Peroxisome Proliferator-activated Receptor α-Isoform Deficiency Leads to Progressive Dyslipidemia with Sexually Dimorphic Obesity and Steatosis

A RAPID METHOD OF TOTAL LIPID EXTRACTION AND PURIFICATION

1959 • 47,127 citations

A RAPID METHOD OF TOTAL LIPID EXTRACTION AND PURIFICATION

1959 • 21,307 citations

Positional cloning of the mouse obese gene and its human homologue

1994 • 12,975 citations

Stimulation of adipogenesis in fibroblasts by PPARγ2, a lipid-activated transcription factor

1994 • 3,477 citations

Targeted Disruption of the Melanocortin-4 Receptor Results in Obesity in Mice

1997 • 2,992 citations

Congenital leptin deficiency is associated with severe early-onset obesity in humans

1997 • 2,900 citations

Abnormal splicing of the leptin receptor in diabetic mice

1996 • 2,361 citations

A mutation in the human leptin receptor gene causes obesity and pituitary dysfunction

1998 • 2,333 citations

AdipoQ Is a Novel Adipose-specific Gene Dysregulated in Obesity

1996 • 2,229 citations

mPPAR gamma 2: tissue-specific regulator of an adipocyte enhancer.

1994 • 2,176 citations

Fatty acids and eicosanoids regulate gene expression through direct interactions with peroxisome proliferator-activated receptors α and γ

1997 • 2,105 citations

Body Weight and Mortality among Women

1995 • 2,018 citations

Oxidized LDL Regulates Macrophage Gene Expression through Ligand Activation of PPARγ

1998 • 1,819 citations

PPARγ Promotes Monocyte/Macrophage Differentiation and Uptake of Oxidized LDL

1998 • 1,771 citations

An oxysterol signalling pathway mediated by the nuclear receptor LXRα

1996 • 1,678 citations

Targeted Disruption of the α Isoform of the Peroxisome Proliferator-Activated Receptor Gene in Mice Results in Abolishment of the Pleiotropic Effects of Peroxisome Proliferators

1995 • 1,626 citations

The PPARα–leukotriene B4 pathway to inflammation control

1996 • 1,328 citations

Adipogenesis and Obesity: Rounding Out the Big Picture

1996 • 1,268 citations

Role of the peroxisome proliferator-activated receptor (PPAR) in mediating the effects of fibrates and fatty acids on gene expression

1996 • 1,201 citations

Fatty Acids, Eicosanoids, and Hypolipidemic Agents Identified as Ligands of Peroxisome Proliferator-Activated Receptors by Coactivator-Dependent Receptor Ligand Assay

1997 • 1,158 citations

Obesity and impaired prohormone processing associated with mutations in the human prohormone convertase 1 gene

1997 • 1,125 citations

Requirement of STAT5b for sexual dimorphism of body growth rates and liver gene expression

1997 • 989 citations

Molecular characterization of the mouse agouti locus

1992 • 791 citations

Differential Activation of Peroxisome Proliferator-activated Receptors by Eicosanoids

1995 • 700 citations

Regulation of PPAR gamma gene expression by nutrition and obesity in rodents.

1996 • 654 citations

Transdifferentiation of myoblasts by the adipogenic transcription factors PPAR gamma and C/EBP alpha.

1995 • 651 citations

The peroxisome proliferator-activated receptor regulates mitochondrial fatty acid oxidative enzyme gene expression.

1994 • 558 citations

Induction of ob Gene Expression by Corticosteroids Is Accompanied by Body Weight Loss and Reduced Food Intake

1995 • 485 citations

Peroxisome proliferator activated receptor-alpha expression in human liver.

1998 • 449 citations

Alterations in Lipoprotein Metabolism in Peroxisome Proliferator-activated Receptor α-deficient Mice

1997 • 419 citations

Genetically lean mice result from targeted disruption of the RIIβ subunit of protein kinase A

1996 • 406 citations

Peroxisome Proliferator Activated Receptor-α Expression in Human Liver

1998 • 397 citations

Increased hepatocyte CYP2E1 expression in a rat nutritional model of hepatic steatosis with inflammation

1996 • 391 citations

Identification and Characterization of the Mouse Obesity Gene tubby: A Member of a Novel Gene Family

1996 • 366 citations

Adipocyte P2 gene: developmental expression and homology of 5'-flanking sequences among fat cell-specific genes.

