Does Rap1 deserve a bad Rap?

Epac is a Rap1 guanine-nucleotide-exchange factor directly activated by cyclic AMP

1998 • 1,931 citations

A Family of cAMP-Binding Proteins That Directly Activate Rap1

1998 • 1,351 citations

Switching of the coupling of the β2-adrenergic receptor to different G proteins by protein kinase A

1997 • 1,247 citations

cAMP Activates MAP Kinase and Elk-1 through a B-Raf- and Rap1-Dependent Pathway

1997 • 1,047 citations

Crosstalk between cAMP and MAP kinase signaling in the regulation of cell proliferation

2002 • 881 citations

Rap1 mediates sustained MAP kinase activation induced by nerve growth factor

1998 • 868 citations

Ras and Rap Control AMPA Receptor Trafficking during Synaptic Plasticity

2002 • 756 citations

A novel Epac-specific cAMP analogue demonstrates independent regulation of Rap1 and ERK

2002 • 687 citations

Rap1 signalling: adhering to new models

2001 • 601 citations

Maintenance of Human T Cell Anergy: Blocking of IL-2 Gene Transcription by Activated Rap1

1997 • 420 citations

Regulation of Dendritic Spine Morphology by SPAR, a PSD-95-Associated RapGAP

2001 • 383 citations

Identification of the Mechanisms Regulating the Differential Activation of the MAPK Cascade by Epidermal Growth Factor and Nerve Growth Factor in PC12 Cells

2001 • 371 citations

A Rap guanine nucleotide exchange factor enriched highly in the basal ganglia

1998 • 360 citations

Ras mediates the cAMP-dependent activation of extracellular signal-regulated kinases (ERKs) in melanocytes

2000 • 323 citations

Epac-selective cAMP Analog 8-pCPT-2′-O-Me-cAMP as a Stimulus for Ca2+-induced Ca2+ Release and Exocytosis in Pancreatic β-Cells

2003 • 292 citations

Rap1A positively regulates T cells via integrin activation rather than inhibiting lymphocyte signaling

2002 • 276 citations

Activation and Induction of NUR77/NURR1 in Corticotrophs by CRH/cAMP: Involvement of Calcium, Protein Kinase A, and MAPK Pathways

2002 • 264 citations

Cyclic AMP induces integrin-mediated cell adhesion through Epac and Rap1 upon stimulation of the β2-adrenergic receptor

2003 • 264 citations

Adenosine receptors: G protein-mediated signalling and the role of accessory proteins

2002 • 260 citations

The Endocannabinoid Anandamide Inhibits Neuronal Progenitor Cell Differentiation through Attenuation of the Rap1/B-Raf/ERK Pathway

2002 • 248 citations

PKA Phosphorylation of Src Mediates cAMP's Inhibition of Cell Growth via Rap1

2002 • 245 citations

Nerve Growth Factor Activates Persistent Rap1 Signaling in Endosomes

2001 • 242 citations

Role of Phosphoinositide 3-Kinase and Endocytosis in Nerve Growth Factor-Induced Extracellular Signal-Regulated Kinase Activation via Ras and Rap1

2000 • 239 citations

Activation of the ERK/MAPK pathway by an isoform of rap1GAP associated with Gαi

1999 • 227 citations

Differential Effects of cAMP in Neurons and Astrocytes

1999 • 222 citations

Cellular functions of the Rap1 GTP-binding protein: a pattern emerges

2002 • 211 citations

The role of Rap1 in integrin-mediated cell adhesion

2003 • 208 citations

Ras and relatives—job sharing and networking keep an old family together

2002 • 185 citations

Cell Cycle-dependent Subcellular Localization of Exchange Factor Directly Activated by cAMP

2002 • 175 citations

β2-Adrenergic Receptor Activates Extracellular Signal-regulated Kinases (ERKs) via the Small G Protein Rap1 and the Serine/Threonine Kinase B-Raf

2000 • 174 citations

Distinct Roles of the Adaptor Protein Shc and Focal Adhesion Kinase in Integrin Signaling to ERK

