DAMAGE TO PORCINE ISLETS OF LANGERHANS AFTER EXPOSURE TO HUMAN BLOOD IN VITRO, OR AFTER INTRAPORTAL TRANSPLANTATION TO CYNOMOLOGUS MONKEYS

P-selectin induces the expression of tissue factor on monocytes.

1994 • 595 citations

Islet isolation assessment in man and large animals

1990 • 575 citations

Transplantation of porcine fetal pancreas to diabetic patients

1994 • 555 citations

Blockade of C5a and C5b-9 generation inhibits leukocyte and platelet activation during extracorporeal circulation.

1995 • 217 citations

COMPLEMENT IN ORGAN TRANSPLANTATION CONTRIBUTIONS TO INFLAMMATION, INJURY, AND REJECTION

1995 • 189 citations

The response of human platelets to activated components of the complement system

1991 • 175 citations

A Method for the Mass Isolation of Islets From the Adult Pig Pancreas

1986 • 171 citations

Contributions of human platelets to the proteolytic activation of blood coagulation factors XII and XI

1981 • 160 citations

Scientific and Political Impediments to Successful Islet Transplantation

1997 • 140 citations

Platelet activation by C1q results in the induction of alpha IIb/beta 3 integrins (GPIIb-IIIa) and the expression of P-selectin and procoagulant activity.

1993 • 131 citations

Generation of iC3 at the Interface between Blood and Gas

1992 • 128 citations

LARGE-SCALE PRODUCTION OF FETAL PORCINE PANCREATIC ISLETLIKE CELL CLUSTERS

1988 • 112 citations

Studies of Adsorption, Activation, and Inhibition of Factor XII on Immobilized Heparin

1998 • 99 citations

Distribution of collagens type I, type III and type V in the pancreas of rat, dog, pig and man

1994 • 99 citations

Participation of protein kinases in complement C5b-9-induced shedding of platelet plasma membrane vesicles

1991 • 97 citations

Effects of complement inhibition with soluble complement receptor-1 on vascular injury and inflammation during renal allograft rejection in the rat.

1996 • 93 citations

FETAL PORCINE ISLET-LIKE CELL CLUSTERS TRANSPLANTED TO CYNOMOLGUS MONKEYS

1999 • 80 citations

Tubing loops as a model for cardiopulmonary bypass circuits: Both the biomaterial and the blood-gas phase interfaces induce complement activation in anin vitro model

1996 • 78 citations

The Contribution Of Terminal Complement Components To Acute And Hyperacute Allograft Rejection In The Rat

1995 • 69 citations

Therapeutic Regulation of the Complement System in Acute Injury States

1994 • 64 citations

HUMAN COMPLEMENT ACTIVATION VIA THE ALTERNATIVE PATHWAY ON PORCINE ENDOTHELIUM INITIATED BY IgA ANTIBODIES

1995 • 53 citations

IMMEDIATE DESTRUCTION OF XENOGENEIC ISLETS IN A PRIMATE MODEL

1994 • 53 citations

Complement proteins C5b-9 initiate secretion of platelet storage granules without increased binding of fibrinogen or von Willebrand factor to newly expressed cell surface GPIIb-IIIa.

1988 • 51 citations

HYPERACUTE XENOGRAFT REJECTION IN THE SWINE -TO -HUMAN DONOR-RECIPIENT COMBINATION

1994 • 51 citations

INTACT PIG PANCREATIC ISLET FUNCTION IN THE PRESENCE OF HUMAN XENOREACTIVE NATURAL ANTIBODY BINDING AND COMPLEMENT ACTIVATION1

1997 • 51 citations

Inhibition of complement activation by soluble recombinant CR1 under conditions resembling those in a cardiopulmonary circuit: reduced up-regulation of CD11b and complete abrogation of binding of PMNs to the biomaterial surface

1997 • 48 citations

PORCINE ISLET CELLS OF LANGERHANS ARE DESTROYED BY HUMAN COMPLEMENT AND NOT BY ANTIBODY-DEPENDENT CELL-MEDIATED MECHANISMS1

1996 • 43 citations

Antigen presentation at the inflammatory site.

1989 • 40 citations

An Assessment of the Extent of Antigenic Analogy between Physiologically Bound C3 and C3 Denatured by Sodium Dodecyl Sulphate

1985 • 38 citations

Amount and distribution of collagen in pancreatic tissue of different species in the perspective of islet isolation procedures

1995 • 36 citations

P-Selectin Induction of Tissue Factor Biosynthesis and Expression

1996 • 30 citations

Functional characterization of platelet-bound factor XIa: retention of factor XIa activity on the platelet surface

1986 • 30 citations

The fate of intraportally transplanted islets in diabetic rats. A morphologic and immunohistochemical study.

1978 • 29 citations

Amount and Distribution of Collagen in Pancreatic Tissue of Different Species in the Perspective of Islet Isolation Procedures

1995 • 24 citations

Functional characterization of platelet-bound factor XIa: retention of factor XIa activity on the platelet surface

1986 • 22 citations

Immunohistological studies of complement activation after xenogeneic perfusion of a working heart model

1994 • 16 citations

IgM, IgG, and IgA antibodies in human sera directed against porcine islets of Langerhans.

1993 • 15 citations

Immunohistological studies of complement activation after xenogeneic perfusion of a working heart model

1994 • 10 citations

Effect of complement activation in human serum on isolated porcine islets

1996 • 8 citations

Tissue culture prevents hyperacute rejection of islet xenografts

1995 • 4 citations