Stress Response of Pancreatic Islets from Diabetes Prone BB Rats of Different Age

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THE HEAT-SHOCK RESPONSE

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Heat Shock Is Lethal to Fibroblasts Microinjected with Antibodies Against hsp70

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Stress proteins, infection, and immune surveillance

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Human major histocompatibility complex contains genes for the major heat shock protein HSP70.

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A combination of HLA-DQ beta Asp57-negative and HLA DQ alpha Arg52 confers susceptibility to insulin-dependent diabetes mellitus.

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Differences in the Expression of Heat-Shock Proteins and Antioxidant Enzymes between Human and Rodent Pancreatic Islets: Implications for the Pathogenesis of Insulin-Dependent Diabetes Mellitus

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Heat shock induces resistance in rat pancreatic islet cells against nitric oxide, oxygen radicals and streptozotocin toxicity in vitro.

1995 • 156 citations

Islet cell autoantigens in insulin-dependent diabetes.

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Polymorphic Analysis of the Human MHC‐Linked Heat Shock Protein 70 (HSP70‐2) and HSP70‐Hom Genes in Insulin‐Dependent Diabetes Mellitus (IDDM)

1993 • 124 citations

Hsp72-mediated augmentation of MHC class I surface expression and endogenous antigen presentation

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How the Cell Copes with Stress and the Function of Heat Shock Proteins

1994 • 101 citations

Comparative analysis of the three major histocompatibility complex-linked heat shock protein 70 (Hsp70) genes of the rat

1994 • 86 citations

Liposomal Delivery of Purified Heat Shock Protein hsp70 Into Rat Pancreatic Islets as Protection Against Interleukin 1β–Induced Impaired β-Cell Function

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Natural Resistance of Human Beta Cells toward Nitric Oxide Is Mediated by Heat Shock Protein 70

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Localization of heat shock protein 70 genes inside the rat major histocompatibility complex close to class III genes

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Conservation of the central MHC genome: PFGE mapping and RFLP analysis of complement, HSP70, and TNF genes in the goat

1990 • 57 citations

BB/O(ttawa)K(arlsburg) rats: features of a subline of diabetes-prone BB rats.

1991 • 53 citations

New insights suggesting a possible role of a heat shock protein 70-kD family-related protein in antigen processing/presentation phenomenon in humans

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Localization of a mouse heat shock Hsp70 gene within the H-2 complex

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Enhanced susceptibility to cytotoxic T lymphocytes without increase of MHC class I antigen expression after conditional overexpression of heat shock protein 70 in target cells

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Measurement of Insulin in Human Sera Using a New RIA Kit. 1. Insulin Determination in the Absence of Insulin Antibodies — Conventional Assay and Micro Modification²)

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Differential expression of heat shock proteins 70-1 and 70-2 mRNA after ischemia-reperfusion injury of rat kidney

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Studies on Autoimmunity for Initiation of β-Cell Destruction: VII. Evidence for Antigenic Changes on β-Cells Leading to Autoimmune Destruction of β-Cells in BB Rats

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Low Stress Response Enhances Vulnerability of Islet Cells in Diabetes-Prone BB Rats

1997 • 29 citations

Repair of pancreatic beta-cells. A relevant phenomenon in early IDDM?

1993 • 26 citations

The Endocrine Pancreas of BB/OK-Rats before and at Diagnosis of Hyperglycaemia

2009 • 18 citations

Lipid Peroxidation and the Expressional Regulation of the Heat-Shock Response during Ischemia-Reperfusion of Rat Kidney

2000 • 18 citations

Heat-induced expression of MHC-linked HSP70 genes in lymphocytes varies at the single-cell level

1999 • 18 citations

No independent association between HSP70 gene polymorphism and IDDM

1992 • 18 citations

In Vitro Inhibition of Insulin Release by Blood Mononuclear Cells from Insulin-Dependent Diabetic and Healthy Subjects: Synergistic Action of IL-1 and TNF

1994 • 14 citations

Low stress response enhances vulnerability of islet cells in diabetes-prone BB rats

1997 • 13 citations

A Novel Monoclonal Antibody Directed Against the Heat-Inducible 68 kDa Heat Shock Protein

1991 • 12 citations

Early appearance of complement-dependent antibody mediated cytotoxicity (C'AMC) to islet cells in serum of diabetes-prone BB/OK rats.

1990 • 9 citations

Differences between LEW rats and their congenic LEW.1A and LEW.1W strains in body weight gain, plasma glucose and some hematologic traits--short communication.

1987 • 8 citations

Detection and time course of humoral-mediated cytotoxicity to different cell types in diabetes-prone BB/OK rats.

1991 • 7 citations

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Beta‐cell expression of 65‐kDa heat‐shock protein mRNA is function‐ and age‐dependent

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RT1-linked heat shock protein 70 genes.

1993 • 5 citations

Perspectives in Diabetes Repair of Pancreatic p-Cells A Relevant Phenomenon in Early IDDM?

1993 • 4 citations

New insights suggesting a possible role of a heat shock protein 70-kD family-related protein in antigen processing/presentation phenomenon in humans

1993 • 3 citations

Cell-Mediated Immune Reactions against Islets of Langerhans in Diabetes-Prone BB Rats

2009 • 3 citations

Heat‐induced expression of MHC‐linked HSP70 genes in lymphocytes varies at the single‐cell level

1999 • 1 citations

Lessons from Animal Models Regarding Pathogenesis of Insulin-Dependent Diabetes mellitus

2015 • 1 citations