2000 • 171 citations

Neuronal Calcium Activates a Rap1 and B-Raf Signaling Pathway via the Cyclic Adenosine Monophosphate-dependent Protein Kinase

2000 • 163 citations

cAMP-dependent Protein Kinase Induces cAMP-response Element-binding Protein Phosphorylation via an Intracellular Calcium Release/ERK-dependent Pathway in Striatal Neurons

2001 • 158 citations

Identification of Guanine Nucleotide Exchange Factors (GEFs) for the Rap1 GTPase

2000 • 156 citations

Cyclic AMP-Mediated Inhibition of Cell Growth Requires the Small G Protein Rap1

2001 • 155 citations

Role of the CDC25 Homology Domain of Phospholipase Cε in Amplification of Rap1-dependent Signaling

2001 • 141 citations

CalDAG-GEFIII Activation of Ras, R-Ras, and Rap1

2000 • 140 citations

Cyclic AMP-dependent Activation of Rap1b

1995 • 131 citations

Coordinated Regulation of Rap1 and Thyroid Differentiation by Cyclic AMP and Protein Kinase A

2001 • 130 citations

Characterization of RasGRP2, a Plasma Membrane-targeted, Dual Specificity Ras/Rap Exchange Factor

2000 • 130 citations

Protein Kinase A-independent Activation of ERK and H,K-ATPase by cAMP in Native Kidney Cells

2002 • 128 citations

Activation of Mitogen-activated Protein Kinase by the A2A-adenosine Receptor via a rap1-dependent and via a p21 -dependent Pathway

1999 • 121 citations

Rap1 is involved in cell stretching modulation of p38 but not ERK or JNK MAP kinase

2001 • 118 citations

New Signaling Pathway for Parathyroid Hormone and Cyclic AMP Action on Extracellular-regulated Kinase and Cell Proliferation in Bone Cells

2002 • 116 citations

Mechanism of the spatio-temporal regulation of Ras and Rap1

2003 • 111 citations

Ras Participates in the Activation of p38 MAPK by Interleukin-1 by Associating with IRAK, IRAK2, TRAF6, and TAK-1

2002 • 109 citations

Elevation of cyclic adenosine 3',5'-monophosphate potentiates activation of mitogen-activated protein kinase by growth factors in LNCaP prostate cancer cells.

1999 • 109 citations

Ras-dependent ERK Activation by the Human Gs-coupled Serotonin Receptors 5-HT4(b) and 5-HT7(a)

2003 • 109 citations

Identification and Characterization of RA-GEF-2, a Rap Guanine Nucleotide Exchange Factor That Serves as a Downstream Target of M-Ras

2001 • 105 citations

nRap GEP: A Novel Neural GDP/GTP Exchange Protein for Rap1 Small G Protein That Interacts with Synaptic Scaffolding Molecule (S-SCAM)

1999 • 105 citations

Cell Type-specific Regulation of B-Raf Kinase by cAMP and 14-3-3 Proteins

2000 • 101 citations

Analysis of R-Ras signalling pathways

2001 • 100 citations

Thrombopoietin-Mediated Sustained Activation of Extracellular Signal-Regulated Kinase in UT7-Mpl Cells Requires Both Ras–Raf-1- and Rap1–B-Raf-Dependent Pathways

2001 • 97 citations

Thyrotropin Activates Mitogen-Activated Protein Kinase Pathway in FRTL-5 by a cAMP-Dependent Protein Kinase A-Independent Mechanism

2001 • 93 citations

Stimulation of Endothelin B Receptors in Astrocytes Induces cAMP Response Element-Binding Protein Phosphorylation andc-fosExpression Via Multiple Mitogen-Activated Protein Kinase Signaling Pathways

2001 • 92 citations

Focal Adhesions Require Catalytic Activity of Src Family Kinases To Mediate Integrin-Matrix Adhesion

2002 • 87 citations

Analysis of the Gs/Mitogen-activated Protein Kinase Pathway in Mutant S49 Cells

1998 • 82 citations

CD28 and the Tyrosine Kinase Lck Stimulate Mitogen-Activated Protein Kinase Activity in T Cells via Inhibition of the Small G Protein Rap1

