Innate immunity and heat shock response in islet transplantation

Innate Immune Recognition

2002 • 8,157 citations

Islet Transplantation in Seven Patients with Type 1 Diabetes Mellitus Using a Glucocorticoid-Free Immunosuppressive Regimen

2000 • 5,125 citations

Toll-like receptors: critical proteins linking innate and acquired immunity

2001 • 4,673 citations

Toll-like receptors in the induction of the innate immune response

2000 • 3,052 citations

International Trial of the Edmonton Protocol for Islet Transplantation

2006 • 1,869 citations

The Dynamic Life of Natural Killer Cells

2004 • 565 citations

Production of tissue factor by pancreatic islet cells as a trigger of detrimental thrombotic reactions in clinical islet transplantation

2002 • 552 citations

Incompatibility between human blood and isolated islets of Langerhans: a finding with implications for clinical intraportal islet transplantation?

1999 • 418 citations

Interplay of natural killer cells and their receptors with the adaptive immune response

2004 • 404 citations

NK cells in innate immunity

2004 • 307 citations

Human Pancreatic Islets Produce and Secrete MCP-1/CCL2: Relevance in Human Islet Transplantation

2002 • 285 citations

Heme Oxygenase-1 Induction in Islet Cells Results in Protection From Apoptosis and Improved In Vivo Function After Transplantation

2001 • 263 citations

Inhibition of Thrombin Abrogates the Instant Blood-Mediated Inflammatory Reaction Triggered by Isolated Human Islets

2002 • 259 citations

Transplantation of allogeneic islets of Langerhans in the rat liver: effects of macrophage depletion on graft survival and microenvironment activation.

1998 • 244 citations

DAMAGE TO PORCINE ISLETS OF LANGERHANS AFTER EXPOSURE TO HUMAN BLOOD IN VITRO, OR AFTER INTRAPORTAL TRANSPLANTATION TO CYNOMOLOGUS MONKEYS

2000 • 201 citations

Islet transplantation in patients with autoimmune diabetes induces homeostatic cytokines that expand autoreactive memory T cells

2008 • 192 citations

NK cells promote islet allograft tolerance via a perforin-dependent mechanism

2005 • 187 citations

Rapid loss of intraportally transplanted islets: an overview of pathophysiology and preventive strategies

2007 • 170 citations

Heat shock protein hsp70 overexpression confers resistance against nitric oxide

1996 • 163 citations

Heat shock induces resistance in rat pancreatic islet cells against nitric oxide, oxygen radicals and streptozotocin toxicity in vitro.

1995 • 156 citations

Vascular Endothelial Growth Factor Increases Functional β-Cell Mass by Improvement of Angiogenesis of Isolated Human and Murine Pancreatic Islets

2005 • 150 citations

Therapeutic Applications of Bilirubin and Biliverdin in Transplantation

2007 • 129 citations

Nicotinamide inhibits tissue factor expression in isolated human pancreatic islets: implications for clinical islet transplantation1

2003 • 126 citations

An Integral Role for Heme Oxygenase-1 and Carbon Monoxide in Maintaining Peripheral Tolerance by CD4+CD25+ Regulatory T Cells

2005 • 120 citations

Selected Contribution: Effect of acute heat shock on gene expression by human peripheral blood mononuclear cells

2002 • 110 citations

Low molecular weight dextran sulfate prevents the instant blood-mediated inflammatory reaction induced by adult porcine islets

2004 • 108 citations

Blocking the Monocyte Chemoattractant Protein-1/CCR2 Chemokine Pathway Induces Permanent Survival of Islet Allografts through a Programmed Death-1 Ligand-1-Dependent Mechanism

2003 • 108 citations

Heme oxygenase‐1, carbon monoxide, and bilirubin induce tolerance in recipients toward islet allografts by modulating T regulatory cells

2007 • 108 citations

Heat Shock Inhibits Cytokine-Induced Nitric Oxide Synthase Expression by Rat and Human Islets**This work was supported by research grants from the NIH (DK-52194) and The Tobacco Research Council

1998 • 105 citations

Vα14 NK T cell–triggered IFN-γ production by Gr-1+CD11b+ cells mediates early graft loss of syngeneic transplanted islets

2005 • 103 citations

The Role of CC Chemokine Receptor 5 (CCR5) in Islet Allograft Rejection

2002 • 94 citations

Heme oxygenase-1 (HO-1), a protective gene that prevents chronic graft dysfunction

2004 • 93 citations

Heme Oxygenase-1 Protects Pancreatic β Cells from Apoptosis Caused by Various Stimuli

2001 • 92 citations

A Protective Role for Heme Oxygenase Expression in Pancreatic Islets Exposed to Interleukin-1β**This work was supported by NIH Grant DK-25705 (to S.G.L.).

