Ceramide-dependent Caspase 3 Activation is Prevented by Coenzyme Q from Plasma Membrane in Serum-deprived Cells

A RAPID METHOD OF TOTAL LIPID EXTRACTION AND PURIFICATION

1959 • 47,127 citations

Bcl-2 functions in an antioxidant pathway to prevent apoptosis

1993 • 3,465 citations

Social controls on cell survival and cell death

1992 • 2,641 citations

Programmed Cell Death Induced by Ceramide

1993 • 1,779 citations

Bcl-2 inhibition of neural death: decreased generation of reactive oxygen species

1993 • 1,692 citations

Functions of Ceramide in Coordinating Cellular Responses to Stress

1996 • 1,620 citations

Programmed Cell Death and the Control of Cell Survival: Lessons from the Nervous System

1993 • 1,470 citations

The sphingomyelin cycle and the second messenger function of ceramide.

1994 • 1,255 citations

Superoxide dismutase delays neuronal apoptosis: A role for reactive oxygen species in programmed neuronal death

1995 • 744 citations

The Central Executioner of Apoptosis: Multiple Connections between Protease Activation and Mitochondria in Fas/APO-1/CD95- and Ceramide-induced Apoptosis

1997 • 625 citations

Identification of sphingomyelin turnover as an effector mechanism for the action of tumor necrosis factor alpha and gamma-interferon. Specific role in cell differentiation.

1991 • 621 citations

Cell-free apoptosis in Xenopus egg extracts: Inhibition by Bcl-2 and requirement for an organelle fraction enriched in mitochondria

1994 • 577 citations

Role for Ceramide in Cell Cycle Arrest

1995 • 488 citations

Induction of apoptotic DNA damage and cell death by activation of the sphingomyelin pathway.

1994 • 459 citations

Constitutive expression of the machinery for programmed cell death.

1996 • 386 citations

Inhibitors of oxidative stress mimic the ability of follicle-stimulating hormone to suppress apoptosis in cultured rat ovarian follicles.

1995 • 334 citations

Inhibition of the Neutral Magnesium-dependent Sphingomyelinase by Glutathione

1997 • 306 citations

Cell-free reconstitution of Fas-, UV radiation- and ceramide-induced apoptosis.

1995 • 243 citations

prICE: a downstream target for ceramide-induced apoptosis and for the inhibitory action of Bcl-2

1996 • 203 citations

Bcl‐2 Protects Isolated Plasma and Mitochondrial Membranes Against Lipid Peroxidation Induced by Hydrogen Peroxide and Amyloid β‐Peptide

1998 • 188 citations

Selective induction of apoptosis by capsaicin in transformed cells: the role of reactive oxygen species and calcium

1999 • 165 citations

Phospholipase A2 Is Necessary for Tumor Necrosis Factor α-induced Ceramide Generation in L929 Cells

1997 • 161 citations

Ceramide induces apoptosis via CPP32 activation

1996 • 133 citations

Vitamin E and selenium deficiency induces expression of the ubiquinone‐dependent antioxidant system at the plasma membrane

1998 • 130 citations

Involvement of phospholipase A2 activation in tumour cell killing by tumour necrosis factor.

1988 • 124 citations

Intracellular redox changes during apoptosis.

1996 • 110 citations

Ascorbate and α-Tocopherol Prevent Apoptosis Induced by Serum Removal Independent of Bcl-2

1997 • 89 citations

Induction of apoptosis by vanilloid compounds does not require de novo gene transcription and activator protein 1 activity.

1998 • 81 citations

Plasma membrane ubiquinone controls ceramide production and prevents cell death induced by serum withdrawal.

1997 • 78 citations

Enhanced Interfacial Catalysis and Hydrolytic Specificity of Phospholipase A2 toward Peroxidized Phosphatidylcholine Vesicles

1993 • 66 citations

Effectors of the mammalian plasma membrane NADH-oxidoreductase system. Short-chain ubiquinone analogues as potent stimulators

1996 • 47 citations

Neutral magnesium-dependent sphingomyelinase from liver plasma membrane: purification and inhibition by ubiquinol.

2001 • 32 citations

Comparison of growth stimulation of HeLa cells, HL-60 cells, and mouse fibroblasts by coenzyme Q10

1995 • 22 citations