Cardiac-specific overexpression of insulin-like growth factor 1 attenuates aging-associated cardiac diastolic contractile dysfunction and protein damage

Cardiac excitation–contraction coupling

2002 • 4,343 citations

Improved Arterial Compliance by a Novel Advanced Glycation End-Product Crosslink Breaker

2001 • 710 citations

IGF-1 Overexpression Inhibits the Development of Diabetic Cardiomyopathy and Angiotensin II–Mediated Oxidative Stress

2001 • 377 citations

Insulin-like Growth Factor I as aÈCardiac Hormone: Physiological and Pathophysiological Implications in Heart Disease

1999 • 296 citations

Overexpression of insulin-like growth factor-1 in the heart is coupled with myocyte proliferation in transgenic mice.

1996 • 293 citations

Human aging: Changes in structure and function

1987 • 258 citations

Cardiac myocyte calcium transport in phospholamban knockout mouse: relaxation and endogenous CaMKII effects

1998 • 223 citations

Cardiac contractile dysfunction in Lep/Lep obesity is accompanied by NADPH oxidase activation, oxidative modification of sarco(endo)plasmic reticulum Ca2+-ATPase and myosin heavy chain isozyme switch

2006 • 179 citations

Serum Levels of Insulin-Like Growth Factor-I (IGF-I) and IGF-Binding Protein-3 in Healthy Centenarians: Relationship with Plasma Leptin and Lipid Concentrations, Insulin Action, and Cognitive Function

1997 • 175 citations

Cardiovascular Aging Research: The Next Horizons

1999 • 143 citations

Sarcoplasmic reticulum Ca2+ uptake and thapsigargin sensitivity in permeabilized rabbit and rat ventricular myocytes.

1993 • 121 citations

Overexpression of Aldehyde Dehydrogenase-2 (ALDH2) Transgene Prevents Acetaldehyde-induced Cell Injury in Human Umbilical Vein Endothelial Cells

2004 • 118 citations

Aging induces cardiac diastolic dysfunction, oxidative stress, accumulation of advanced glycation endproducts and protein modification

2005 • 117 citations

CARDIOVASCULAR AGING IN HEALTH

2000 • 115 citations

Left Ventricular Diastolic Filling Performance in Older Male Athletes

1995 • 98 citations

Overexpression of alcohol dehydrogenase exacerbates ethanol-induced contractile defect in cardiac myocytes

2002 • 68 citations

Transgenic overexpression of insulin-like growth factor I prevents streptozotocin-induced cardiac contractile dysfunction and beta-adrenergic response in ventricular myocytes

2004 • 58 citations

The Presence of Lys27 Instead of Asn27 in Human Phospholamban Promotes Sarcoplasmic Reticulum Ca ²⁺ -ATPase Superinhibition and Cardiac Remodeling

2006 • 39 citations

Inhibition of PI-3 kinase/Akt/mTOR, but not calcineurin signaling, reverses insulin-like growth factor I-induced protection against glucose toxicity in cardiomyocyte contractile function

2005 • 34 citations

Attenuated cardiac contractile responsiveness to insulin-like growth factor I in ventricular myocytes from biobreeding spontaneous diabetic rats

2000 • 32 citations

The growth hormone and insulin-like growth factor 1 axis in heart failure.

2000 • 27 citations

Phosphorylation-status of phospholamban and calsequestrin modifies their affinity towards commonly used antibodies

2004 • 10 citations

Growth hormone and cardiac function.

2000 • 9 citations