1998 • 91 citations

Neutrophilic granulocytes are the predominant cell type infiltrating pancreatic islets in contact with ABO-compatible blood

2005 • 88 citations

A Novel Small-Molecule Compound Targeting CCR5 and CXCR3 Prevents Acute and Chronic Allograft Rejection

2005 • 88 citations

Donor Treatment With Carbon Monoxide Can Yield Islet Allograft Survival and Tolerance

2005 • 87 citations

Acute Antibody-Mediated Complement Activation Mediates Lysis of Pancreatic Islets Cells and May Cause Tissue Loss in Clinical Islet Transplantation

2008 • 86 citations

Chemokine mediated control of dendritic cell migration and function

2003 • 84 citations

Reduction of Early Graft Loss After Intraportal Porcine Islet Transplantation in Monkeys

2007 • 84 citations

Natural Resistance of Human Beta Cells toward Nitric Oxide Is Mediated by Heat Shock Protein 70

2000 • 83 citations

Association between macrophage activation and function of micro-encapsulated rat islets

2003 • 81 citations

Differential Role of CCR2 in Islet and Heart Allograft Rejection: Tissue Specificity of Chemokine/Chemokine Receptor Function In Vivo

2004 • 78 citations

Prolongation of Cardiac and Islet Allograft Survival by a Blocking Hamster Anti-Mouse CXCR3 Monoclonal Antibody

2008 • 77 citations

Ischaemia is linked to inflammation and induction of angiogenesis in pancreatic islets

2006 • 77 citations

Genetic deletion of chemokine receptor CXCR3 or antibody blockade of its ligand IP-10 modulates posttransplantation graft-site lymphocytic infiltrates and prolongs functional graft survival in pancreatic islet allograft recipients

2003 • 74 citations

Cytokine signalling in the β-cell: a dual role for IFNγ

2008 • 71 citations

Heme oxygenase-1 fused to a TAT peptide transduces and protects pancreatic β-cells

2003 • 68 citations

Composite Islet‐Endothelial Cell Grafts: A Novel Approach to Counteract Innate Immunity in Islet Transplantation

2005 • 68 citations

Minimization of Immunosuppressive Therapy After Islet Transplantation: Combined Action of Heme Oxygenase-1 and PEGylation to Islet

2006 • 63 citations

Macrophage depletion improves survival of porcine neonatal pancreatic cell clusters contained in alginate macrocapsules transplanted into rats

2003 • 63 citations

Carbon monoxide stimulates insulin release and propagates Ca²⁺signals between pancreatic β-cells

2003 • 62 citations

Mitochondrial and Cellular Heme-Dependent Proteins as Targets for the Bioactive Function of the Heme Oxygenase/Carbon Monoxide System

2007 • 58 citations

Adult porcine islets produce MCP‐1 and recruit human monocytes in vitro

2004 • 55 citations

Heme Oxygenase: A Target Gene for Anti-Diabetic and Obesity

2008 • 51 citations

Heme oxygenase-1 in organ transplantation

2007 • 50 citations

Immune mechanisms associated with the rejection of encapsulated neonatal porcine islet xenografts

2006 • 47 citations

The Role of the Innate Immunity in Islet Transplantation

2005 • 46 citations

Characterization of Donor Dendritic Cells and Enhancement of Dendritic Cell Efflux With cc-Chemokine Ligand 21

2007 • 43 citations

Human NK cell and ADCC reactivity against xenogeneic porcine target cells including fetal porcine islet cells

1998 • 39 citations

The role of chemokines and their receptors in the rejection of pig islet tissue xenografts

2003 • 38 citations

Role of Donor-Derived Monocyte Chemoattractant Protein-1 in Murine Islet Transplantation

2004 • 38 citations

Adverse outcome of human islet-allogeneic blood interaction1,2

2003 • 36 citations

Progress towards clinical xenotransplantation

2007 • 34 citations

Heme Oxygenase-1 and Transplantation Tolerance

2006 • 32 citations

Neonatal porcine islet cells induce human CD4+, but not CD8+, lymphocyte proliferation and resist cell-mediated cytolytic injury in vitro.

