Mechanisms Underlying Caloric Restriction and Lifespan Regulation

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Oxidative Stress, Caloric Restriction, and Aging

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Sirt1 promotes fat mobilization in white adipocytes by repressing PPAR-γ

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2001 • 1,892 citations

Calorie Restriction Promotes Mammalian Cell Survival by Inducing the SIRT1 Deacetylase

2004 • 1,877 citations

Requirement of NAD and SIR2 for Life-Span Extension by Calorie Restriction in Saccharomyces cerevisiae

2000 • 1,756 citations

Functions of Ceramide in Coordinating Cellular Responses to Stress

1996 • 1,620 citations

Genomic Instability and Aging-like Phenotype in the Absence of Mammalian SIRT6

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Role of Free Radicals in the Neurodegenerative Diseases

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Basal Lipid Peroxidation in Substantia Nigra Is Increased in Parkinson's Disease

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Mammalian SIRT1 Represses Forkhead Transcription Factors

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The Endocrine Regulation of Aging by Insulin-like Signals

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Sir2 mediates longevity in the fly through a pathway related to calorie restriction

2004 • 1,337 citations

Calorie restriction, SIRT1 and metabolism: understanding longevity

2005 • 1,005 citations

SIRT1 Functionally Interacts with the Metabolic Regulator and Transcriptional Coactivator PGC-1α

2005 • 994 citations

Curcumin activates the haem oxygenase-1 gene via regulation of Nrf2 and the antioxidant-responsive element

2003 • 989 citations

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Long-term calorie restriction is highly effective in reducing the risk for atherosclerosis in humans

2004 • 874 citations

Human SIR2 deacetylates p53 and antagonizes PML/p53-induced cellular senescence

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Oxidative DNA Damage in the Parkinsonian Brain: An Apparent Selective Increase in 8‐Hydroxyguanine Levels in Substantia Nigra

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SIRT1 promotes endothelium-dependent vascular relaxation by activating endothelial nitric oxide synthase

2007 • 809 citations

Oxidative damage, mitochondrial oxidant generation and antioxidant defenses during aging and in response to food restriction in the mouse

1994 • 785 citations

Resveratrol Prolongs Lifespan and Retards the Onset of Age-Related Markers in a Short-Lived Vertebrate

2006 • 763 citations

Calorie Restriction Increases Muscle Mitochondrial Biogenesis in Healthy Humans

2007 • 761 citations

Decline in transcriptional activity of Nrf2 causes age-related loss of glutathione synthesis, which is reversible with lipoic acid

2004 • 739 citations

Insulin and insulin-like growth factor expression and function deteriorate with progression of Alzheimer's disease: Link to brain reductions in acetylcholine

2005 • 696 citations

Calorie restriction induces mitochondrial biogenesis and bioenergetic efficiency

2006 • 664 citations

A Diet Enriched with the Omega-3 Fatty Acid Docosahexaenoic Acid Reduces Amyloid Burden in an Aged Alzheimer Mouse Model

2005 • 659 citations

Free radicals and aging

2004 • 658 citations

SirT2 is a histone deacetylase with preference for histone H4 Lys 16 during mitosis

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SIRT1 Deacetylates and Positively Regulates the Nuclear Receptor LXR

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Aging-Induced Phenotypic Changes and Oxidative Stress Impair Coronary Arteriolar Function

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Cardiac Stem Cell and Myocyte Aging, Heart Failure, and Insulin-Like Growth Factor-1 Overexpression

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Cardiac Stem Cells Possess Growth Factor-Receptor Systems That After Activation Regenerate the Infarcted Myocardium, Improving Ventricular Function and Long-Term Survival

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Overexpression of insulin-like growth factor-1 in mice protects from myocyte death after infarction, attenuating ventricular dilation, wall stress, and cardiac hypertrophy.

1997 • 496 citations

Oxidative stress and protein aggregation during biological aging

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Nicotinamide adenine dinucleotide, a metabolic regulator of transcription, longevity and disease

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Action of Nrf2 and Keap1 in ARE-mediated NQO1 expression by quercetin

2007 • 449 citations

Increased oxidative damage in nuclear and mitochondrial DNA in Alzheimer's disease

2005 • 427 citations

Resveratrol upregulates heme oxygenase-1 expression via activation of NF-E2-related factor 2 in PC12 cells

2005 • 421 citations

Calorie restriction mimetics: an emerging research field

2006 • 403 citations

The role of ascorbate in antioxidant protection of biomembranes: Interaction with vitamin E and coenzyme Q

1994 • 402 citations

Cytokines, insulin-like growth factor 1, sarcopenia, and mortality in very old community-dwelling men and women: the Framingham Heart Study

