Identification and Characterization of RA-GEF-2, a Rap Guanine Nucleotide Exchange Factor That Serves as a Downstream Target of M-Ras

Signaling Through Scaffold, Anchoring, and Adaptor Proteins

1997 • 2,268 citations

Epac is a Rap1 guanine-nucleotide-exchange factor directly activated by cyclic AMP

1998 • 1,931 citations

pEF-BOS, a powerful mammalian expression vector

1990 • 1,641 citations

A Family of cAMP-Binding Proteins That Directly Activate Rap1

1998 • 1,351 citations

FUNCTION AND REGULATION OF RAS

1993 • 1,161 citations

cAMP Activates MAP Kinase and Elk-1 through a B-Raf- and Rap1-Dependent Pathway

1997 • 1,047 citations

Rap1 mediates sustained MAP kinase activation induced by nerve growth factor

1998 • 868 citations

Rap1 signalling: adhering to new models

2001 • 601 citations

[16] Isolation of subcellular organelles

1990 • 563 citations

Phospholipase Cepsilon: a novel Ras effector

2001 • 360 citations

A Rap guanine nucleotide exchange factor enriched highly in the basal ganglia

1998 • 360 citations

Identification of Rap1 as a Target for the Crk SH3 Domain-Binding Guanine Nucleotide-Releasing Factor C3G

1995 • 359 citations

All in the family? New insights and questions regarding interconnectivity of Ras, Rap1 and Ral

1998 • 337 citations

Regulation of a Novel Human Phospholipase C, PLCε, through Membrane Targeting by Ras

2001 • 318 citations

Signal transduction from multiple Ras effectors

1997 • 308 citations

Isolation of rat hepatocyte plasma membranes. I. Presence of the three major domains.

1983 • 306 citations

A Novel Bifunctional Phospholipase C That Is Regulated by Gα12 and Stimulates the Ras/Mitogen-activated Protein Kinase Pathway

2001 • 273 citations

Role of Phosphoinositide 3-Kinase and Endocytosis in Nerve Growth Factor-Induced Extracellular Signal-Regulated Kinase Activation via Ras and Rap1

2000 • 239 citations

A novel family ofras-binding domains

1996 • 207 citations

Cysteine-rich Region of Raf-1 Interacts with Activator Domain of Post-translationally Modified Ha-Ras

1995 • 157 citations

Identification of Guanine Nucleotide Exchange Factors (GEFs) for the Rap1 GTPase

2000 • 156 citations

Role of the CDC25 Homology Domain of Phospholipase Cε in Amplification of Rap1-dependent Signaling

2001 • 141 citations

The Effect of Posttranslational Modifications on the Interaction of Ras2 with Adenylyl Cyclase

1993 • 139 citations

The guanine nucleotide exchange factor CNrasGEF activates Ras in response to cAMP and cGMP

2000 • 135 citations

Association of the Ras-antagonistic Rap1/Krev-1 proteins with the Golgi complex.

1991 • 128 citations

PDZ-GEF1, a Guanine Nucleotide Exchange Factor Specific for Rap1 and Rap2

1999 • 126 citations

M-Ras/R-Ras3, a Transforming Ras Protein Regulated by Sos1, GRF1, and p120 Ras GTPase-activating Protein, Interacts with the Putative Ras Effector AF6

1999 • 116 citations

Co-localization of the TSC2 product tuberin with its target Rap1 in the Golgi apparatus.

1996 • 109 citations

nRap GEP: A Novel Neural GDP/GTP Exchange Protein for Rap1 Small G Protein That Interacts with Synaptic Scaffolding Molecule (S-SCAM)

1999 • 105 citations

Coassociation of Rap1A and Ha-Ras with Raf-1 N-terminal Region Interferes with Ras-dependent Activation of Raf-1

1997 • 100 citations

Identification and characterization of R-ras3: a novel member of the RAS gene family with a non-ubiquitous pattern of tissue distribution

1997 • 90 citations

Plasma membrane recruitment of RalGDS is critical for Ras-dependent Ral activation

1999 • 89 citations

RA-GEF, a Novel Rap1A Guanine Nucleotide Exchange Factor Containing a Ras/Rap1A-associating Domain, Is Conserved between Nematode and Humans

1999 • 87 citations

The Strength of Interaction at the Raf Cysteine-Rich Domain Is a Critical Determinant of Response of Raf to Ras Family Small GTPases

1999 • 84 citations

Association of Yeast Adenylyl Cyclase with Cyclase-Associated Protein CAP Forms a Second Ras-Binding Site Which Mediates Its Ras-Dependent Activation

2000 • 66 citations

RA-GEF-1, a Guanine Nucleotide Exchange Factor for Rap1, Is Activated by Translocation Induced by Association with Rap1·GTP and Enhances Rap1-dependent B-Raf Activation

2001 • 63 citations

Characterization of GFR, a novel guanine nucleotide exchange factor for Rap1

1999 • 43 citations