Point Mutation in the Ligand-Binding Domain of the Progesterone Receptor Generates a Transdominant Negative Phenotype

Recombinant genomes which express chloramphenicol acetyltransferase in mammalian cells.

1982 • 8,069 citations

Tight control of gene expression in mammalian cells by tetracycline-responsive promoters.

1992 • 4,885 citations

Gene regulation by steroid hormones

1989 • 3,466 citations

A rapid micrqpreparation technique for extraction of DNA-binding proteins from limiting numbers of mammalian cells

1991 • 2,362 citations

Ligand-independent repression by the thyroid hormone receptor mediated by a nuclear receptor co-repressor

1995 • 2,059 citations

Steroid hormone receptors: Many Actors in search of a plot

1995 • 1,854 citations

Primary structure and expression of a functional human glucocorticoid receptor cDNA

1985 • 1,851 citations

A transcriptional co-repressor that interacts with nuclear hormone receptors

1995 • 1,744 citations

Two distinct estrogen-regulated promoters generate transcripts encoding the two functionally different human progesterone receptor forms A and B.

1990 • 1,510 citations

Crystal structure of the ligand-binding domain of the human nuclear receptor RXR-α

1995 • 1,179 citations

TIF2, a 160 kDa transcriptional mediator for the ligand-dependent activation function AF-2 of nuclear receptors.

1996 • 1,095 citations

Crystal structure of the RAR-γ ligand-binding domain bound to all-trans retinoic acid

1995 • 1,085 citations

High level transient expression of a chloramphenicol acetyl transferase gene by DEAE-dextran mediated DNA transfection coupled with a dimethyl sulfoxide or glycerol shock treatment

1984 • 898 citations

Identification of a conserved region required for hormone dependent transcriptional activation by steroid hormone receptors.

1992 • 829 citations

Human progesterone receptor A form is a cell- and promoter-specific repressor of human progesterone receptor B function.

1993 • 749 citations

Glucocorticoid receptor beta, a potential endogenous inhibitor of glucocorticoid action in humans.

1995 • 636 citations

The Human Glucocorticoid Receptor β Isoform

1996 • 553 citations

The N-terminal region of the chicken progesterone receptor specifies target gene activation

1988 • 425 citations

Complete amino acid sequence of the human progesterone receptor deduced from cloned cDNA

1987 • 419 citations

Differential ligand-dependent interactions between the AF-2 activating domain of nuclear receptors and the putative transcriptional intermediary factors mSUG1 and TIF1.

1996 • 410 citations

Synergistic action of the glucocorticoid receptor with transcription factors.

1988 • 407 citations

Progesterone-binding Components of Chick Oviduct

1971 • 389 citations

The mechanism of RU486 antagonism is dependent on the conformation of the carboxy-terminal tail of the human progesterone receptor

1992 • 381 citations

Interaction of proteins with transcriptionally active estrogen receptors.

1994 • 379 citations

Progesterone-binding Components of Chick Oviduct

1972 • 372 citations

The A and B isoforms of the human progesterone receptor operate through distinct signaling pathways within target cells.

1994 • 343 citations

Agonistic and antagonistic activities of RU486 on the functions of the human progesterone receptor.

1990 • 333 citations

Glucocorticoid-binding Proteins of Rat Liver Cytosol

1972 • 328 citations

A third transactivation function (AF3) of human progesterone receptors located in the unique N-terminal segment of the B-isoform.

1994 • 313 citations

Hormone induces binding of receptors and transcription factors to a rearranged nucleosome on the MMTV promoter in vivo.

1995 • 313 citations

Steroid receptor analyses of nine human breast cancer cell lines.

1978 • 300 citations

Cooperative binding of steroid hormone receptors contributes to transcriptional synergism at target enhancer elements

1989 • 270 citations

Control of transcription activation by steroid hormone receptors

1992 • 218 citations

New T47D breast cancer cell lines for the independent study of progesterone B- and A-receptors: only antiprogestin-occupied B-receptors are switched to transcriptional agonists by cAMP.

1994 • 214 citations

Differential gene activation by glucocorticoids and progestins through the hormone regulatory element of mouse mammary tumor virus

1988 • 205 citations

A limiting factor mediates the differential activation of promoters by the human progesterone receptor isoforms.

1992 • 171 citations

Transient expression of human and chicken progesterone receptors does not support alternative translational initiation from a single mRNA as the mechanism generating two receptor isoforms.

1990 • 146 citations

A Single Amino Acid That Determines the Sensitivity of Progesterone Receptors to RU486

1992 • 141 citations

Powerful dominant negative mutants of the human estrogen receptor

1993 • 119 citations

A nuclear hormone receptor-associated protein that inhibits transactivation by the thyroid hormone and retinoic acid receptors.

1995 • 97 citations

The involvement of p23, hsp90, and immunophilins in the assembly of progesterone receptor complexes

1996 • 79 citations

Analysis of Mechanisms That Determine Dominant Negative Estrogen Receptor Effectiveness

1995 • 73 citations

Structure-Function Properties of the Chicken Progesterone Receptor A Synthesized from Complementary Deoxyribonucleic Acid

1987 • 60 citations

Functional interaction of hybrid response elements with wild-type and mutant steroid hormone receptors.

1991 • 60 citations

A conserved carboxy-terminal subdomain is important for ligand interpretation and transactivation by nuclear receptors.

1994 • 58 citations

Interplay of steroid hormone receptors and transcription factors on the mouse mammary tumor virus promoter

1992 • 53 citations

Repression of endogenous estrogen receptor activity in MCF-7 human breast cancer cells by dominant negative estrogen receptors.

1995 • 41 citations

Hormonal Regulation of Vitellogenin Genes: An Estrogen-Responsive Element in theXenopusA2 Gene and a Multihormonal Regulatory Region in the Chicken II Gene

1991 • 32 citations

Characterization of the progesterone receptor of rabbit uterus with the synthetic progestin 16α-ethyl-21-hydroxy-19-norpregn-4-ene-3,20-dione

1978 • 29 citations

Hormone-dependent Transactivation by Estrogen Receptor Chimeras That Do Not Interact with hsp90

1996 • 27 citations

The Molecular Biology of Progesterone Receptors: Why Are There Two Isoforms?

1997 • 1 citations