Analysis of R-Ras signalling pathways

Specificity of receptor tyrosine kinase signaling: Transient versus sustained extracellular signal-regulated kinase activation

1995 • 4,589 citations

Rho, Rac, and Cdc42 GTPases regulate the assembly of multimolecular focal complexes associated with actin stress fibers, lamellipodia, and filopodia

1995 • 4,387 citations

A synthetic inhibitor of the mitogen-activated protein kinase cascade.

1995 • 2,723 citations

Mitogen-activated protein kinase pathways

1997 • 2,513 citations

Isolation of monoclonal antibodies specific for human c-myc proto-oncogene product.

1985 • 2,456 citations

The protein kinase encoded by the Akt proto-oncogene is a target of the PDGF-activated phosphatidylinositol 3-kinase

1995 • 2,024 citations

Phosphatidylinositol-3-OH kinase direct target of Ras

1994 • 1,923 citations

An Essential Role for Rho, Rac, and Cdc42 GTPases in Cell Cycle Progression Through G ₁

1995 • 1,142 citations

Requirement for Ras in Raf activation is overcome by targeting Raf to the plasma membrane

1994 • 1,012 citations

Identification of Two Distinct Mechanisms of Phagocytosis Controlled by Different Rho GTPases

1998 • 993 citations

Activation of Raf as a Result of Recruitment to the Plasma Membrane

1994 • 979 citations

Ras1 and a putative guanine nucleotide exchange factor perform crucial steps in signaling by the sevenless protein tyrosine kinase

1991 • 869 citations

Monoclonal antibodies to the p21 products of the transforming gene of Harvey murine sarcoma virus and of the cellular ras gene family

1982 • 836 citations

Direct interaction of Ras and the amino-terminal region of Raf-1 in vitro

1993 • 730 citations

RasGRP, a Ras Guanyl Nucleotide- Releasing Protein with Calcium- and Diacylglycerol-Binding Motifs

1998 • 662 citations

Activation of extracellular signal-regulated kinase, ERK2, by p21ras oncoprotein.

1992 • 490 citations

A sensitive method for detection of calmodulin-dependent protein kinase II activity in sodium dodecyl sulfate-polyacrylamide gel

1989 • 466 citations

Integrin Activation by R-ras

1996 • 414 citations

Microinjection of the oncogene form of the human H-ras (t-24) protein results in rapid proliferation of quiescent cells

1984 • 401 citations

Transformation of NIH 3T3 cells by microinjection of Ha-ras p21 protein

1984 • 379 citations

Ral-GTPases mediate a distinct downstream signaling pathway from Ras that facilitates cellular transformation.

1996 • 335 citations

Phosphatidylinositol 3-kinase signals activate a selective subset of Rac/Rho-dependent effector pathways

1996 • 285 citations

Activated Ras interacts with the Ral guanine nucleotide dissociation stimulator.

1994 • 281 citations

Identification of the guanine nucleotide dissociation stimulator for Ral as a putative effector molecule of R-ras, H-ras, K-ras, and Rap.

1994 • 270 citations

ralGDS family members interact with the effector loop of ras p21.

1994 • 260 citations

The GTPase Rap1 controls functional activation of macrophage integrin αMβ2 by LPS and other inflammatory mediators

2000 • 259 citations

Molecular cloning of a GTPase activating protein specific for the Krev-1 protein p21rap1

1991 • 245 citations

A Role for the Ral Guanine Nucleotide Dissociation Stimulator in Mediating Ras-induced Transformation

1996 • 245 citations

R-Ras can activate the phosphoinositide 3-kinase but not the MAP kinase arm of the Ras effector pathways

1997 • 223 citations

Structure of the human and murine R-ras genes, novel genes closely related to ras proto-oncogenes

1987 • 216 citations

The effect of Mg2+ on the guanine nucleotide exchange rate of p21N-ras.

1986 • 203 citations

Ras and Rap1: Two Highly Related Small GTPases with Distinct Function

1999 • 175 citations

Characterization of a guanine nucleotide dissociation stimulator for a ras-related GTPase.

1993 • 174 citations

Stimulation of gene induction and cell growth by the Ras effector Rlf

1997 • 167 citations

Characterization of rhoGAP. A GTPase-activating protein for rho-related small GTPases.

1994 • 159 citations

R-Ras Signals through Specific Integrin α Cytoplasmic Domains to Promote Migration and Invasion of Breast Epithelial Cells

1999 • 156 citations

The mitogen-activated protein kinase cascade is activated by B-Raf in response to nerve growth factor through interaction with p21ras.

1994 • 141 citations

Thermodynamic and Kinetic Characterization of the Interaction between the Ras Binding Domain of AF6 and Members of the Ras Subfamily

1999 • 132 citations

Activation of R-Ras by Ras-Guanine Nucleotide-releasing Factor

1997 • 126 citations

RalGDS-like factor (Rlf) is a novel Ras and Rap 1A-associating protein.

1996 • 121 citations

Epidermal Growth Factor Regulates the Exchange Rate of Guanine Nucleotides on p21^ras in Fibroblasts

1993 • 117 citations

R-Ras induces malignant, but not morphologic, transformation of NIH3T3 cells.

1994 • 112 citations

Biochemical and biological properties of the human N-ras p21 protein.

1987 • 106 citations

Scrape-loading of Swiss 3T3 cells with ras protein rapidly activates protein kinase C in the absence of phosphoinositide hydrolysis.

1989 • 103 citations

The Small GTP-binding Protein R-Ras Can Influence Integrin Activation by Antagonizing a Ras/Raf-initiated Integrin Suppression Pathway

1999 • 93 citations

Different structural organization of Ras and Rho effector domains.

1993 • 83 citations

Oncogenic activation of human R-ras by point mutations analogous to those of prototype H-ras oncogenes.

1994 • 78 citations

Heterologous expression and characterization of the human R-ras gene product.

1987 • 73 citations

Activation of Phagocytic Cells' C3 Receptors for Phagocytosis

1985 • 73 citations

High-frequency disruption of the N-myc gene in embryonic stem and pre-B cell lines by homologous recombination.

1990 • 70 citations

R-ras interacts with rasGAP, neurofibromin and c-raf but does not regulate cell growth or differentiation.

1994 • 65 citations

Characterization of Ral GDP Dissociation Stimulator-like (RGL) Activities to Regulate c-fosPromoter and the GDP/GTP Exchange of Ral

1997 • 63 citations

The Ras-related protein R-ras interacts directly with Raf-1 in a GTP-dependent manner

1994 • 62 citations

Epidermal growth factor regulates the exchange rate of guanine nucleotides on p21ras in fibroblasts.

1993 • 59 citations

[23] In Vitro binding assay for interactions of Rho and Rac with GTPase-activating proteins and effectors

1995 • 23 citations

Deleted Work

1955 • 0 citations