Paraoxonase protection of LDL against peroxidation is independent of its esterase activity towards paraoxon and is unaffected by the Q→R genetic polymorphism

Free radicals, antioxidants, and human disease: curiosity, cause, or consequence?

1994 • 3,002 citations

Randomised controlled trial of vitamin E in patients with coronary disease: Cambridge Heart Antioxidant Study (CHAOS)

1996 • 2,163 citations

Evidence for the presence of oxidatively modified low density lipoprotein in atherosclerotic lesions of rabbit and man.

1989 • 1,914 citations

Atherosclerosis: Basic Mechanisms

1995 • 1,697 citations

Low Density Lipoprotein Oxidation and Its Pathobiological Significance

1997 • 1,642 citations

Protective effect of high density lipoprotein associated paraoxonase. Inhibition of the biological activity of minimally oxidized low density lipoprotein.

1995 • 1,170 citations

Paraoxonase inhibits high-density lipoprotein oxidation and preserves its functions. A possible peroxidative role for paraoxonase.

1998 • 1,158 citations

Paraoxonase prevents accumulation of lipoperoxides in low‐density lipoprotein

1991 • 982 citations

The molecular basis of the human serum paraoxonase activity polymorphism

1993 • 847 citations

High-density lipoprotein inhibits the oxidative modification of low-density lipoprotein

1990 • 836 citations

Protection of low-density lipoprotein against oxidative modification by high-density lipoprotein associated paraoxonase

1993 • 817 citations

Anti-inflammatory HDL becomes pro-inflammatory during the acute phase response. Loss of protective effect of HDL against LDL oxidation in aortic wall cell cocultures.

1995 • 810 citations

A spectrophotometric assay for lipid peroxides in serum lipoproteins using a commercially available reagent.

1989 • 594 citations

Purification of human serum paraoxonase/arylesterase. Evidence for one esterase catalyzing both activities.

1991 • 584 citations

Molecular basis for the polymorphic forms of human serum paraoxonase/arylesterase: glutamine or arginine at position 191, for the respective A or B allozymes.

1993 • 481 citations

Paraoxonase polymorphism Met-Leu54 is associated with modified serum concentrations of the enzyme. A possible link between the paraoxonase gene and increased risk of cardiovascular disease in diabetes.

1997 • 478 citations

Effect of the human serum paraoxonase 55 and 192 genetic polymorphisms on the protection by high density lipoprotein against low density lipoprotein oxidative modification

1998 • 377 citations

Gln-Arg192 polymorphism of paraoxonase and coronary heart disease in type 2 diabetes

1995 • 348 citations

A variant of human paraoxonase/arylesterase (HUMPONA) gene is a risk factor for coronary artery disease.

1995 • 345 citations

Oxidation of High Density Lipoproteins

1998 • 320 citations

Mildly oxidized LDL induces an increased apolipoprotein J/paraoxonase ratio.

1997 • 309 citations

Oxidation of High Density Lipoproteins

1998 • 273 citations

The Gln-Arg191 polymorphism of the human paraoxonase gene (HUMPONA) is not associated with the risk of coronary artery disease in Finns.

1996 • 241 citations

Genetic Polymorphism of Paraoxonase and the Risk of Coronary Heart Disease

1997 • 207 citations

HDL and ApoA Prevent Cell Death of Endothelial Cells Induced by Oxidized LDL

1997 • 202 citations

Apolipoprotein J Is Associated with Paraoxonase in Human Plasma

1994 • 186 citations

Overexpression of apolipoprotein AII in transgenic mice converts high density lipoproteins to proinflammatory particles.

1997 • 183 citations

The Gln/Arg polymorphism of human paraoxonase (PON 192) is not related to myocardial infarction in the ECTIM Study

1996 • 181 citations

Paraoxonase Polymorphism (Gln192-Arg) Is Associated with Coronary Heart Disease in Japanese Noninsulin-Dependent Diabetes Mellitus

1997 • 148 citations

Paraoxonase gene polymorphism in Japanese subjects with coronary heart disease

1996 • 134 citations

Human and rabbit paraoxonases: Purification, cloning, sequencing, mapping and role of polymorphism in organophosphate detoxification

1993 • 109 citations

Paraoxonase Genotypes, Lipoprotein Lipase Activity, and HDL

1996 • 92 citations

Increased Oxidation of LDL in Patients With Coronary Artery Disease Is Independent From Dietary Vitamins E and C

1997 • 61 citations

Oxidisability of low density lipoproteins in patients with carotid or femoral artery atherosclerosis

1995 • 54 citations

Lack of association between carotid intima-media thickness and paraoxonase gene polymorphism in non-insulin dependent diabetes mellitus

1998 • 51 citations

Reduction of phosphatidylcholine hydroperoxide by apolipoprotein A-I: purification of the hydroperoxide-reducing proteins from human blood plasma

1998 • 49 citations