Apoptosis and proliferation in nongenotoxic carcinogenesis: species differences and role of PPARα

Activation of a member of the steroid hormone receptor superfamily by peroxisome proliferators

1990 • 3,462 citations

Analysis of any point mutation in DNA. The amplification refractory mutation system (ARMS)

1989 • 2,480 citations

Targeted Disruption of the α Isoform of the Peroxisome Proliferator-Activated Receptor Gene in Mice Results in Abolishment of the Pleiotropic Effects of Peroxisome Proliferators

1995 • 1,626 citations

Role of the peroxisome proliferator-activated receptor (PPAR) in mediating the effects of fibrates and fatty acids on gene expression

1996 • 1,201 citations

Initiation of liver growth by tumor necrosis factor: Deficient liver regeneration in mice lacking type I tumor necrosis factor receptor

1997 • 937 citations

Biologically active products of stimulated liver macrophages (Kupffer cells)

1990 • 926 citations

The mouse peroxisome proliferator activated receptor recognizes a response element in the 5′ flanking sequence of the rat acyl CoA oxidase gene.

1992 • 903 citations

Induction of apoptosis in cultured hepatocytes and in regressing liver by transforming growth factor beta 1.

1992 • 675 citations

cDNA cloning, chromosomal mapping, and functional characterization of the human peroxisome proliferator activated receptor

1993 • 523 citations

Peroxisome proliferator activated receptor-alpha expression in human liver.

1998 • 449 citations

Peroxisome Proliferator Activated Receptor-α Expression in Human Liver

1998 • 397 citations

Mechanistically-based Human Hazard Assessment of Peroxisome Proliferator-induced Hepatocarcinogenesis

1994 • 318 citations

Hepatocarcinogenic Potential of Di(2-Ethylhexyl)phthalate in Rodents and its Implications on Human Risk

1996 • 309 citations

Human and rat peroxisome proliferator activated receptors (PPARs) demonstrate similar tissue distribution but different responsiveness to PPAR activators

1994 • 273 citations

Do Peroxisome Proliferating Compounds Pose a Hepatocarcinogenic Hazard to Humans?

1998 • 248 citations

Hepatocyte apoptosis: Is transforming growth factor-B1 the kiss of death? Oberhammer FA, Pavelka M, Sharma S, Tietenbacher R, Purchio AF, Bursch W, Schulte-Hermann R. Induction of apoptosis in cultured hepatocytes and in regressing liver by transforming growth factor β1. Proc Natl Acad Sci USA 1992;89:5408–5412

1993 • 233 citations

Deficient liver regeneration after carbon tetrachloride injury in mice lacking type 1 but not type 2 tumor necrosis factor receptor.

1998 • 211 citations

Suppression of liver cell apoptosis in vitro by the non-genotoxic hepatocarcinogen and peroxisome proliferator nafenopin.

1994 • 186 citations

Peroxisome proliferation and nongenotoxic carcinogenesis: Commentary on a symposium*1

1991 • 185 citations

Recent Progress in the Tumor Necrosis Factor-α Field

1996 • 151 citations

Evidence for the suppression of apoptosis by the peroxisome proliferator activated receptor alpha (PPAR alpha)

1998 • 141 citations

The peroxisome proliferator (PP) response element upstream of the human acyl CoA oxidase gene is inactive among a sample human population: significance for species differences in response to PPs

1999 • 103 citations

A peroxisome proliferator-activated receptor-alpha (PPARα) cDNA cloned from guinea-pig liver encodes a protein with similar properties to the mouse PPARα: implications for species differences in responses to peroxisome proliferators

1998 • 90 citations

Kupffer cell oxidant production is central to the mechanism of peroxisome proliferators

1999 • 88 citations

Tumour necrosis factor alpha (TNF alpha) suppresses apoptosis and induces DNA synthesis in rodent hepatocytes: a mediator of the hepatocarcinogenicity of peroxisome proliferators?

1997 • 87 citations

Perturbation of the Mitosis/Apoptosis Balance: A Fundamental Mechanism in Toxicology,

1997 • 86 citations

Regulation of apoptosis in mouse hepatocytes and alteration of apoptosis by nongenotoxic carcinogens.

1998 • 82 citations

Regulation of Gene Expression by Fatty Acids and Fibric Acid Derivatives: An Integrative Role for Peroxisome Prolif erator Activated Receptors

1992 • 76 citations

Peroxisomes : biology and role in toxicology and disease

1996 • 70 citations

Molecular basis of non-responsiveness to peroxisome proliferators: the guinea-pig PPARα is functional and mediates peroxisome proliferator-induced hypolipidaemia

1998 • 68 citations

Effect of Rodent Hepatocarcinogenic Peroxisome Proliferators on Fatty Acyl-CoA Oxidase, DNA Synthesis, and Apoptosis in Cultured Human and Rat Hepatocytes

1998 • 67 citations

The Role of Peroxisome Proliferator Activated Receptor α in Peroxisome Proliferation, Physiological Homeostasis, and Chemical Carcinogenesis

1997 • 59 citations

Cytokines in non-genotoxic hepatocarcinogenesis

1999 • 59 citations

Hepatocyte death in hepatocarcinogenesis

1998 • 52 citations

Adaptive Liver Growth Induced by Xenobiotic Compounds: Its Nature and Mechanism

1979 • 49 citations

Perturbation of rodent hepatocyte growth control by nongenotoxic hepatocarcinogens: mechanisms and lack of relevance for human health (review).

1998 • 47 citations

Comparative Toxicology of Hypolipidaemic Fibrates

1996 • 29 citations

Divide and rule

1996 • 23 citations

Evaluation of the reproductive toxicology of 2,4,6-trichlorophenol in male and female rats

1986 • 22 citations

Amino Acid Residues in both the DNA-Binding and Ligand-Binding Domains Influence Transcriptional Activity of the Human Peroxisome Proliferator-Activated Receptor Alpha

1997 • 20 citations

An in vitro model of rodent nongenotoxic hepatocarcinogenesis

1992 • 12 citations

NON-GENOTOXIC HEPATOCARCINOGENS STIMULATE DNA SYNTHESIS AND SUPPRESS APOPTOSIS BUT IN DIFFERENT HEPATOCYTE POPULATIONS

1996 • 3 citations

Comparative toxicology of hypolipidaemic fibrates

1997 • 1 citations