Platelet-activating Factor Acetylhydrolase, and Not Paraoxonase-1, Is the Oxidized Phospholipid Hydrolase of High Density Lipoprotein Particles

Protective effect of high density lipoprotein associated paraoxonase. Inhibition of the biological activity of minimally oxidized low density lipoprotein.

1995 • 1,170 citations

Paraoxonase inhibits high-density lipoprotein oxidation and preserves its functions. A possible peroxidative role for paraoxonase.

1998 • 1,158 citations

Mice lacking serum paraoxonase are susceptible to organophosphate toxicity and atherosclerosis

1998 • 1,078 citations

Paraoxonase prevents accumulation of lipoperoxides in low‐density lipoprotein

1991 • 982 citations

Paraoxonase and Atherosclerosis

2001 • 819 citations

Structural Identification by Mass Spectrometry of Oxidized Phospholipids in Minimally Oxidized Low Density Lipoprotein That Induce Monocyte/Endothelial Interactions and Evidence for Their Presence in Vivo

1997 • 751 citations

Platelet-Activating Factor and Related Lipid Mediators

2000 • 749 citations

Purification of human serum paraoxonase/arylesterase. Evidence for one esterase catalyzing both activities.

1991 • 584 citations

Anti-inflammatory properties of a platelet-activating factor acetylhydrolase

1995 • 529 citations

Human Serum Paraoxonases (PON1) Q and R Selectively Decrease Lipid Peroxides in Human Coronary and Carotid Atherosclerotic Lesions

2000 • 464 citations

Paraoxonase Active Site Required for Protection Against LDL Oxidation Involves Its Free Sulfhydryl Group and Is Different From That Required for Its Arylesterase/Paraoxonase Activities

1998 • 451 citations

Paraoxonase: biochemistry, genetics and relationship to plasma lipoproteins

1996 • 449 citations

Decreased Atherosclerotic Lesion Formation in Human Serum Paraoxonase Transgenic Mice

2002 • 446 citations

Combined Serum Paraoxonase Knockout/Apolipoprotein E Knockout Mice Exhibit Increased Lipoprotein Oxidation and Atherosclerosis

2000 • 422 citations

Human plasma platelet-activating factor acetylhydrolase. Association with lipoprotein particles and role in the degradation of platelet-activating factor.

1987 • 404 citations

Normal high density lipoprotein inhibits three steps in the formation of mildly oxidized low density lipoprotein: steps 2 and 3

2000 • 391 citations

Thrombin stimulates the adherence of neutrophils to human endothelial cells in vitro.

1985 • 380 citations

Human plasma platelet-activating factor acetylhydrolase. Purification and properties.

1987 • 335 citations

Oxidatively modified LDL contains phospholipids with platelet-activating factor-like activity and stimulates the growth of smooth muscle cells.

1995 • 311 citations

Paraoxonase (PON1) Phenotype Is a Better Predictor of Vascular Disease Than Is PON1 ₁₉₂ or PON1 ₅₅ Genotype

2000 • 310 citations

Human plasma platelet-activating factor acetylhydrolase. Oxidatively fragmented phospholipids as substrates

1991 • 308 citations

Platelet-activating factor acetylhydrolase deficiency. A missense mutation near the active site of an anti-inflammatory phospholipase.

1996 • 270 citations

Oxidized Alkyl Phospholipids Are Specific, High Affinity Peroxisome Proliferator-activated Receptor γ Ligands and Agonists

2001 • 262 citations

Genetic-dietary regulation of serum paraoxonase expression and its role in atherogenesis in a mouse model.

