Truncated Thioredoxin: Physiological Functions and Mechanism

THE NF-κB AND IκB PROTEINS: New Discoveries and Insights

1996 • 5,936 citations

Mammalian thioredoxin is a direct inhibitor of apoptosis signal-regulating kinase (ASK) 1

1998 • 2,360 citations

THIOREDOXIN

1985 • 1,885 citations

Current Concepts of the Pathogenesis of the Acute Coronary Syndromes

2001 • 1,568 citations

CD40 AND CD154 IN CELL-MEDIATED IMMUNITY

1998 • 1,546 citations

INDUCTION OF TH1 AND TH2 CD4⁺T CELL RESPONSES:The Alternative Approaches

1997 • 1,464 citations

REDOX REGULATION OF CELLULAR ACTIVATION

1997 • 1,121 citations

[21] Thioredoxin and thioredoxin reductase

1995 • 932 citations

Thioredoxin catalyzes the reduction of insulin disulfides by dithiothreitol and dihydrolipoamide.

1979 • 907 citations

Type 1/Type 2 Immunity in Infectious Diseases

2001 • 854 citations

AP-1 transcriptional activity is regulated by a direct association between thioredoxin and Ref-1

1997 • 836 citations

Thioredoxin —a fold for all reasons

1995 • 799 citations

The CD40/CD154 receptor/ligand dyadRID="†"ID="†" Review

2001 • 730 citations

Distinct effects of thioredoxin and antioxidants onthe activation of transcription factors NF-kappa B and AP-1.

1994 • 694 citations

Human CD14 mediates recognition and phagocytosis of apoptotic cells

1998 • 685 citations

Distinct Roles of Thioredoxin in the Cytoplasm and in the Nucleus

1999 • 597 citations

Secretion of thioredoxin by normal and neoplastic cells through a leaderless secretory pathway.

1992 • 463 citations

Three-dimensional structure of Escherichia coli thioredoxin-S2 to 2.8 A resolution.

1975 • 435 citations

Structural and functional relations among thioredoxins of different species

1991 • 363 citations

Thioredoxin, a Redox Enzyme Released in Infection and Inflammation, Is a Unique Chemoattractant for Neutrophils, Monocytes, and T Cells

1999 • 340 citations

Evidence that the endogenous heat-stable glucocorticoid receptor-activating factor is thioredoxin.

1983 • 309 citations

Thioredoxin and thioredoxin reductase gene expression in human tumors and cell lines, and the effects of serum stimulation and hypoxia.

1996 • 309 citations

Differentiation and stability of T helper 1 and 2 cells derived from naive human neonatal CD4+ T cells, analyzed at the single-cell level.

1996 • 287 citations

Adult T-cell leukemia-derived factor/thioredoxin, produced by both human T-lymphotropic virus type I- and Epstein-Barr virus-transformed lymphocytes, acts as an autocrine growth factor and synergizes with interleukin 1 and interleukin 2.

1990 • 283 citations

Elevation of plasma thioredoxin levels in HIV-infected individuals

1996 • 209 citations

Nucleoredoxin, Glutaredoxin, and Thioredoxin Differentially Regulate NF-κB, AP-1, and CREB Activation in HEK293 Cells

2000 • 205 citations

Direct Association with Thioredoxin Allows Redox Regulation of Glucocorticoid Receptor Function

1999 • 205 citations

Thioredoxin: friend or foe in human disease?

2005 • 194 citations

Widespread expression of thioredoxin and thioredoxin reductase in non-small cell lung carcinoma.

2001 • 187 citations

Thioredoxin and Its Related Molecules: Update 2005

2005 • 180 citations

Serum thioredoxin levels as an indicator of oxidative stress in patients with hepatitis C virus infection

2000 • 177 citations

Redox Regulation of Caspase-3(-like) Protease Activity: Regulatory Roles of Thioredoxin and Cytochromec

1998 • 174 citations

Thioredoxin: a redox-regulating cellular cofactor for glucocorticoid hormone action. Cross talk between endocrine control of stress response and cellular antioxidant defense system.