1999 • 30 citations

Macrophage Depletion Prolongs Discordant but not Concordant Islet Xenograft Survival

2005 • 30 citations

Low Stress Response Enhances Vulnerability of Islet Cells in Diabetes-Prone BB Rats

1997 • 29 citations

A Protective Role for Heme Oxygenase-1 in INS-1 Cells and Rat Islets that are Exposed to High Glucose Conditions

2006 • 29 citations

Permanent Survival of Fully MHC-Mismatched Islet Allografts by Targeting a Single Chemokine Receptor Pathway

2005 • 26 citations

Chemokine and toll‐like receptor signaling in macrophage mediated islet xenograft rejection

2007 • 24 citations

IL-10 Gene Modified Dendritic Cells Inhibit T Helper Type 1-Mediated Alloimmune Responses and Promote Immunological Tolerance in Diabetes

2008 • 21 citations

Phenotypic and Functional Differences Between Wild-Type and CCR2−/− Dendritic Cells: Implications for Islet Transplantation

2008 • 20 citations

Requirement of MyD88 for Macrophage-Mediated Islet Xenograft Rejection After Adoptive Transfer

2007 • 19 citations

Influence of heme oxygenase-1 gene transfer on the viability and function of rat islets inin vitroculture

2007 • 19 citations

Transplantation of Rat Islets Transduced With Human Heme Oxygenase-1 Gene Using Adenovirus Vector

2006 • 18 citations

Pretransplant Induction of HSP-70 in Isolated Adult Pig Islets Decreases Early Islet Xenograft Survival

2000 • 16 citations

Involvement of CCR5 Signaling in Macrophage Recruitment to Porcine Islet Xenografts

2005 • 16 citations

Hyperthermic Preconditioning Protects Pig Islet Grafts from Early Inflammation but Enhances Rejection in Immunocompetent Mice

2003 • 15 citations

Prolonged Islet Allograft Survival in Diabetic Mice Upon Macrophage Depletion by Clodronate-Loaded Erythrocytes

2008 • 14 citations

Platelets at the Interface between Hemostasis and Innate Immunity

2004 • 13 citations

Stress Response of Pancreatic Islets from Diabetes Prone BB Rats of Different Age

2002 • 12 citations

Heat shock preconditioning impairs revascularization of freely transplanted pancreatic islets1

2002 • 12 citations

Interaction of poly(styrene sulfonic acid) with the alternative pathway of the serum complement system

2005 • 11 citations

Heme Oxygenase-1 and Transplantation

2004 • 10 citations

IL-12p40-overexpressing immature dendritic cells induce T cell hyporesponsiveness in vitro but accelerate allograft rejection in vivo: role of NK cell activation and interferon-gamma production

2004 • 10 citations

Both Innate and Adaptive Major Histocompatibility Complex Class I-Dependent Immunity Impair Long-Term Islet Xenograft Survival

2008 • 9 citations

Effect of Pretransplant Preconditioning by Whole Body Hyperthermia on Islet Graft Survival

2007 • 7 citations

Blocking the CC Chemokine Receptor 5 Pathway by Antisense Peptide Nucleic Acid Prolongs Islet Allograft Survival

2007 • 7 citations

Interaction of poly(styrene sulfonic acid) with the classical pathway of the serum complement system

2005 • 6 citations

Late CD8+ T Cell-Dependent Xenoantibody Production in Innate Tolerant Nude Rats After Hamster Islet Grafting But Not After Hamster Heart Grafting

2008 • 5 citations

Role of CD4+ and CD8+ T cells in the rejection of heart or islet xenografts in recipients with xenotolerance in the innate immune compartment

2005 • 4 citations

Deleted Work

1955 • 0 citations