Heat shock induces resistance in rat pancreatic islet cells against nitric oxide, oxygen radicals and streptozotocin toxicity in vitro.

Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

1970 • 253,849 citations

Short-Term Effects of Nose-Only Cigarette Smoke Exposure on Glutathione Redox Homeostasis, Cytochrome P450 1A1/2 and Respiratory Enzyme Activities in Mice Tissues

2013 • 47,043 citations

Mammalian stress response: cell physiology, structure/function of stress proteins, and implications for medicine and disease

1992 • 1,201 citations

Conserved features of eukaryotic hsp70 genes revealed by comparison with the nucleotide sequence of human hsp70.

1985 • 860 citations

The Heat Shock Respons

1985 • 809 citations

Streptozotocin and alloxan induce DNA strand breaks and poly(ADP–ribose) synthetase in pancreatic islets

1981 • 530 citations

Cellular and biochemical events in mammalian cells during and after recovery from physiological stress.

1986 • 513 citations

CuZn-superoxide dismutase, Mn-superoxide dismutase, catalase and glutathione peroxidase in pancreatic islets and other tissues in the mouse

1981 • 502 citations

Hydrogen peroxide-induced injury of cells and its prevention by inhibitors of poly(ADP-ribose) polymerase.

1986 • 466 citations

Studies on the Diabetogenic Action of Streptozotocin (NSC37917)

1963 • 442 citations

Inhibition of insulin secretion by interleukin‐1β and tumour necrosis factor‐α via an L‐arginine‐dependent nitric oxide generating mechanism

1990 • 362 citations

Does Nitric Oxide Mediate Autoimmune Destruction of β-Cells?: Possible Therapeutic Interventions in IDDM

1992 • 299 citations

Determinants of the selective toxicity of alloxan to the pancreatic B cell.

1982 • 280 citations

Protection by superoxide dismutase, catalase, and poly(ADP-ribose) synthetase inhibitors against alloxan- and streptozotocin-induced islet DNA strand breaks and against the inhibition of proinsulin synthesis.

1982 • 251 citations

Heat-shock proteins protect cells from monocyte cytotoxicity: possible mechanism of self-protection.

1993 • 223 citations

Preventive and Therapeutic Effects of Large-Dose Nicotinamide Injections on Diabetes Associated with Insulitis: An Observation in Nonobese Diabetic (NOD) Mice

1982 • 221 citations

Biochemical Evidence for Nitric Oxide Formation from Streptozotocin in Isolated Pancreatic Islets

1993 • 215 citations

A simple ultramicro method for determination of pyridine nucleotides in tissues

1969 • 196 citations

Nitric Oxide Toxicity in Islet Cells Involves Poly(ADP-Ribose) Polymerase Activation and Concomitant NAD+ Depletion

1994 • 188 citations

Cell cycle-dependent association of HSP70 with specific cellular proteins.

1989 • 145 citations

Mechanisms of pancreatic beta-cell destruction in type I diabetes.

1988 • 145 citations

Spontaneous cytotoxicity of macrophages against pancreatic islet cells.

1989 • 115 citations

Pancreatic B cells possess defense mechanisms against cell-specific toxicity.

1986 • 115 citations

Analysis of TNF alpha-induced DNA strand breaks at the single cell level.

1991 • 111 citations

Emerging Role of Heat Shock Proteins in Biology and Medicine

1992 • 107 citations

Pancreatic islet cells are highly susceptible towards the cytotoxic effects of chemically generated nitric oxide

1993 • 103 citations

Toxicity of chemically generated nitric oxide towards pancreatic islet cells can be prevented by nicotinamide

1992 • 102 citations

Heat shock protein induction in rat pancreatic islets by recombinant human interleukin 1?

1991 • 85 citations

Liposomal Delivery of Purified Heat Shock Protein hsp70 Into Rat Pancreatic Islets as Protection Against Interleukin 1β–Induced Impaired β-Cell Function

1991 • 84 citations

Type 1 (insulin-dependent) diabetes mellitus and nitric oxide

1992 • 84 citations

Lymphocyte dysfunction after DNA damage by toxic oxygen species. A model of immunodeficiency.

1986 • 81 citations

Immunocytochemical localization of heat-shock protein 60-related protein in Beta-cell secretory granules and its altered distribution in non-obese diabetic mice

1992 • 68 citations

Oxygen radicals generated by the enzyme xanthine oxidase lyse rat pancreatic islet cells in vitro

1992 • 63 citations

Heat stress induces hsc70/nuclear topoisomerase Icomplex formation in vivo: evidence for hsc70-mediated, ATP-independentreactivation in vitro.

1994 • 51 citations

Significance of streptozotocin induced nicotinamide‐adenine‐dinucleotide (NAD) degradation in mouse pancreatic islets

1973 • 44 citations

Direct stimulation of poly(ADP ribose) polymerase in permeabilized cells by double-stranded DNA oligomers

1991 • 40 citations

Analysis of Oxygen Radical Toxicity in Pancreatic Islets at the Single Cell Level

1994 • 40 citations

No Independent Association Between HSP70 Gene Polymorphism and IDDM

1992 • 28 citations

Insulitis-Caused Redistribution of Heat-Shock Protein HSP60 Inside β-cells Correlates With Induction of HSP60 Autoantibodies

1993 • 27 citations

Synthesis of hsp-70 Is Enhanced in Glutathione-Depleted Hep G2 Cells

1993 • 27 citations

Relationships between thermotolerance, oxidative stress responses and induction of stress proteins in human tumour cell lines

1992 • 18 citations

No independent association between HSP70 gene polymorphism and IDDM

1992 • 18 citations

The immunobiology of heat shock proteins.

1991 • 12 citations