The lethal effects of cytokine-induced nitric oxide on cardiac myocytes are blocked by nitric oxide synthase antagonism or transforming growth factor beta.

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The L-Arginine-Nitric Oxide Pathway

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Elevated Circulating Levels of Tumor Necrosis Factor in Severe Chronic Heart Failure

1990 • 2,566 citations

Cloning and Characterization of Inducible Nitric Oxide Synthase from Mouse Macrophages

1992 • 1,914 citations

Nitric oxide. A macrophage product responsible for cytostasis and respiratory inhibition in tumor target cells.

1989 • 1,747 citations

Negative Inotropic Effects of Cytokines on the Heart Mediated by Nitric Oxide

1992 • 1,635 citations

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1990 • 1,284 citations

Mammalian nitrate biosynthesis: mouse macrophages produce nitrite and nitrate in response to Escherichia coli lipopolysaccharide.

1985 • 1,146 citations

Nitric Oxide Activation of Poly(ADP-Ribose) Synthetase in Neurotoxicity

1994 • 1,138 citations

The Cardiovascular Response of Normal Humans to the Administration of Endotoxin

1989 • 1,096 citations

A novel neuronal messenger molecule in brain: The free radical, nitric oxide

1992 • 837 citations

Inhibition of Viral Replication by Interferon-γ-Induced Nitric Oxide Synthase

1993 • 825 citations

Nitric oxide-mediated apoptosis in murine peritoneal macrophages

1993 • 782 citations

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1992 • 754 citations

Control of coronary vascular tone by nitric oxide.

1990 • 713 citations

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1993 • 674 citations

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1993 • 658 citations

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1993 • 656 citations

The 1991 Ulf von Euler Lecture:The <scp>l</scp>‐arginine: nitric oxide pathway

1992 • 654 citations

Expression of the nitric oxide synthase gene in mouse macrophages activated for tumor cell killing. Molecular basis for the synergy between interferon-gamma and lipopolysaccharide.

1993 • 623 citations

Induction and potential biological relevance of a Ca²⁺‐independent nitric oxide synthase in the myocardium

1992 • 623 citations

A circulating myocardial depressant substance in humans with septic shock. Septic shock patients with a reduced ejection fraction have a circulating factor that depresses in vitro myocardial cell performance.

1985 • 620 citations

Contrasting mechanisms for suppression of macrophage cytokine release by transforming growth factor-beta and interleukin-10

1992 • 516 citations

EPR demonstration of iron-nitrosyl complex formation by cytotoxic activated macrophages.

1990 • 512 citations

Interferon‐γ and tumor necrosis factor induce the L‐arginine‐dependent cytotoxic effector mechanism in murine macrophages^*

1988 • 511 citations

Evidence for cytokine-inducible nitric oxide synthesis from L-arginine in patients receiving interleukin-2 therapy.

1992 • 494 citations

Interleukin 1 and tumor necrosis factor inhibit cardiac myocyte beta-adrenergic responsiveness.

1989 • 493 citations

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1993 • 482 citations

Evidence for antiviral effect of nitric oxide. Inhibition of herpes simplex virus type 1 replication.

1993 • 470 citations

Abnormal contractile function due to induction of nitric oxide synthesis in rat cardiac myocytes follows exposure to activated macrophage-conditioned medium.

1993 • 457 citations

The microbicidal activity of interferon‐γ‐treated macrophages against Trypanosoma cruzi involves an L‐arginine‐dependent, nitrogen oxide‐mediated mechanism inhibitable by interleukin‐10 and transforming growth factor‐β

1992 • 437 citations

Inhibition of tumor cell ribonucleotide reductase by macrophage-derived nitric oxide.

1991 • 436 citations

Nitric oxide attenuates cardiac myocyte contraction

1993 • 405 citations

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1994 • 374 citations

Nitric oxide synthase activities in human myocardium

1993 • 358 citations

Nitric oxide production within cardiac myocytes reduces their contractility in endotoxemia

1992 • 327 citations

An L-arginine-dependent mechanism mediates kupffer cell inhibition of hepatocyte protein synthesis in vitro

1989 • 325 citations

The causes of dilated cardiomyopathy: A clinicopathologic review of 673 consecutive patients

1994 • 301 citations

Generation of EPR-detectable nitrosyl-iron complexes in tumor target cells cocultured with activated macrophages

1991 • 280 citations

Interferon-gamma and tumor necrosis factor synergize to induce nitric oxide production and inhibit mitochondrial respiration in vascular smooth muscle cells.

1992 • 276 citations

Cytokine gene transcription in vascularised organ grafts: analysis using semiquantitative polymerase chain reaction.

