Immune mechanisms associated with the rejection of encapsulated neonatal porcine islet xenografts

Islet Transplantation in Seven Patients with Type 1 Diabetes Mellitus Using a Glucocorticoid-Free Immunosuppressive Regimen

2000 • 5,125 citations

Immunobiology: the immune system in health and disease

1995 • 3,893 citations

Relationship between interferon‐γ, indoleamine 2,3‐dioxygenase, and tryptophan catabolism

1991 • 1,018 citations

Long-term survival of neonatal porcine islets in nonhuman primates by targeting costimulation pathways

2006 • 468 citations

Large scale isolation, growth, and function of porcine neonatal islet cells.

1996 • 358 citations

Survival of adult islet grafts from transgenic pigs with N‐acetylglucosaminyltransferase‐III (GnT‐III) in cynomolgus monkeys

2005 • 139 citations

Interferons and indoleamine 2,3-dioxygenase: Role in antimicrobial and antitumor effects

1989 • 139 citations

THE ROLE OF CD4+ HELPER T CELLS IN THE DESTRUCTION OF MICROENCAPSULATED ISLET XENOGRAFTS IN NOD MICE

1990 • 127 citations

T Cell-Activated Macrophages Are Capable of Both Recognition and Rejection of Pancreatic Islet Xenografts

2003 • 106 citations

CD4+ T CELL MEDIATED DESTRUCTION OF XENOGRAFTS WITHIN CELL-IMPERMEABLE MEMBRANES IN THE ABSENCE OF CD8+ T CELLS AND B CELLS1

1996 • 90 citations

Survival of Microencapsulated Adult Pig Islets in Mice In Spite of an Antibody Response

2004 • 88 citations

Pig islet xenograft rejection is markedly delayed in macrophage‐depleted mice: a study in streptozotocin diabetic animals

2000 • 71 citations

Reversal of Diabetes in Pancreatectomized Pigs After Transplantation of Neonatal Porcine Islets

2005 • 64 citations

Macrophage depletion improves survival of porcine neonatal pancreatic cell clusters contained in alginate macrocapsules transplanted into rats

2003 • 63 citations

MICROENCAPSULATION OF NEONATAL PORCINE ISLETS: PROTECTION FROM HUMAN ANTIBODY/COMPLEMENT-MEDIATED CYTOLYSIS IN VITRO AND LONG-TERM REVERSAL OF DIABETES IN NUDE MICE1

2000 • 50 citations

CD4+ T CELLS INITIATE PANCREATIC ISLET XENOGRAFT REJECTION VIA AN INTERFERON-??-DEPENDENT RECRUITMENT OF MACROPHAGES AND NATURAL KILLER CELLS1

2002 • 48 citations

Analysis of the cellular reaction towards microencapsulated xenogeneic islets after intraperitoneal transplantation

1999 • 48 citations

In Vivo Recognition by the Host Adaptive Immune System of Microencapsulated Xenogeneic Cells

2004 • 47 citations

The Degree of Phylogenetic Disparity of Islet Grafts Dictates the Reliance on Indirect CD4 T-Cell Antigen Recognition for Rejection

2003 • 43 citations

Prolonged Survival of Microencapsulated Neonatal Porcine Islets in Mice Treated with a Combination of Anti-CD154 and Anti-LFA-1 Monoclonal Antibodies

2005 • 30 citations

Protection of Xenografts by a Combination of Immunoisolation and a Single Dose of Anti-CD4 Antibody

2001 • 23 citations

Rapid Destruction of Encapsulated Islet Xenografts by NOD Mice is CD4-Dependent and Facilitated by B-cells: Innate Immunity and Autoimmunity Do Not Play Significant Roles

2005 • 20 citations

Humoral response to encapsulated islets.

1994 • 9 citations