Activity of the Nurr1 Carboxyl-terminal Domain Depends on Cell Type and Integrity of the Activation Function 2

The RXR heterodimers and orphan receptors

1995 • 3,168 citations

The Structural Basis of Estrogen Receptor/Coactivator Recognition and the Antagonism of This Interaction by Tamoxifen

1998 • 2,622 citations

Sequence and Characterization of a Coactivator for the Steroid Hormone Receptor Superfamily

1995 • 2,390 citations

Ligand binding and co-activator assembly of the peroxisome proliferator-activated receptor-γ

1998 • 1,902 citations

Steroid hormone receptors: Many Actors in search of a plot

1995 • 1,854 citations

Direct repeats as selective response elements for the thyroid hormone, retinoic acid, and vitamin D3 receptors

1991 • 1,725 citations

The transcriptional co-activator p/CIP binds CBP and mediates nuclear-receptor function

1997 • 1,300 citations

Steroid receptor coactivator-1 is a histone acetyltransferase

1997 • 1,245 citations

Dopamine Neuron Agenesis in Nurr1-Deficient Mice

1997 • 1,075 citations

Nonsteroid nuclear receptors: What Are genetic studies telling us about their role in real life?

1995 • 1,011 citations

Multipotent neural cell lines can engraft and participate in development of mouse cerebellum

1992 • 928 citations

Structure and specificity of nuclear receptor–coactivator interactions

1998 • 922 citations

Coactivator and corepressor complexes in nuclear receptor function

1999 • 909 citations

Interleukin-4-dependent production of PPAR-γ ligands in macrophages by 12/15-lipoxygenase

1999 • 835 citations

The nuclear receptor ligand-binding domain: structure and function

1998 • 829 citations

Identification of a conserved region required for hormone dependent transcriptional activation by steroid hormone receptors.

1992 • 829 citations

Nurr1 is essential for the induction of the dopaminergic phenotype and the survival of ventral mesencephalic late dopaminergic precursor neurons

1998 • 725 citations

Nerve growth factor induces a gene homologous to the glucocorticoid receptor gene

1988 • 661 citations

Unique response pathways are established by allosteric interactions among nuclear hormone receptors

1995 • 629 citations

Hormone-Dependent Coactivator Binding to a Hydrophobic Cleft on Nuclear Receptors

1998 • 580 citations

A novel pathway for vitamin A signaling mediated by RXR heterodimerization with NGFI-B and NURR1.

1995 • 548 citations

A possible involvement of TIF1 alpha and TIF1 beta in the epigenetic control of transcription by nuclear receptors.

1996 • 532 citations

The TRAP220 component of a thyroid hormone receptor- associated protein (TRAP) coactivator complex interacts directly with nuclear receptors in a ligand-dependent fashion

1998 • 454 citations

Increasing the Complexity of Coactivation in Nuclear Receptor Signaling

1999 • 449 citations

Regulation of retinoid signalling by receptor polarity and allosteric control of ligand binding

1994 • 432 citations

The orphan receptors NGFI-B and steroidogenic factor 1 establish monomer binding as a third paradigm of nuclear receptor-DNA interaction.

1993 • 397 citations

A novel protein complex that interacts with the vitamin D₃ receptor in a ligand-dependent manner and enhances VDR transactivation in a cell-free system

1998 • 391 citations

Identification of a new brain-specific transcription factor, NURR1.

1992 • 373 citations

Induction of a midbrain dopaminergic phenotype in Nurr1-overexpressing neural stem cells by type 1 astrocytes

1999 • 373 citations

Activation function 2 (AF-2) of retinoic acid receptor and 9-cis retinoic acid receptor: presence of a conserved autonomous constitutive activating domain and influence of the nature of the response element on AF-2 activity.

1994 • 354 citations

Retinoids Selective for Retinoid X Receptor Response Pathways

1992 • 342 citations

Cellular expression of the immediate early transcription factors Nurr1 and NGFI-B suggests a gene regulatory role in several brain regions including the nigrostriatal dopamine system

1996 • 334 citations

Characterization of the ligand-dependent transactivation domain of thyroid hormone receptor.