1991 • 267 citations

Activated macrophages kill pancreatic syngeneic islet cells via arginine-dependent nitric oxide generation

1991 • 257 citations

Pathophysiological correlates of increased serum tumor necrosis factor in patients with congestive heart failure. Relation to nitric oxide-dependent vasodilation in the forearm circulation.

1994 • 219 citations

Mechanism of cytokine inhibition of beta-adrenergic agonist stimulation of cyclic AMP in rat cardiac myocytes. Impairment of signal transduction.

1990 • 215 citations

Induction of myocardial nitric oxide synthase by cardiac allograft rejection.

1994 • 212 citations

EPR detection of heme and nonheme iron-containing protein nitrosylation by nitric oxide during rejection of rat heart allograft.

1992 • 195 citations

IFN-γ-activated macrophages: Detection by electron paramagnetic resonance of complexes between L-Arginine-derived nitric oxide and non-heme iron proteins

1990 • 185 citations

Nitric oxide synthase in cultured endocardial cells of the pig

1991 • 164 citations

Vesnarinone, a new inotropic agent, inhibits cytokine production by stimulated human blood from patients with heart failure.

1994 • 156 citations

Induction of nitric oxide synthase gene by interleukin-1 beta in cultured rat cardiocytes.

1994 • 154 citations

Role of nitric oxide in antagonistic effects of transforming growth factor-beta and interleukin-1 beta on the beating rate of cultured cardiac myocytes.

1992 • 150 citations

Nitric oxide mediates interleukin-1-induced cellular cytotoxicity in the rat ovary. A potential role for nitric oxide in the ovulatory process.

1993 • 147 citations

Cardiac preservation is enhanced in a heterotopic rat transplant model by supplementing the nitric oxide pathway.

1994 • 141 citations

Mechanisms of immune-mediated myocyte injury.

1994 • 141 citations

Nitric oxide mediates tumor necrosis factor-α cytotoxicity in endothelial cells

1992 • 127 citations

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Endothelial cells are activated by cytokine treatment to kill an intravascular parasite, Schistosoma mansoni, through the production of nitric oxide.

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Effects of 8-Bromo-cyclic GMP on contraction and on inotropic response of ferret cardiac muscle

1991 • 101 citations

The induction of nitric oxide synthase activity is inhibited by TGF-β1, PDGFAB and PDGFBB in vascular smooth muscle cells

1992 • 96 citations

Adjustment of the osmolality of Percoll for the isopycnic separation of cells and cell organelles

1984 • 95 citations

Interleukin-1β induces nitric oxide production and inhibits the activity of aconitase without decreasing glucose oxidation rates in isolated mouse pancreatic islets

1992 • 91 citations

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Myocardial Toxic Effects During Recombinant Interleukin-2 Therapy

1989 • 80 citations

Recombinant alpha2 interferon-related cardiomyopathy

1988 • 79 citations

Role of basal release of nitric oxide on coronary flow and mechanical performance of the isolated rat heart.

1992 • 79 citations

Nitric Oxide Mediates IL-1β-Induced Islet Dysfunction and Destruction: Prevention by Dexamethasone

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Biosynthesis And Metabolism Of Endothelium-Derived Nitric Oxide

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Effects of E. coli endotoxemia on ventricular performance

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Exogenous nitric oxide (NO) generation or IL-1 beta-induced intracellular NO production stimulates inhibitory auto-ADP-ribosylation of glyceraldehyde-3-phosphate dehydrogenase in RINm5F cells.

1993 • 66 citations

Effects of interleukin 2 on cardiac function in the isolated rat heart.

1990 • 63 citations

Macrophages Produce Nitric Oxide at Allograft Sites

1993 • 59 citations

Interferon-gamma and tumor necrosis factor-alpha exert their antirickettsial effect via induction of synthesis of nitric oxide.

1993 • 57 citations

Inhibition of cytokine‐induced nitric oxide production by transforming growth factor‐beta 1 in human smooth muscle cells.

1992 • 54 citations

A new method for assessment of cultured cardiac myocyte contractility detects immune factor-mediated inhibition of beta-adrenergic responses.

1991 • 51 citations

MYOCARDIAL INJURY AFTER INTERLEUKIN-2 THERAPY

1988 • 21 citations

Does the heart fail in endotoxin shock?

1990 • 15 citations

Isolated cardiomyocytes in conjunction with NMR spectroscopy techniques to study metabolism and ion flux.

1992 • 14 citations

Characterization of mononuclear cell infiltrates in human cardiac allografts.

1984 • 8 citations

Recombinant alpha2 interferon-related cardiomyopathy

1988 • 7 citations

Graft-infiltrating cell nitric oxide production is stimulated by TNF alpha.

1992 • 3 citations