2003 • 394 citations

Sir2 Blocks Extreme Life-Span Extension

2005 • 380 citations

Long-Term Caloric Restriction Ameliorates the Decline in Diastolic Function in Humans

2006 • 367 citations

Nutritional Influences on Aging of Fischer 344 Rats: II. Pathology

1985 • 356 citations

Dietary restriction in Drosophila

2005 • 350 citations

The interaction between FOXO and SIRT1: tipping the balance towards survival

2004 • 339 citations

Improvements in glucose tolerance and insulin action induced by increasing energy expenditure or decreasing energy intake: a randomized controlled trial

2006 • 339 citations

Effects of a Low–Glycemic Load Diet on Resting Energy Expenditure and Heart Disease Risk Factors During Weight Loss

2004 • 331 citations

Oxidative damage to protein in sporadic motor neuron disease spinal cord

1995 • 326 citations

Interleukin-6 and aging: blood levels and mononuclear cell production increase with advancing age and in vitro production is modifiable by dietary restriction.

1993 • 322 citations

Increased mitochondrial H₂O₂ production promotes endothelial NF-κB activation in aged rat arteries

2007 • 321 citations

Laminar Flow Induction of Antioxidant Response Element-mediated Genes in Endothelial Cells

2003 • 319 citations

SIRT1 is critical regulator of FOXO-mediated transcription in response to oxidative stress

2005 • 308 citations

Long-term effects of 2 energy-restricted diets differing in glycemic load on dietary adherence, body composition, and metabolism in CALERIE: a 1-y randomized controlled trial

2007 • 306 citations

Deletion of p66 ^shc Gene Protects Against Age-Related Endothelial Dysfunction

2004 • 282 citations

Effect of Calorie Restriction with or without Exercise on Body Composition and Fat Distribution

2007 • 280 citations

Muscle fiber‐specific apoptosis and TNF‐α signaling in sarcopenia are attenuated by life‐long calorie restriction

2005 • 277 citations

Resveratrol attenuates TNF-α-induced activation of coronary arterial endothelial cells: role of NF-κB inhibition

2006 • 270 citations

Aging‐induced proinflammatory shift in cytokine expression profile in rat coronary arteries

2003 • 265 citations

Calorie restriction up-regulates the plasma membrane redox system in brain cells and suppresses oxidative stress during aging

2006 • 260 citations

Membrane Fatty Acid Unsaturation, Protection against Oxidative Stress, and Maximum Life Span

2002 • 258 citations

Mammalian SIRT1 limits replicative life span in response to chronic genotoxic stress

2005 • 257 citations

Calorie restriction or exercise: effects on coronary heart disease risk factors. A randomized, controlled trial

2007 • 255 citations

Caloric restriction prevents age-associated accrual of oxidative damage to mouse skeletal muscle mitochondria

1998 • 253 citations

Ageing, oxidative stress, and mitochondrial uncoupling

2004 • 252 citations

Free radicals, proteins and DNA: oxidative damage versus redox regulation

1996 • 242 citations

THE INFLUENCE OF DIET ON TRANSPLANTED AND SPONTANEOUS MOUSE TUMORS

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Biomechanical Forces in Atherosclerosis-Resistant Vascular Regions Regulate Endothelial Redox Balance via Phosphoinositol 3-Kinase/Akt-Dependent Activation of Nrf2

2007 • 236 citations

Dietary restriction increases insulin sensitivity and lowers blood glucose in rhesus monkeys

1994 • 235 citations

Cardioprotection by Intermittent Fasting in Rats

2005 • 231 citations

Resveratrol increases vascular oxidative stress resistance

2007 • 230 citations

Aging in vertebrates, and the effect of caloric restriction: a mitochondrial free radical production–DNA damage mechanism?

2004 • 229 citations

Calorie restriction inhibits the age-related dysregulation of the cytokines TNF-α and IL-6 in C3B10RF1 mice

1997 • 221 citations

Mitochondrial dysfunction in neurodegenerative disorders

1998 • 211 citations

Restriction of energy intake, energy expenditure, and aging

2000 • 211 citations

Vasculoprotective Effects of Anti-Tumor Necrosis Factor-α Treatment in Aging

2007 • 210 citations

The calorically restricted low-fat nutrient-dense diet in Biosphere 2 significantly lowers blood glucose, total leukocyte count, cholesterol, and blood pressure in humans.

