Functional Evidence for Retinoid X Receptor (RXR) as a Nonsilent Partner in the Thyroid Hormone Receptor/RXR Heterodimer

The nuclear receptor superfamily: The second decade

1995 • 6,929 citations

Molecular basis of agonism and antagonism in the oestrogen receptor

1997 • 3,285 citations

The RXR heterodimers and orphan receptors

1995 • 3,168 citations

The Structural Basis of Estrogen Receptor/Coactivator Recognition and the Antagonism of This Interaction by Tamoxifen

1998 • 2,622 citations

The coregulator exchange in transcriptional functions of nuclear receptors

2000 • 2,219 citations

Ligand-independent repression by the thyroid hormone receptor mediated by a nuclear receptor co-repressor

1995 • 2,059 citations

Ligand binding and co-activator assembly of the peroxisome proliferator-activated receptor-γ

1998 • 1,902 citations

9-cis retinoic acid is a high affinity ligand for the retinoid X receptor

1992 • 1,790 citations

Nuclear Receptor Coregulators: Cellular and Molecular Biology*

1999 • 1,783 citations

Convergence of 9-cis retinoic acid and peroxisome proliferator signalling pathways through heterodimer formation of their receptors

1992 • 1,751 citations

A transcriptional co-repressor that interacts with nuclear hormone receptors

1995 • 1,744 citations

Direct repeats as selective response elements for the thyroid hormone, retinoic acid, and vitamin D3 receptors

1991 • 1,725 citations

Nuclear Hormone Receptors and Gene Expression

2001 • 1,538 citations

Regulation of Absorption and ABC1-Mediated Efflux of Cholesterol by RXR Heterodimers

2000 • 1,285 citations

9-Cis retinoic acid stereoisomer binds and activates the nuclear receptor RXRα

1992 • 1,252 citations

Crystal structure of the RAR-γ ligand-binding domain bound to all-trans retinoic acid

1995 • 1,085 citations

Nonsteroid nuclear receptors: What Are genetic studies telling us about their role in real life?

1995 • 1,011 citations

A structural role for hormone in the thyroid hormone receptor

1995 • 938 citations

Structure and specificity of nuclear receptor–coactivator interactions

1998 • 922 citations

The CoRNR motif controls the recruitment of corepressors by nuclear hormone receptors

1999 • 637 citations

Unique response pathways are established by allosteric interactions among nuclear hormone receptors

1995 • 629 citations

Sensitization of diabetic and obese mice to insulin by retinoid X receptor agonists

1997 • 614 citations

Molecular determinants of nuclear receptor-corepressor interaction

1999 • 516 citations

Modular structure of a chicken lysozyme silencer: Involvement of an unusual thyroid hormone receptor binding site

1990 • 487 citations

Regulation of retinoid signalling by receptor polarity and allosteric control of ligand binding

1994 • 432 citations

Genetic evidence that the retinoid signal is transduced by heterodimeric RXR/RAR functional units during mouse development

1997 • 428 citations

Mechanism of corepressor binding and release from nuclear hormone receptors

1999 • 414 citations

Orphan nuclear receptors—new ligands and new possibilities: Figure 1.

1998 • 301 citations

Co-regulator recruitment and the mechanism of retinoic acid receptor synergy

2002 • 300 citations

Regulation of the transcriptional coactivator PGC-1 via MAPK-sensitive interaction with a repressor

2001 • 267 citations

SMRT isoforms mediate repression and anti-repression of nuclear receptor heterodimers.

1996 • 244 citations

Hepatocyte-Specific Mutation Establishes Retinoid X Receptor α as a Heterodimeric Integrator of Multiple Physiological Processes in the Liver

2000 • 226 citations

Proteasomal regulation of nuclear receptor corepressor-mediated repression

1998 • 225 citations

Half-site spacing and orientation determines whether thyroid hormone and retinoic acid receptors and related factors bind to DNA response elements as monomers, homodimers, or heterodimers.

1992 • 216 citations

Two distinct actions of retinoid-receptor ligands

1996 • 200 citations

The SMRT Corepressor Is Regulated by a MEK-1 Kinase Pathway: Inhibition of Corepressor Function Is Associated with SMRT Phosphorylation and Nuclear Export

2000 • 187 citations

Synergistic Activation of Retinoic Acid (RA)-Responsive Genes and Induction of Embryonal Carcinoma Cell Differentiation by an RA Receptor α (RARα)-, RARβ-, or RARγ-Selective Ligand in Combination with a Retinoid X Receptor-Specific Ligand

1995 • 180 citations

Vitamin A deficiency and mutations of RXRα, RXRβ and RARα lead to early differentiation of embryonic ventricular cardiomyocytes

1997 • 171 citations

Factor recruitment and TIF2/GRIP1 corepressor activity at a collagenase-3 response element that mediates regulation by phorbol esters and hormones

2001 • 168 citations

Retinoid X Receptor (RXR) within the RXR-Retinoic Acid Receptor Heterodimer Binds Its Ligand and Enhances Retinoid-Dependent Gene Expression

1997 • 167 citations

Activation of specific RXR heterodimers by an antagonist of RXR homodimers

1996 • 164 citations

The Conserved Ninth C-Terminal Heptad in Thyroid Hormone and Retinoic Acid Receptors Mediates Diverse Responses by Affecting Heterodimer but Not Homodimer Formation

1993 • 132 citations

The phantom ligand effect: allosteric control of transcription by the retinoid X receptor.

1997 • 128 citations

Functional Evidence for Ligand-Dependent Dissociation of Thyroid Hormone and Retinoic Acid Receptors from an Inhibitory Cellular Factor

1994 • 116 citations

Characterization of Receptor Interaction and Transcriptional Repression by the Corepressor SMRT

1997 • 112 citations

Dynamic Stabilization of Nuclear Receptor Ligand Binding Domains by Hormone or Corepressor Binding

2000 • 108 citations

The Ligand-Binding Domains of the Thyroid Hormone/Retinoid Receptor Gene Subfamily Function in Vivo To Mediate Heterodimerization, Gene Silencing, and Transactivation

1995 • 82 citations

Differential Recognition of Liganded and Unliganded Thyroid Hormone Receptor by Retinoid X Receptor Regulates Transcriptional Repression

1997 • 70 citations

NRIF3 Is a Novel Coactivator Mediating Functional Specificity of Nuclear Hormone Receptors

1999 • 66 citations

Identification of a domain required for oncogenic activity and transcriptional suppression by v-erbA and thyroid-hormone receptor alpha.

1993 • 54 citations

Individual Subunits of Heterodimers Comprised of Retinoic Acid and Retinoid X Receptors Interact with Their Ligands Independently

1996 • 52 citations

pEXPRESS: A family of expression vectors containing a single transcription unit active in prokaryotes, eukaryotes and in vitro

1991 • 49 citations

Domain Structure of the NRIF3 Family of Coregulators Suggests Potential Dual Roles in Transcriptional Regulation

2001 • 30 citations

The effects of P-box substitutions in thyroid hormone receptor on DNA binding specificity.

1994 • 30 citations