2000 • 81 citations

A CalDAG-GEFI/Rap1/B-Raf Cassette Couples M1Muscarinic Acetylcholine Receptors to the Activation of ERK1/2

2001 • 79 citations

MAP Kinase Stimulation by cAMP Does Not Require RAP1 but SRC Family Kinases

2002 • 76 citations

Requirement of Ras for the Activation of Mitogen-Activated Protein Kinase by Calcium Influx, cAMP, and Neurotrophin in Hippocampal Neurons

2001 • 75 citations

cAMP Inhibition of Akt Is Mediated by Activated and Phosphorylated Rap1b

2002 • 75 citations

Dynamic interaction of cAMP with the rap guanine-nucleotide exchange factor epac1

2001 • 70 citations

Activation of Gz Attenuates Rap1-mediated Differentiation of PC12 Cells

2002 • 68 citations

Gα and Gβγ Require Distinct Src-dependent Pathways to Activate Rap1 and Ras

2002 • 65 citations

RA-GEF-1, a Guanine Nucleotide Exchange Factor for Rap1, Is Activated by Translocation Induced by Association with Rap1·GTP and Enhances Rap1-dependent B-Raf Activation

2001 • 63 citations

cAMP inhibits the proliferation of retinal pigmented epithelial cells through the inhibition of ERK1/2 in a PKA-independent manner

2002 • 58 citations

Cyclic AMP-independent Involvement of Rap1/B-Raf in the Angiotensin II AT2 Receptor Signaling Pathway in NG108-15 Cells

2003 • 58 citations

Activation and Induction of NUR77/NURR1 in Corticotrophs by CRH/cAMP: Involvement of Calcium, Protein Kinase A, and MAPK Pathways

2002 • 56 citations

The Requirement of Specific Membrane Domains for Raf-1 Phosphorylation and Activation

2003 • 52 citations

High Glucose Stimulates Synthesis of Fibronectin via a Novel Protein Kinase C, Rap1b, and B-Raf Signaling Pathway

2002 • 52 citations

Regulation of Extracellular Signal-Regulated Kinase Cascades by α- and β-Isoforms of the Human Thromboxane A₂Receptor

2002 • 50 citations

c-Src Signaling Induced by the Adapters Sin and Cas Is Mediated by Rap1 GTPase

2000 • 49 citations

Suppression of Integrin Activation by Activated Ras or Raf Does Not Correlate with Bulk Activation of ERK MAP Kinase

2002 • 42 citations

The Association of CRKII with C3G Can be Regulated by Integrins and Defines a Novel Means to Regulate the Mitogen-activated Protein Kinases

2000 • 42 citations

Drosophila PDZ-GEF, a Guanine Nucleotide Exchange Factor for Rap1 GTPase, Reveals a Novel Upstream Regulatory Mechanism in the Mitogen-Activated Protein Kinase Signaling Pathway

2002 • 39 citations

Analysis of the Role of the Mitogen-Activated Protein Kinase in Mediating Cyclic-Adenosine 3′,5′-Monophosphate Effects on Prolactin Promoter Activity

2001 • 36 citations

Identification and characterization of RA-GEF-2, a Rap guanine nucleotide exchange factor that serves as a downstream target of M-Ras

2002 • 34 citations

Combinatorial Effect of T-Cell Receptor Ligation and CD45 Isoform Expression on the Signaling Contribution of the Small GTPases Ras and Rap1

2000 • 29 citations

Stromal inhibition of megakaryocytic differentiation is associated with blockade of sustained Rap1 activation

2003 • 27 citations

Rap1 reverses transcriptional repression of TGF‐β type II receptor by a mechanism involving AP‐1 in the human pancreatic cancer cell line, UK Pan‐1

2002 • 15 citations

A CalDAG-GEFI/Rap1/B-Raf cassette couples M1 muscarinic acetylcholine receptors to the activation of ERK1/2

2002 • 15 citations

Analysis of the Role of the Mitogen-Activated Protein Kinase in Mediating Cyclic-Adenosine 3',5'-Monophosphate Effects on Prolactin Promoter Activity

2001 • 13 citations