1992 • 209 citations

Proinflammatory phenotype of coronary arteries promotes endothelial apoptosis in aging

2004 • 204 citations

Development of Calorie Restriction Mimetics as a Prolongevity Strategy

2004 • 199 citations

Effect of weight loss on some serum cytokines in human obesity: increase in IL-10 after weight loss

2007 • 198 citations

Weight Reduction With Very-Low-Caloric Diet and Endothelial Function in Overweight Adults: Role of Plasma Glucose

2003 • 196 citations

Long-term caloric restriction increases UCP3 content but decreases proton leak and reactive oxygen species production in rat skeletal muscle mitochondria

2005 • 175 citations

Coenzyme Q reductase from liver plasma membrane: purification and role in trans-plasma-membrane electron transport.

1995 • 172 citations

The Initiation and Growth of Tumors. Introduction. I. Effects of Underfeeding.

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The expression of SIRT1 in nonalcoholic fatty liver disease induced by high‐fat diet in rats

2007 • 168 citations

Selective induction of apoptosis by capsaicin in transformed cells: the role of reactive oxygen species and calcium

1999 • 165 citations

Reduced release of nitric oxide to shear stress in mesenteric arteries of aged rats

2004 • 164 citations

Aging Decreases Electron Transport Complex III Activity in Heart Interfibrillar Mitochondria by Alteration of the Cytochrome c Binding Site

2001 • 162 citations

Shear stress stabilizes NF-E2-related factor 2 and induces antioxidant genes in endothelial cells: Role of reactive oxygen/nitrogen species

2006 • 159 citations

Up-regulation of the plasma membrane oxidoreductase as a prerequisite for the viability of human Namalwa rho 0 cells.

1994 • 155 citations

The importance of plasma membrane coenzyme Q in aging and stress responses

2007 • 150 citations

Calorie restriction attenuates age-related alterations in the plasma membrane antioxidant system in rat liver

2004 • 145 citations

Insulin-Like Growth Factor-1 Attenuates the Detrimental Impact of Nonocclusive Coronary Artery Constriction on the Heart

1999 • 135 citations

Ceramide induces apoptosis via CPP32 activation

1996 • 133 citations

A low-calorie diet improves endothelium-dependent vasodilation in obese patients with essential hypertension

2002 • 132 citations

Plasma Membrane Redox Systems and their Role in Biological Stress and Disease

1998 • 130 citations

Oxidative Stress: The Old Enemy in Alzheimers Disease Pathophysiology

2005 • 130 citations

Vitamin E and selenium deficiency induces expression of the ubiquinone‐dependent antioxidant system at the plasma membrane

1998 • 130 citations

The Effects of Diet, ad Libitum Feeding, and Moderate and Severe Dietary Restriction on Body Weight, Survival, Clinical Pathology Parameters, and Cause of Death in Control Sprague-Dawley Rats

2000 • 126 citations

C. elegans 14-3-3 proteins regulate life span and interact with SIR-2.1 and DAF-16/FOXO

2006 • 122 citations

Dietary restriction reduces atherosclerosis and oxidative stress in the aorta of apolipoprotein E-deficient mice

2002 • 116 citations

Sirt1: a metabolic master switch that modulates lifespan

2006 • 114 citations

An in vitro model of caloric restriction

2003 • 114 citations

Syntheses of Nicotinamide Riboside and Derivatives: Effective Agents for Increasing Nicotinamide Adenine Dinucleotide Concentrations in Mammalian Cells

2007 • 112 citations

Role of Oxidative and Nitrosative Stress, Longevity Genes and Poly(ADPribose) Polymerase in Cardiovascular Dysfunction Associated with Aging

2005 • 112 citations

Overexpression of Insulin-Like Growth Factor-1 Attenuates the Myocyte Renin-Angiotensin System in Transgenic Mice

1999 • 109 citations

Oxidative damage to mitochondrial DNA in spinal motoneurons of transgenic ALS mice

2001 • 108 citations

Induction of Quinone Reductase NQO1 by Resveratrol in Human K562 Cells Involves the Antioxidant Response Element ARE and is Accompanied by Nuclear Translocation of Transcription Factor Nrf2

2006 • 106 citations

Alteration of soluble adhesion molecules during aging and their modulation by calorie restriction

2003 • 104 citations

NAD(P)H oxidase-generated superoxide anion accounts for reduced control of myocardial O₂ consumption by NO in old Fischer 344 rats

2003 • 102 citations

Relation of oxidative protein damage and nitrotyrosine levels in the aging rat brain

2001 • 98 citations

Cardiac-specific overexpression of insulin-like growth factor 1 attenuates aging-associated cardiac diastolic contractile dysfunction and protein damage

2006 • 98 citations

Calorie Restriction Improves Cardiovascular Risk Factors via Reduction of Mitochondrial Reactive Oxygen Species in Type II Diabetic Rats

2006 • 96 citations

Biochemical and Biophysical Markers of Endothelial Dysfunction in Adults with Hypopituitarism and Severe GH Deficiency

