Induction of tumor necrosis factor alpha production by human hepatocytes in chronic viral hepatitis.

The Pathophysiology of Tumor Necrosis Factors

1992 • 1,880 citations

A novel form of TNF/cachectin is a cell surface cytotoxic transmembrane protein: Ramifications for the complex physiology of TNF

1988 • 1,105 citations

Production of hepatitis B virus particles in Hep G2 cells transfected with cloned hepatitis B virus DNA.

1987 • 1,098 citations

[22] Detection of messenger RNA by in Situ hybridization to tissue sections and whole mounts

1993 • 807 citations

Tumor necrosis factor alpha induces expression of human immunodeficiency virus in a chronically infected T-cell clone.

1989 • 726 citations

Human keratinocytes are a source for tumor necrosis factor alpha: evidence for synthesis and release upon stimulation with endotoxin or ultraviolet light.

1990 • 707 citations

Increased serum levels of tumor necrosis factor alpha precede major complications of bone marrow transplantation [see comments]

1990 • 591 citations

Hepatocytes produce nitrogen oxides from L-arginine in response to inflammatory products of Kupffer cells.

1989 • 405 citations

Molecular cloning and expression of human tumor necrosis factor and comparison with mouse tumor necrosis factor

1985 • 240 citations

The tissue distribution of tumor necrosis factor biosynthesis during endotoxemia.

1992 • 228 citations

Cellular and humoral immune reactions in chronic active liver disease. I. Lymphocyte subsets in liver biopsies of patients with untreated idiopathic autoimmune hepatitis, chronic active hepatitis B and primary biliary cirrhosis.

1982 • 182 citations

Induction of tumor necrosis factor expression and resistance in a human breast tumor cell line.

1987 • 137 citations

A novel addition to the T cell repertory. Cell surface expression of tumor necrosis factor/cachectin by activated normal human T cells.

1990 • 133 citations

Involvement of the cytotoxic/suppressor T-cell subset in liver tissue injury of patients with acute and chronic liver diseases

1983 • 129 citations

Genes for IFN-beta-2 (IL-6), tumor necrosis factor, and IL-1 are expressed at high levels in the organs of normal individuals.

1988 • 119 citations

I. EVIDENCE THAT ELEVATED LEVELS OF TUMOR NECROSIS FACTOR-ALPHA PREDICT REJECTION FOLLOWING ORTHOTOPIC LIVER TRANSPLANTATION

1990 • 118 citations

Endotoxin-induced cytokine gene expression in vivo. II. Regulation of tumor necrosis factor and interleukin-1 alpha/beta expression and suppression.

1990 • 109 citations

Nonhematopoietic cells selected for resistance to tumor necrosis factor produce tumor necrosis factor.

1986 • 108 citations

Tumor necrosis factor‐α production induced in T lymphocytes through the AIM/CD69 activation pathway

1992 • 97 citations

Expression of a novel activation antigen on intrahepatic CD8+ T lymphocytes in viral chronic active hepatitis

1990 • 92 citations

Distribution of ICAM-3-bearing cells in normal human tissues. Expression of a novel counter-receptor for LFA-1 in epidermal Langerhans cells.

1993 • 84 citations

Constitutive activity of the tumor necrosis factor promoter is canceled by the 3' untranslated region in nonmacrophage cell lines; a trans-dominant factor overcomes this suppressive effect.

1992 • 71 citations

Tumor necrosis factor-alpha and IFN-gamma expression in human thymus. Localization and overexpression in Down syndrome (trisomy 21).

1992 • 70 citations

Trans-activation of HLA-DR gene by hepatitis B virus X gene product.

1990 • 69 citations

Different functional sites on rIFN-alpha 2 and their relation to the cellular receptor binding site.

1987 • 25 citations

Regulation of tumor necrosis factor (TNF)‐α synthesis and TNF receptors expression in T lymphocytes through the CD2 activation pathway

1992 • 24 citations

Intrahepatic up-regulated expression of extracellular matrix protein receptors in chronic active hepatitis type B

1992 • 19 citations