1996 • 170 citations

Thioredoxin as a potent costimulus of cytokine expression.

1996 • 166 citations

Proof that the endogenous, heat-stable glucocorticoid receptor-activating factor is thioredoxin.

1985 • 158 citations

Tissue distribution and subcellular localization of bovine thioredoxin determined by radioimmunoassay

1978 • 150 citations

Involvement of thioredoxin in rheumatoid arthritis: its costimulatory roles in the TNF-alpha-induced production of IL-6 and IL-8 from cultured synovial fibroblasts.

1999 • 147 citations

Chronic elevation of plasma thioredoxin: Inhibition of chemotaxis and curtailment of life expectancy in AIDS

2001 • 146 citations

Expression and growth-promoting effect of adult t-cell leukemia-derived factor a human thioredoxin homologue in hepatocellular carcinoma

1992 • 145 citations

Measurements of Plasma Glutaredoxin and Thioredoxin in Healthy Volunteers and During Open-Heart Surgery

1998 • 126 citations

Similarities and differences in the thioredoxin superfamily

2005 • 125 citations

Involvement of Thioredoxin in Rheumatoid Arthritis: Its Costimulatory Roles in the TNF-α-Induced Production of IL-6 and IL-8 from Cultured Synovial Fibroblasts

1999 • 122 citations

Truncated Thioredoxin Is a Mitogenic Cytokine for Resting Human Peripheral Blood Mononuclear Cells and Is Present in Human Plasma

2000 • 113 citations

A CD4⁺ T cell line-secreted factor, growth promoting for normal and leukemic B cells, identified as thioredoxin

1995 • 105 citations

Link Between Macrophage Migration Inhibitory Factor and Cellular Redox Regulation

2005 • 99 citations

IL-2 receptor(p55)/Tac-inducing factor. Purification and characterization of adult T cell leukemia-derived factor.

1988 • 90 citations

Thioredoxin Expression and Localization in Human Cell Lines: Detection of Full-Length and Truncated Species

1997 • 84 citations

Activation of Nuclear Factor- κ B Transcriptional Activity in Airway Epithelial Cells by Thioredoxin but Not by N-Acetyl-Cysteine and Glutathione

2001 • 84 citations

Expression of thioredoxin is enhanced in atherosclerotic plaques and during neointima formation in rat arteries.

1998 • 80 citations

A yeast two-hybrid knockout strain to explore thioredoxin-interacting proteinsin vivo

2005 • 79 citations

Monocyte CD14: a multifunctional receptor engaged in apoptosis from both sides

1999 • 78 citations

Truncated thioredoxin (Trx80) induces production of interleukin-12 and enhances CD14 expression in human monocytes

2001 • 76 citations

Localization of thioredoxin in the rat brain and functional implications

1995 • 74 citations

lnterleukin-12

1995 • 72 citations

Serum thioredoxin levels as an indicator of oxidative stress in patients with hepatitis C virus infection

2000 • 71 citations

The Regulation and Biological Activity of Interleukin 12

1998 • 69 citations

Role of ATL-derived factor (ADF) in the normal and abnormal cellular activation: Involvement of dithiol related reduction

1990 • 64 citations

Induction of Thioredoxin, a Redox-Active Protein, by Ovarian Steroid Hormones during Growth and Differentiation of Endometrial Stromal Cells in Vitro**This work was supported by a Grant-in-Aid for Scientific Research, Japan.

1999 • 62 citations

Human eosinophil cytotoxicity-enhancing factor. Eosinophil-stimulating and dithiol reductase activities of biosynthetic (recombinant) species with COOH-terminal deletions.

1993 • 62 citations

Opposing regulatory effects of thioredoxin and eosinophil cytotoxicity-enhancing factor on the development of human immunodeficiency virus 1.