1994 • 324 citations

Dopamine Biosynthesis Is Selectively Abolished in Substantia Nigra/Ventral Tegmental Area but Not in Hypothalamic Neurons in Mice with Targeted Disruption of the Nurr1 Gene

1998 • 291 citations

The orphan nuclear receptor LXRα is positively and negatively regulated by distinct products of mevalonate metabolism

1997 • 282 citations

Retinoid X receptor heterodimerization and developmental expression distinguish the orphan nuclear receptors NGFI-B, Nurr1, and Nor1.

1996 • 233 citations

AF-2 Activity and Recruitment of Steroid Receptor Coactivator 1 to the Estrogen Receptor Depend on a Lysine Residue Conserved in Nuclear Receptors

1997 • 214 citations

Two distinct actions of retinoid-receptor ligands

1996 • 200 citations

Molecular Cloning of a Novel Thyroid/Steroid Receptor Superfamily Gene from Cultured Rat Neuronal Cells

1994 • 187 citations

Transactivation by Retinoid X Receptor–Peroxisome Proliferator-Activated Receptor γ (PPARγ) Heterodimers: Intermolecular Synergy Requires Only the PPARγ Hormone-Dependent Activation Function

1998 • 183 citations

Retinoid X Receptor (RXR) within the RXR-Retinoic Acid Receptor Heterodimer Binds Its Ligand and Enhances Retinoid-Dependent Gene Expression

1997 • 167 citations

Unique requirements for retinoid-dependent transcriptional activation by the orphan receptor LXR.

1997 • 166 citations

Activation of specific RXR heterodimers by an antagonist of RXR homodimers

1996 • 164 citations

The NGFI-B subfamily of the nuclear receptor superfamily (review).

1998 • 145 citations

Dominant Activity of Activation Function 1 (AF-1) and Differential Stoichiometric Requirements for AF-1 and -2 in the Estrogen Receptor α-β Heterodimeric Complex

1999 • 138 citations

A mutation mimicking ligand-induced conformational change yields a constitutive RXR that senses allosteric effects in heterodimers

1997 • 135 citations

Activation and Repression by Nuclear Hormone Receptors: Hormone Modulates an Equilibrium between Active and Repressive States

1996 • 135 citations

The phantom ligand effect: allosteric control of transcription by the retinoid X receptor.

1997 • 128 citations

Functional domains and phosphorylation of the orphan receptor Nur77.

1993 • 128 citations

Functional analysis of a transactivation domain in the thyroid hormone beta receptor.

1994 • 123 citations

Interactions between the retinoid X receptor and a conserved region of the TATA-binding protein mediate hormone-dependent transactivation.

1995 • 118 citations

A natural transactivation mutation in the thyroid hormone β receptor: Impaired interaction with putative transcriptional mediators

1997 • 117 citations

Cooperativity in transactivation between retinoic acid receptor and TFIID requires an activity analogous to E1A

1992 • 116 citations

Domains regulating transcriptional activity of the inducible orphan receptor NGFI-B.

1992 • 110 citations

Mutations in the 1,25-Dihydroxyvitamin D3 Receptor Identifying C-terminal Amino Acids Required for Transcriptional Activation That Are Functionally Dissociated from Hormone Binding, Heterodimeric DNA Binding, and Interaction with Basal Transcription Factor IIB, in Vitro

1997 • 91 citations

Retinoic Acid Receptor/Retinoid X Receptor Heterodimers Can Be Activated through Both Subunits Providing a Basis for Synergistic Transactivation and Cellular Differentiation

1997 • 82 citations

Adenovirus E1A Functions as a Cofactor for Retinoic Acid Receptor β (RAR β) through Direct Interaction with RARβ

1995 • 45 citations

The Adenovirus E1A Protein Is a Potent Coactivator for Thyroid Hormone Receptors

1999 • 27 citations

Point Mutation in the Ligand-Binding Domain of the Progesterone Receptor Generates a Transdominant Negative Phenotype

1997 • 16 citations