Back to search

Selective targeting of lysosomal cysteine proteases with radiolabeled electrophilic substrate analogs

Data up to Jan 2025

Published2000
Citations221
References40

Total Citations Per Year

Abstract

References (40)

A Second Generation Force Field for the Simulation of Proteins, Nucleic Acids, and Organic Molecules

1995 • 12,826 citations

Iterative partial equalization of orbital electronegativity—a rapid access to atomic charges

1980 • 3,898 citations

Handbook of Proteolytic Enzymes

2004 • 2,698 citations

Textbook of Rheumatology

1985 • 1,671 citations

The Handbook of proteolytic enzymes

1998 • 1,123 citations

Human cytotrophoblasts adopt a vascular phenotype as they differentiate. A strategy for successful endovascular invasion?

1997 • 959 citations

EMERGING ROLES FOR CYSTEINE PROTEASES IN HUMAN BIOLOGY

1997 • 767 citations

92-kD type IV collagenase mediates invasion of human cytotrophoblasts.

1991 • 722 citations

Cysteine Proteases and Their Inhibitors

1997 • 720 citations

Textbook of Rheumatology.

1988 • 593 citations

Integrin switching regulates normal trophoblast invasion

1994 • 580 citations

Vinyl Sulfones as Mechanism-Based Cysteine Protease Inhibitors

1995 • 496 citations

Adhesive and degradative properties of human placental cytotrophoblast cells in vitro.

1989 • 477 citations

Covalent modification of the active site threonine of proteasomal β subunits and theEscherichia colihomolog HslV by a new class of inhibitors

1997 • 441 citations

Cathepsin S activity regulates antigen presentation and immunity.

1998 • 307 citations

Molecular cloning and expression of human alveolar macrophage cathepsin S, an elastinolytic cysteine protease.

1992 • 304 citations

Human placenta protein-tyrosine-phosphatase: amino acid sequence and relationship to a family of receptor-like proteins.

1989 • 276 citations

Novel epoxysuccinyl peptides Selective inhibitors of cathepsin B, in vitro

1991 • 271 citations

Role of the Occluding Loop in Cathepsin B Activity

1997 • 258 citations

Trophoblast pseudo-vasculogenesis: faking it with endothelial adhesion receptors

1998 • 246 citations

Novel epoxysuccinyl peptides A selective inhibitor of cathepsin B, in vivo

1991 • 213 citations

Inclusion of Solvation in Ligand Binding Free Energy Calculations Using the Generalized-Born Model

1999 • 208 citations

CA074 methyl ester: A proinhibitor for intracellular cathepsin B

1992 • 200 citations

Cathepsin B and its endogenous inhibitors: the role in tumor malignancy

1990 • 187 citations

Substrate binding and sequence preference of the proteasome revealed by active-site-directed affinity probes

1998 • 179 citations

Crystal structure of cathepsin B inhibited with CA030 at 2.0-.ANG. resolution: A basis for the design of specific epoxysuccinyl inhibitors

1995 • 177 citations

Endosomal proteolysis and MHC class II function

1998 • 168 citations

Peptidyl vinyl sulphones: a new class of potent and selective cysteine protease inhibitors: S2P2 specificity of human cathepsin O2 in comparison with cathepsins S and L

1996 • 139 citations

Cysteinyl Proteinases and Their Selective Inactivation

1990 • 136 citations

The LMP antigens: A stable MHC-controlled multisubunit protein complex

1986 • 93 citations

Switch of CD4+ T Cell Differentiation from Th2 to Th1 by Treatment with Cathepsin B Inhibitor in Experimental Leishmaniasis

1998 • 91 citations

Participation of cathepsin B in processing of antigen presentation to MHC class II

1993 • 87 citations

The identification of active forms of cysteine proteinases in Kirsten-virus-transformed mouse fibroblasts by use of a specific radiolabelled inhibitor

1989 • 86 citations

Mechanistic Studies on the Inactivation of Papain by Epoxysuccinyl Inhibitors

1996 • 69 citations

Abnormal expression of lysosomal cysteine proteinases in muscle wasting diseases

1987 • 64 citations

Quantification of cathepsins B and L in cells

1998 • 58 citations

Epoxysuccinyl dipeptides as selective inhibitors of cathepsin B

1993 • 45 citations

Control of breast tumor cell growth using a targeted cysteine protease inhibitor.

1998 • 21 citations

Novel physiological functions of cathepsins B and L on antigen processing and osteoclastic bone resorption

1998 • 18 citations

Design of a transferrin–proteinase inhibitor conjugate to probe for active cysteine proteinases in endosomes

1998 • 11 citations

Cited By (0)

Loading...
Selective targeting of lysosomal cysteine proteases with radiolabeled electrophilic… (2000) – Chemistry & Biology | Metascience Observatory Explorer