1996 • 249 citations

Characterization of cDNA clones encoding rabbit and human serum paraoxonase: the mature protein retains its signal sequence

1991 • 242 citations

An Oxidized Derivative of Phosphatidylcholine is a Substrate for the Platelet-Activating Factor Acetylhydrolase from Human Plasma

1989 • 234 citations

Oxidatively fragmented phosphatidylcholines activate human neutrophils through the receptor for platelet-activating factor

1991 • 221 citations

Plasma Platelet-activating Factor Acetylhydrolase Is a Secreted Phospholipase A2 with a Catalytic Triad

1995 • 217 citations

Platelet-activating factor receptor: gene expression and signal transduction

1995 • 216 citations

Adenovirus-Mediated Gene Transfer of Human Platelet-Activating Factor–Acetylhydrolase Prevents Injury-Induced Neointima Formation and Reduces Spontaneous Atherosclerosis in Apolipoprotein E–Deficient Mice

2001 • 197 citations

Inflammatory Platelet-activating Factor-like Phospholipids in Oxidized Low Density Lipoproteins Are Fragmented Alkyl Phosphatidylcholines

1999 • 186 citations

The role of paraoxonase (PON1) in the detoxication of organophosphates and its human polymorphism

1999 • 175 citations

Vitamin C blocks inflammatory platelet-activating factor mimetics created by cigarette smoking.

1997 • 161 citations

Pharmacogenetics of Drug Metabolism

2009 • 158 citations

Biologically Active Oxidized Phospholipids

1999 • 154 citations

Reconsideration of the catalytic center and mechanism of mammalian paraoxonase/arylesterase.

1995 • 150 citations

Apolipoprotein A-I Promotes the Formation of Phosphatidylcholine Core Aldehydes That Are Hydrolyzed by Paraoxonase (PON-1) during High Density Lipoprotein Oxidation with a Peroxynitrite Donor

2001 • 141 citations

Hydrolysis of platelet-activating factor by human serum paraoxonase

2001 • 139 citations

Evidence That Phospholipid Oxidation Products and/or Platelet-Activating Factor Play an Important Role in Early Atherogenesis

1999 • 139 citations

Paraoxonase protection of LDL against peroxidation is independent of its esterase activity towards paraoxon and is unaffected by the Q→R genetic polymorphism

1999 • 126 citations

Comparison of purified human and rabbit serum paraoxonases.

1995 • 120 citations

Characteristics of the genetically determined allozymic forms of human serum paraoxonase/arylesterase.

1991 • 110 citations

Paraoxonase 1 Overexpression in Mice and Its Effect on High-Density Lipoproteins

2002 • 106 citations

Hydrolysis of platelet-activating factor by human serum paraoxonase

2001 • 89 citations

The active site of human paraoxonase (PON1)

2001 • 87 citations

Multiple Substrates for Paraoxonase-1 during Oxidation of Phosphatidylcholine by Peroxynitrite

2002 • 86 citations

Monocyte Chemoattractant Protein-1 and 5-Lipoxygenase Products Recruit Leukocytes in Response to Platelet-Activating Factor-Like Lipids in Oxidized Low-Density Lipoprotein

2002 • 78 citations

Pefabloc, 4-[2-aminoethyl]benzenesulfonyl fluoride, is a new, potent nontoxic and irreversible inhibitor of PAF-degrading acetylhydrolase

1996 • 74 citations

Effect of cigarette smoking on the levels of platelet-activating factor-like lipid(s) in plasma lipoproteins

1991 • 58 citations

Lysophosphatidylcholine and lyso-PAF display PAF-like activity derived from contaminating phospholipids

2001 • 54 citations

Pharmacogenomic considerations of the paraoxonase polymorphisms

2002 • 50 citations

Identification of 2-azelaoylphosphatidylcholine as one of the cytotoxic products generated during oxyhemoglobin-induced peroxidation of phosphatidylcholine

1988 • 45 citations

Generation of toxic phospholipid(s) during oxyhemoglobin-induced peroxidation of phosphatidylcholines

1988 • 40 citations

Structural identification of phosphatidylcholines having an oxidatively shortened linoleate residue generated through its oxygenation with soybean or rabbit reticulocyte lipoxygenase

2000 • 27 citations

Pralidoxime and l ‐lactate effects in vitro on the inhibition of acetylcholinesterase by paraoxon: pralidoxime does not confer superior protection

2001 • 18 citations

Influence of dicarboxylic phosphatidylcholines on the stability and phase transition of phosphatidylcholine liposomes

1981 • 10 citations