Reconsideration of the catalytic center and mechanism of mammalian paraoxonase/arylesterase.

Paraoxonase prevents accumulation of lipoperoxides in low‐density lipoprotein

1991 • 982 citations

The molecular basis of the human serum paraoxonase activity polymorphism

1993 • 847 citations

Protection of low-density lipoprotein against oxidative modification by high-density lipoprotein associated paraoxonase

1993 • 817 citations

Interfacial Catalysis: the Mechanism of Phospholipase A ₂

1990 • 693 citations

Purification of human serum paraoxonase/arylesterase. Evidence for one esterase catalyzing both activities.

1991 • 584 citations

Purification and Properties of the Phosphotriesterase from Pseudomonas diminuta

1989 • 492 citations

Molecular basis for the polymorphic forms of human serum paraoxonase/arylesterase: glutamine or arginine at position 191, for the respective A or B allozymes.

1993 • 481 citations

Primary structure of Torpedo californica acetylcholinesterase deduced from its cDNA sequence

1986 • 426 citations

Complete amino acid sequence of human serum cholinesterase.

1987 • 374 citations

Identification of a distinct human high‐density lipoprotein subspecies defined by a lipoprotein‐associated protein, K‐45

1993 • 350 citations

Pharmacogenetics of drug metabolism

1980 • 310 citations

The human serum paraoxonase polymorphism: identification of phenotypes by their response to salts.

1983 • 271 citations

Characterization of cDNA clones encoding rabbit and human serum paraoxonase: the mature protein retains its signal sequence

1991 • 242 citations

New perspective on zinc biochemistry: Cocatalytic sites in multi-zinc enzymes

1993 • 238 citations

Apolipoprotein J Is Associated with Paraoxonase in Human Plasma

1994 • 186 citations

Mutagenesis of human acetylcholinesterase. Identification of residues involved in catalytic activity and in polypeptide folding.

1992 • 183 citations

The structure of aconitase

1989 • 183 citations

Mechanism and stereochemical course at phosphorus of the reaction catalyzed by a bacterial phosphotriesterase

1988 • 181 citations

Calcium binding proteins. Elucidating the contributions to calcium affinity from an analysis of species variants and peptide fragments

1990 • 177 citations

Homologous enzymes and biochemical evolution.

1969 • 145 citations

Mutagenesis of essential functional residues in acetylcholinesterase.

1990 • 140 citations

Quantification of human serum paraoxonase by enzyme-linked immunoassay: population differences in protein concentrations

1994 • 132 citations

An efficient site-directed mutagenesis method based on PCR.

1994 • 129 citations

Purification of rabbit and human serum paraoxonase

1991 • 126 citations

Studies on human serum paraoxonase/arylesterase

1993 • 113 citations

Characteristics of the genetically determined allozymic forms of human serum paraoxonase/arylesterase.

1991 • 110 citations

Human and rabbit paraoxonases: Purification, cloning, sequencing, mapping and role of polymorphism in organophosphate detoxification

1993 • 109 citations

Binding of an alpha 2 adrenergic receptor third intracellular loop peptide to G beta and the amino terminus of G alpha.

1994 • 104 citations

Introduction of a cysteine protease active site into trypsin

1989 • 93 citations

Bimetallic binding motifs in organophosphorus hydrolase are important for catalysis and structural organization

1994 • 91 citations

Convergence of active center geometries

1977 • 89 citations

Distinction between ‘A’-esterases and arylesterases. Implications for esterase classification

1987 • 71 citations

Monocyte adhesion and transmigration in atherosclerosis

1994 • 62 citations

Identification of the Histidine Ligands to the Binuclear Metal Center of Phosphotriesterase by Site-Directed Mutagenesis

1994 • 53 citations

Hepatic microsomal detoxification of the organophosphates paraoxon and chlorpyrifos oxon in the mouse.

1983 • 52 citations

ARYLESTERASES

1964 • 42 citations

The role of calcium in the hydrolysis of the organophosphate paraoxon by human serum A-esterase

1995 • 22 citations

Lipoproteins and hydrolysis of organophosphorus compounds

1993 • 22 citations

Solubilization and purification of A-esterase from mouse hepatic microsomes

1994 • 15 citations

Kinetic mechanism of the detoxification of the organophosphate paraoxon by human serum A-esterase.

1994 • 11 citations

Structural studies on copper-containing plant oxidases

1992 • 9 citations