2001 • 85 citations

Resveratrol attenuates TNFalfa‐induced activation of coronary arterial endothelial cells: role of NF‐kB inhibition

2007 • 84 citations

C-reactive protein and coronary artery disease: influence of obesity, caloric restriction and weight loss

2002 • 84 citations

Effects of Caloric Restriction and Exercise on Age-Related, Chronic Inflammation Assessed by C-Reactive Protein and Interleukin-6

2006 • 82 citations

Disturbed Cross Talk between Insulin-Like Growth Factor I and AMP-Activated Protein Kinase as a Possible Cause of Vascular Dysfunction in the Amyloid Precursor Protein/Presenilin 2 Mouse Model of Alzheimer's Disease

2007 • 81 citations

Calorie restriction delays lipid oxidative damage in Drosophila melanogaster

2005 • 81 citations

High rates of extracellular superoxide generation by cultured human fibroblasts: involvement of a lipid-metabolizing enzyme

1996 • 79 citations

Vascular Inflammation in Aging

2004 • 75 citations

Age-associated increases in the activity of multiple caspases in Fisher 344 rat organs

2002 • 74 citations

New advances on structural and biological functions of ceramide in apoptotic/necrotic cell death and cancer

2002 • 72 citations

Short-term CR decreases cardiac mitochondrial oxidant production but increases carbonyl content

2004 • 68 citations

Effects of age and food restriction on oxidative DNA damage and antioxidant enzyme activities in the mouse aorta

2001 • 67 citations

Up-regulation of plasma membrane-associated redox activities in neuronal cells lacking functional mitochondria

2006 • 66 citations

Caloric restriction increases HDL₂levels in rhesus monkeys (Macaca mulatta)

1997 • 66 citations

Effect of insulin and growth hormone on rat heart and liver oxidative stress in control and caloric restricted animals

2005 • 66 citations

Upregulation of Aortic Adhesion Molecules During Aging

2006 • 64 citations

Ceramide-dependent Caspase 3 Activation is Prevented by Coenzyme Q from Plasma Membrane in Serum-deprived Cells

2002 • 60 citations

Intracellular redox status affects transplasma membrane electron transport in pulmonary arterial endothelial cells

2002 • 59 citations

THE INITIATION AND GROWTH OF TUMORS

2009 • 57 citations

Calorie restriction protects against age‐related rat aorta sclerosis

2005 • 56 citations

Caloric Restriction and Experimental Carcinogenesis

2002 • 54 citations

Ascorbate Stabilization Is Stimulated in ρ°HL-60 Cells by CoQ10Increase at the Plasma Membrane

1997 • 54 citations

Caloric Restriction and Cardiovascular Aging in Cynomolgus Monkeys (Macaca fascicularis): Metabolic, Physiologic, and Atherosclerotic Measures From a 4-Year Intervention Trial

2004 • 50 citations

Caloric Restriction Mimetics

2007 • 45 citations

Mouse liver plasma membrane redox system activity is altered by aging and modulated by calorie restriction

2005 • 42 citations

Coenzyme Q content depends upon oxidative stress and dietary fat unsaturation

1997 • 42 citations

Effects of Dietary Restriction on the Expression of Insulin-Signaling-Related Genes in Long-Lived Mutant Mice

2006 • 39 citations

Dietary Restriction Downregulates Free Radical and Lipid Peroxide Production: Plausible Mechanism for Elongation of Life Span.

2002 • 38 citations

Caloric restriction lowers plasma lipoprotein (a) in male but not female rhesus monkeys

2001 • 31 citations

Cytosolic NAD(P)H Regulation of Redox Signaling and Vascular Oxygen Sensing

2007 • 30 citations

Food Restriction Attenuates Age-Related Increase in the Sensitivity of Endothelial Cells to Oxidized Lipids

2004 • 27 citations

Influence of pulmonary arterial endothelial cells on quinone redox status: effect of hyperoxia-induced NAD(P)H:quinone oxidoreductase 1

2005 • 24 citations

Role of mitochondrial electron transport complex I in coenzyme Q₁reduction by intact pulmonary arterial endothelial cells and the effect of hyperoxia

2007 • 23 citations

Inhibition of neutral Mg 2+ -dependent sphingomyelinase by ubiquinol-mediated plasma membrane electron transport

2003 • 18 citations

The Age Dynamics of Monoamine Oxidase Activity and Levels of Lipid Peroxidation Products in the Human Brain

2004 • 18 citations

Antioxidant response induced by serum withdrawal protects HL‐60 cells against inhibition of NAD(P)H:quinone oxidoreductase 1

2003 • 5 citations