for quantitative analysis of disseminated tumor growth within the brain: use of the lacZ gene product as a tumor antigen, for evaluation of antigenic modulation, and to facilitate image analysis of tumor growth in situ.

1993 • 59 citations

Expression and induction of intercellular adhesion molecules (ICAMs) and major histocompatibility complex (MHC) antigens on cultured murine oligodendrocytes and astrocytes

1991 • 58 citations

Effects of γ-interferon on major histocompatibility complex antigen expression and lymphocytic infiltration in the 9L gliosarcoma brain tumor model: implications for strategies of immunotherapy

1992 • 56 citations

Susceptibility of astrocytes to class I MHC antigen-specific cytotoxicity.

1987 • 56 citations

Comparison and quantitation of Ia antigen expression on cultured macroglia and ameboid microglia from Lewis rat cerebral cortex: analyses and implications

1989 • 56 citations

In vivo antigen presentation by both brain parenchymal cells and hematopoietically derived cells during the induction of experimental autoimmune encephalomyelitis.

1993 • 52 citations

Specific suppression of major histocompatibility complex class I and class II genes in astrocytes by brain-enriched gangliosides.

1993 • 49 citations

Regulation of MHC molecules on MBP positive oligodendrocytes in mice by IFN-γ and TNF-α

1991 • 44 citations

IFN-treated neuroblastoma cell lines remain resistant to T cell-mediated allo-killing, and susceptible to non-MHC-restricted cytotoxicity.

1988 • 43 citations

An H2-T MHC class Ib molecule presents Listeria monocytogenes-derived antigen to immune CD8+ cytotoxic T cells.

1994 • 42 citations

In the presence of dexamethasone, gamma interferon induces rat oligodendrocytes to express major histocompatibility complex class II molecules.

1992 • 42 citations

Identification of a specific HLA DR2 Ia molecule as a restriction element for measles virus-specific HLA class II-restricted cytotoxic T cell clones.

1985 • 42 citations

Early major histocompatibility complex (MHC) class I antigen induction in hypothalamic supraoptic and paraventricular nuclei in trypanosome-infected rats

1989 • 40 citations

Chapter 17 Allograft rejection overcome by immunoselection of neuronal precursor cells

1990 • 39 citations

Induction of class I and class II transplantation antigens in rat brain during fatal and non-fatal measles virus infection

1987 • 38 citations

Gamma interferon expression and major histocompatibility complex induction during measles and vesicular stomatitis virus infections of the brain

1991 • 37 citations

The Immunopathology of Acute Experimental Allergic Encephalomyelitis. IV. An Ultrastructural Immunocytochemical Study of Class II Major Histocompatibility Complex Molecule (Ia) Expression

1987 • 36 citations

MHC-specific cytotoxic T lymphocyte killing of dissociated sympathetic neuronal cultures.

1987 • 35 citations

Neurobiology of human oligodendrocytes in culture

1990 • 35 citations

Disseminating tumor cells and their interactions with leukocytes visualized in the brain.

1992 • 34 citations

Vasoactive intestinal polypeptide inhibits the expression of the MHC class II antigens on astrocytes

1988 • 33 citations

In situ Ia expression on brain cells in the rat: autoimmune encephalomyelitis-resistant strain (BN) and susceptible strain (Lewis) compared.

1989 • 32 citations

Detailed analysis of early immunopathologic events during lesion formation in acute experimental autoimmune encephalomyelitis

1989 • 32 citations

Differentiation of an immortalized CNS neuronal cell line decreases their susceptibility to cytotoxic T cell lysis in vitro

1994 • 30 citations

Interferon-Mediated Induction of Class I MHC Products in Human Neuronal Cell Lines: Analysis of HLA and β2-m RNA, and HLA-A and HLA-B Proteins and Polymorphic Specificities

1986 • 29 citations

Identification in rat liver and serum of water-soluble class I MHC molecules possibly homologous to the murine Q10 gene product.

1987 • 28 citations

Induction of HLA class I and class II expression in human T-lymphotropic virus type I-infected neuroblastoma cells

1994 • 28 citations

RESISTANCE AND SUSCEPTIBILITY OF NEURAL CELLS TO LYSIS BY CYTOTOXIC LYMPHOCYTES AND BY CYTOLYTIC GRANULES

1992 • 26 citations

Expression of mouse beta 2-microglobulin in frozen and formaldehyde-fixed central nervous tissues: comparison of tissue behind the blood-brain barrier and tissue in a barrier-free region.

1986 • 24 citations

Interferon-γ induced ia antigen expression on cultured neuroglial cells and brain macrophages from rat spinal cord and cerebrum

1991 • 22 citations

Chapter 31 Defining the mechanisms that govern immune acceptance or rejection of neural tissue

1988 • 21 citations

Persistence of measles virus in rat brain neurons is promoted by depletion of CD8+ T cells

1989 • 20 citations

Induction of class I major histocompatibility complex antigens on adult primate retinal neurons

1993 • 18 citations

Human neuroblastoma cell growth in xenogeneic hosts: comparison of T cell-deficient and NK-deficient hosts, and subcutaneous or intravenous injection routes

1990 • 17 citations

Long‐term survival of mouse corpus callosum grafts in neonatal rat recipients, and the effect of host sensitization

1992 • 17 citations

Extrathymic T-cell selection

1992 • 15 citations

MHC expression in nonlymphoid tissues of the developing embryo: Strongest class I or class II expression in separate populations of potential antigen-presenting cells in the skin, lung, gut, and inter-organ connective tissue

1995 • 15 citations

Enhanced T Cell Migration to Sites of Microscopic CNS Disease: Complementary Treatments Evaluated by 2‐ and 3‐D Image Analysis

1994 • 14 citations

MHC regulation in neural cells. Distribution of peripheral and internal beta 2-microglobulin and class I molecules in human neuroblastoma cell lines.

1990 • 14 citations

Distribution of beta 2-microglobulin in olfactory epithelium: a proliferating neuroepithelium not protected by a blood-tissue barrier.

1986 • 12 citations

Chapter 25 Class I and II MHC expression and its implications for regeneration in the nervous system

1994 • 10 citations

A transgenic mouse model to assess the interaction of cytotoxic T lymphocytes with virally infected, class I MHC-expressing astrocytes

1994 • 10 citations

Molecular Bases of Neuronal Individuality

1984 • 6 citations

Expression of Class I and II Major Histocompatibility Complex (MHC) Antigens in the Developing CNS

1992 • 6 citations