1986 • 334 citations

Transcription regulation of peroxisomal fatty acyl-CoA oxidase and enoyl-CoA hydratase/3-hydroxyacyl-CoA dehydrogenase in rat liver by peroxisome proliferators.

1986 • 328 citations

Body Weight and Mortality

2009 • 293 citations

Polyunsaturated Fatty Acid Suppression of Hepatic Fatty Acid Synthase and S14 Gene Expression Does Not Require Peroxisome Proliferator-activated Receptor α

1997 • 266 citations

Hepatocellular and Hepatic Peroxisomal Alterations in Mice with a Disrupted Peroxisomal Fatty Acyl-coenzyme A Oxidase Gene

1996 • 246 citations

High Fatty Acid Content in Rabbit Serum Is Responsible for the Differentiation of Osteoblasts Into Adipocyte-like Cells

1998 • 210 citations

Fenofibrate

1990 • 181 citations

Centrilobular expression of ethanol-inducible cytochrome P-450 (IIE1) in rat liver

1988 • 178 citations

Unique requirements for retinoid-dependent transcriptional activation by the orphan receptor LXR.

1997 • 166 citations

The peroxisome proliferator activated receptor regulates malic enzyme gene expression.

1994 • 157 citations

Hepatic mitochondrial DNA deletion in alcoholics: Association with microvesicular steatosis

1995 • 148 citations

Rat peroxisomal 3-ketoacyl-CoA thiolase gene. Occurrence of two closely related but differentially regulated genes.

1990 • 131 citations

Long-term correction of obesity and diabetes in genetically obese mice by a single intramuscular injection of recombinant adeno-associated virus encoding mouse leptin

1997 • 124 citations

Peroxisome Proliferator–induced Pleiotropic Responses: Pursuit of a Phenomenon^a

1996 • 111 citations

Regulation of Triglyceride Metabolism by PPARs : Fibrates and Thiazolidinediones have Distinct Effects

1996 • 109 citations

Reye's syndrome: Current concepts

1987 • 99 citations

Recent update on the PPARα-null mouse

1997 • 97 citations

RXR Agonists Activate PPARα-Inducible Genes, Lower Triglycerides, and Raise HDL Levels In Vivo

1998 • 87 citations

Attenuation of the Polypeptide 7B2, Prohormone Convertase PC2, and Vasopressin in the Hypothalamus of Some Prader-Willi Patients: Indications for a Processing Defect

1998 • 66 citations

Studies in rat liver perfusion for optimal harvest of hepatocytes

1990 • 59 citations

Absence of Linkage of Obesity and Energy Metabolism to Markers Flanking Homologues of Rodent Obesity Genes in Pima Indians

1996 • 56 citations

Transcriptional induction of the fatty acid binding protein gene in mouse liver by bezafibrate

1993 • 47 citations

A single amino acid change in the mouse peroxisome proliferator-activated receptor alpha alters transcriptional responses to peroxisome proliferators.

1995 • 46 citations

Isolation and Characterization of the Gene for Mouse Hormone-Sensitive Lipase

1994 • 45 citations

Coordinate induction of acyl-CoA binding protein, fatty acid binding protein and peroxisomal β-oxidation by peroxisome proliferators

1993 • 41 citations

The fibrates in clinical practice: Focus on micronised fenofibrate

1994 • 34 citations

The genetics of obesity

1997 • 32 citations

The causes of obesity: advances in molecular biology but stagnation on the genetic front

1996 • 31 citations

Zonation of cytochrome P450 enzyme expression in rat liver

1996 • 24 citations

Targeted Disruption of the Peroxisomal Fatty Acyl‐CoA Oxidase Gene: Generation of a Mouse Model of Pseudoneonatal Adrenoleukodystrophy^a

1996 • 23 citations

Comparative effects of gemfibrozil and clofibrate in type III hyperlipoproteinemia

1994 • 16 citations

Effects of initial BMI and on-treatment weight change on the lipid-lowering efficacy of fibrates

1997 • 12 citations

[18] High-performance liquid chromatography of apolipoproteins

1986 • 11 citations

Transgenic and knockout rodents: Novel insights into mechanisms of body weight regulation

1997 • 6 citations