Genetic-dietary regulation of serum paraoxonase expression and its role in atherogenesis in a mouse model.

Single-Step Method of RNA Isolation by Acid Guanidinium Thiocyanate–Phenol–Chloroform Extraction

1987 • 64,270 citations

Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction

1987 • 45,673 citations

THE DISTRIBUTION AND CHEMICAL COMPOSITION OF ULTRACENTRIFUGALLY SEPARATED LIPOPROTEINS IN HUMAN SERUM

1955 • 8,846 citations

Atherosclerosis: Basic Mechanisms

1995 • 1,697 citations

Protective effect of high density lipoprotein associated paraoxonase. Inhibition of the biological activity of minimally oxidized low density lipoprotein.

1995 • 1,170 citations

Paraoxonase prevents accumulation of lipoperoxides in low‐density lipoprotein

1991 • 982 citations

Expression of monocyte chemoattractant protein 1 in macrophage-rich areas of human and rabbit atherosclerotic lesions.

1991 • 879 citations

The molecular basis of the human serum paraoxonase activity polymorphism

1993 • 847 citations

High-density lipoprotein inhibits the oxidative modification of low-density lipoprotein

1990 • 836 citations

Protection of low-density lipoprotein against oxidative modification by high-density lipoprotein associated paraoxonase

1993 • 817 citations

Monocyte transmigration induced by modification of low density lipoprotein in cocultures of human aortic wall cells is due to induction of monocyte chemotactic protein 1 synthesis and is abolished by high density lipoprotein.

1991 • 739 citations

Plasma high density lipoproteins. Metabolism and relationship to atherogenesis.

1990 • 660 citations

Variation in susceptibility to atherosclerosis among inbred strains of mice

1985 • 604 citations

Purification of human serum paraoxonase/arylesterase. Evidence for one esterase catalyzing both activities.

1991 • 584 citations

Serum paraoxonase activity in familial hypercholesterolaemia and insulin-dependent diabetes mellitus

1991 • 504 citations

Molecular basis for the polymorphic forms of human serum paraoxonase/arylesterase: glutamine or arginine at position 191, for the respective A or B allozymes.

1993 • 481 citations

High density lipoprotein is the major carrier of lipid hydroperoxides in human blood plasma from fasting donors.

1992 • 471 citations

Lipopolysaccharide (LPS)-binding protein is carried on lipoproteins and acts as a cofactor in the neutralization of LPS.

1994 • 435 citations

Effect of platelet activating factor-acetylhydrolase on the formation and action of minimally oxidized low density lipoprotein.

1995 • 412 citations

The Role of Oxidized Low-Density Lipoproteins in the Pathogenesis of Atherosclerosis

1992 • 386 citations

Atherosclerosis in Transgenic Mice Overexpressing Apolipoprotein A-II

1993 • 355 citations

Identification of a distinct human high‐density lipoprotein subspecies defined by a lipoprotein‐associated protein, K‐45

1993 • 350 citations

Genetic control of inflammatory gene induction and NF-kappa B-like transcription factor activation in response to an atherogenic diet in mice.

1993 • 291 citations

Ath-1, a gene determining atherosclerosis susceptibility and high density lipoprotein levels in mice.

1987 • 286 citations

Characterization of cDNA clones encoding rabbit and human serum paraoxonase: the mature protein retains its signal sequence

1991 • 242 citations

Genetic evidence for a common pathway mediating oxidative stress, inflammatory gene induction, and aortic fatty streak formation in mice.

1994 • 228 citations

Distribution of paraoxon hydrolytic activity in the serum of patients after myocardial infarction.

1986 • 225 citations

Macrophage colony-stimulating factor mRNA and protein in atherosclerotic lesions of rabbits and humans.

1992 • 219 citations

Minimally modified low density lipoprotein is biologically active in vivo in mice.

1991 • 212 citations

Prevention of endotoxin-induced monokine release by human low- and high-density lipoproteins and by apolipoprotein A-I

1993 • 169 citations

Genetic polymorphism and interethnic variability of plasma paroxonase activity.

1976 • 145 citations

A‐esterase activities in relation to the differential toxicity of pirimiphos‐methyl to birds and mammals

1980 • 135 citations

A Polymorphism of the Paraoxonase Gene Associated With Variation in Plasma Lipoproteins in a Genetic Isolate

1995 • 132 citations

Quantification of human serum paraoxonase by enzyme-linked immunoassay: population differences in protein concentrations

1994 • 132 citations

Influence of the apoA-II gene locus on HDL levels and fatty streak development in mice.

1993 • 130 citations

Priming of Polymorphonuclear Granulocytes by Lipopolysaccharides and Its Complexes With Lipopolysaccharide Binding Protein and High Density Lipoprotein

1990 • 129 citations

Monocyte migration into the subendothelial space of a coculture of adult human aortic endothelial and smooth muscle cells.

1988 • 120 citations

Atherosclerosis: Basic mechanisms: Oxidation, inflammation, and genetics

1996 • 112 citations

Influence of serum paraoxonase polymorphism on serum lipids and apolipoproteins

1991 • 104 citations

A polymorphism affecting apolipoprotein A-II translational efficiency determines high density lipoprotein size and composition.

1990 • 103 citations

Modulation of Endotoxic Activity of Lipopolysaccharide by High-Density Lipoprotein

1991 • 97 citations

The platelet-activating factor acetylhydrolase from human plasma prevents oxidative modification of low-density lipoprotein.

1992 • 93 citations

Phenotypic characterization of the Ath-1 gene controlling high density lipoprotein levels and susceptibility to atherosclerosis.

1990 • 78 citations

Serum esterase activities and hyperlipidaemia in the streptozotocin -diabetic rat

1990 • 65 citations

LPS-induced release of IL-1β, IL-6, IL-8, TNF-α and sCD14 in whole blood and PBMC from persons with high or low levels of HDL-lipoprotein

1994 • 45 citations

Linkage Mapping of 40 Randomly Isolated Liver cDNA Clones in the Mouse

1993 • 42 citations

The Role Of Oxidized Low-Density Lipoproteins In The Pathogenesis Of Atherosclerosis

1992 • 26 citations

Serum paraoxonase and cholineseterase activities in individuals with lipid and glucose metabolism disorders

1993 • 22 citations

Minimally modified low density lipoprotein is biologically active in vivo in mice

1991 • 9 citations