1994 • 62 citations

Thioredoxin Blood Level Increases After Severe Burn Injury

2000 • 60 citations

Differential expression of glutaredoxin and thioredoxin during monocytic differentiation

1999 • 58 citations

Thioredoxin alters the matrix metalloproteinase/tissue inhibitors of metalloproteinase balance and stimulates human SK‐N‐SH neuroblastoma cell invasion

2001 • 58 citations

Modulation of eosinophil cytotoxicity by blood mononuclear cells from healthy subjects and patients with chronic Schistosomiasis mansoni

1984 • 54 citations

Binding of JAB1/CSN5 to MIF is mediated by the MPN domain but is independent of the JAMM motif

2005 • 51 citations

Human eosinophil cytotoxicity-enhancing factor: purification, physical characteristics, and partial amino acid sequence of an active polypeptide

1991 • 51 citations

Secretion of 10-kDa and 12-kDa Thioredoxin Species from Blood Monocytes and Transformed Leukocytes

2000 • 50 citations

Enhancement by monokines of leukotriene generation by human eosinophils and neutrophils stimulated with calcium ionophore A23187.

1986 • 47 citations

Human eosinophil cytotoxicity-enhancing factor. II. Multiple forms synthesized by U937 cells and their relationship to thioredoxin/adult T cell leukemia-derived factor.

1991 • 46 citations

Activation of human eosinophils by monokines and lymphokines: Source and biochemical characteristics of the eosinophil cytotoxicity-enhancing activity produced by blood mononuclear cells

1985 • 45 citations

Production and secretion of thioredoxin from transformed human trophoblast cells

1998 • 45 citations

Truncated thioredoxin (Trx80) exerts unique mitogenic cytokine effects via a mechanism independent of thiol oxido‐reductase activity

2003 • 41 citations

Roles of ICAM-3 and CD 14 in the recognition and phagocytosis of apoptotic cells by macrophages

1998 • 40 citations

Human eosinophil cytotoxicity-enhancing factor. Purification, physical characteristics, and partial amino acid sequence of an active polypeptide.

1989 • 36 citations

Characterization of a factor from the U937 cell line that enhances the toxicity of human eosinophils to Schistosoma mansoni larvae.

1987 • 33 citations

Detection of Membrane Associated Thioredoxin on Human Cell Lines

1997 • 33 citations

Induction of thioredoxin in human lymphocytes with low-dose ionizing radiation

1997 • 32 citations

Lymphocyte transformation and thiol compounds: The role of ADF/thioredoxin as an endogenous reducing agent

1992 • 31 citations

Increased expression of human thioredoxin/adult T cell leukemia–derived factor in Sjögren's syndrome

1996 • 31 citations

Requirements for the Different Cysteines in the Chemotactic and Desensitizing Activity of Human Thioredoxin

2005 • 30 citations

Increase in Thioredoxin Activity of Intestinal Epithelial Cells Mediated by Oxidative Stress.

1999 • 29 citations

Induction of Thioredoxin, a Redox-Active Protein, by Ovarian Steroid Hormones during Growth and Differentiation of Endometrial Stromal Cells in Vitro

1999 • 27 citations

Thioredoxin Levels in the Sera of Untreated Viral Hepatitis Patients and Those Treated with Glycyrrhizin or Ursodeoxycholic Acid

2000 • 22 citations

Thioredoxin and Its Role in Premature Newborn Biology

2005 • 22 citations

Expression of adult T-cell leukaemia-derived factor, a human thioredoxin homologue, in the human ovary throughout the menstrual cycle

1992 • 21 citations

Thioredoxin, thioredoxin reductase and tumour necrosis factor-α expression in melanoma cells : correlation to resistance against cytotoxic attack

2000 • 17 citations

Selection of U937 histiocytic lymphoma cells highly responsive to phorbol ester-induced differentiation using monoclonal antibody to the eosinophil cytotoxicity-enhancing factor

1990 • 7 citations

Eosinophil cytotoxicity enhancing factor: purification, characterization and immunocytochemical localization on the monocyte surface

1990 • 5 citations