Inducible Nitric Oxide Synthase and Tumor Necrosis Factor-Alpha in Myocardium in Human Dilated Cardiomyopathy

Single-Step Method of RNA Isolation by Acid Guanidinium Thiocyanate–Phenol–Chloroform Extraction

1987 • 64,270 citations

Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction

1987 • 45,673 citations

Tumor Necrosis Factor (TNF)

1985 • 1,932 citations

Nitric oxide. A macrophage product responsible for cytostasis and respiratory inhibition in tumor target cells.

1989 • 1,747 citations

Control of Cachectin (Tumor Necrosis Factor) Synthesis: Mechanisms of Endotoxin Resistance

1986 • 1,305 citations

Tumor Necrosis Factor-α and Tumor Necrosis Factor Receptors in the Failing Human Heart

1996 • 993 citations

Nitric oxide: mediator, murderer, and medicine

1994 • 836 citations

Report of the WHO/ISFC task force on the definition and classification of cardiomyopathies.

1980 • 731 citations

Cellular basis for the negative inotropic effects of tumor necrosis factor-alpha in the adult mammalian heart.

1993 • 708 citations

Molecular structure of the human cytoplasmic beta-actin gene: interspecies homology of sequences in the introns.

1985 • 706 citations

Induction and potential biological relevance of a Ca²⁺‐independent nitric oxide synthase in the myocardium

1992 • 623 citations

DETECTION OF COXSACKIE-B-VIRUS-SPECIFIC RNA SEQUENCES IN MYOCARDIAL BIOPSY SAMPLES FROM PATIENTS WITH MYOCARDITIS AND DILATED CARDIOMYOPATHY

1986 • 605 citations

Expression of Inducible Nitric Oxide Synthase in Human Heart Failure

1996 • 496 citations

Cloning and expression in Escherichia coli of the gene for human tumour necrosis factor

1985 • 464 citations

Cytokine-inducible nitric oxide synthase (iNOS) expression in cardiac myocytes. Characterization and regulation of iNOS expression and detection of iNOS activity in single cardiac myocytes in vitro.

1994 • 436 citations

Tumor necrosis factor-alpha gene and protein expression in adult feline myocardium after endotoxin administration.

1995 • 436 citations

Tumour necrosis factor and inducible nitric oxide synthase in dilated cardiomyopathy

1996 • 365 citations

Tumor necrosis factor: a potent effector molecule for tumor cell killing by activated macrophages.

1986 • 360 citations

Nitric oxide synthase activities in human myocardium

1993 • 358 citations

Autoantibodies against beta-adrenoceptors in human idiopathic dilated cardiomyopathy.

1989 • 337 citations

Detection of enterovirus RNA in myocardial biopsies from patients with myocarditis and cardiomyopathy using gene amplification by polymerase chain reaction.

1990 • 316 citations

Identification of alpha- and beta-cardiac myosin heavy chain isoforms as major autoantigens in dilated cardiomyopathy.

1992 • 308 citations

Cloning, characterization, and expression of a cDNA encoding an inducible nitric oxide synthase from the human chondrocyte.

1993 • 302 citations

Interferon-gamma and tumor necrosis factor synergize to induce nitric oxide production and inhibit mitochondrial respiration in vascular smooth muscle cells.

1992 • 276 citations

The lethal effects of cytokine-induced nitric oxide on cardiac myocytes are blocked by nitric oxide synthase antagonism or transforming growth factor beta.

1995 • 251 citations

Nitric Oxide Inhibits the Positive Inotropic Response to β-Adrenergic Stimulation in Humans With Left Ventricular Dysfunction

1995 • 218 citations

Induction of Nitric Oxide Synthase in the Human Cardiac Allograft Is Associated With Contractile Dysfunction of the Left Ventricle

1996 • 155 citations

Induction of nitric oxide synthase gene by interleukin-1 beta in cultured rat cardiocytes.

1994 • 154 citations

The endocardial endothelium

1992 • 126 citations

Tumor necrosis factor production by human monocytes is a regulated event: induction of TNF-alpha-mediated cellular cytotoxicity by endotoxin.

1986 • 105 citations

Expression of Inducible Nitric Oxide Synthase in Failing and Non-failing Human Heart

1996 • 99 citations

Molecular probes for detection of persisting enterovirus infection of human heart and their prognostic value

1991 • 93 citations

New Concepts in Viral Heart Disease

1988 • 90 citations

Nitric oxide synthesis in cardiac myocytes and fibroblasts by inflammatory cytokines

1995 • 86 citations

Coxsackievirus B3-induced production of tumor necrosis factor-alpha, IL-1 beta, and IL-6 in human monocytes.

1992 • 86 citations

Expression of cytokine genes and presence of enteroviral genomic RNA in endomyocardial biopsy tissues of myocarditis and dilated cardiomyopathy

1996 • 78 citations

Nitric Oxide-Mediated Apoptosis in Murine Mastocytoma

1994 • 72 citations

Immunohistochemistry in the identification of nitric oxide synthase isoenzymes in myocardial infarction

1995 • 60 citations

Porcine ventricular endocardial cells in culture express the inducible form of nitric oxide synthase

1993 • 57 citations

Persistence of Enterovirus RNA in Dilated Cardiomyopathy: A Progression from Myocarditis

1988 • 45 citations

Nitric oxide synthesis in cardiac myocytes and fibroblasts by inflammatory cytokines

1995 • 44 citations

Inducible Nitric Oxide Synthase Activity in Myocardium After Myocardial Infarction in Rabbit

1994 • 40 citations

Tetrahydrobiopterin synthesis and inducible nitric oxide production in pulmonary artery smooth muscle

1994 • 39 citations

Nitric oxide and the pathogenesis of heart muscle disease

1995 • 30 citations

The fragile X syndrome: implications of molecular genetics for the clinical syndrome

1994 • 28 citations

Immunohistochemistry in the identification of nitric oxide synthase isoenzymes in myocardial infarction

1995 • 26 citations

Enteroviral RNA in dilated cardiomyopathy

1994 • 25 citations

Immune cytokines and cardiac disease

1992 • 24 citations