Human cytotrophoblasts adopt a vascular phenotype as they differentiate. A strategy for successful endovascular invasion?

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Requirement of Vascular Integrin α _v β ₃ for Angiogenesis

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Integrin αvβ3 antagonists promote tumor regression by inducing apoptosis of angiogenic blood vessels

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Morphogenetic roles of classic cadherins

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A Class I Antigen, HLA-G, Expressed in Human Trophoblasts

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Preeclampsia is associated with failure of human cytotrophoblasts to mimic a vascular adhesion phenotype. One cause of defective endovascular invasion in this syndrome?

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Integrin distribution in malignant melanoma: association of the beta 3 subunit with tumor progression.

1990 • 771 citations

92-kD type IV collagenase mediates invasion of human cytotrophoblasts.

1991 • 722 citations

Distribution patterns of extracellular matrix components and adhesion receptors are intricately modulated during first trimester cytotrophoblast differentiation along the invasive pathway, in vivo.

1992 • 669 citations

A novel endothelial-specific membrane protein is a marker of cell-cell contacts.

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Pre-eclampsia and the placenta

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Integrin switching regulates normal trophoblast invasion

1994 • 580 citations

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1995 • 573 citations

Hypoxia alters early gestation human cytotrophoblast differentiation/invasion in vitro and models the placental defects that occur in preeclampsia.

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Human placental HLA-G expression is restricted to differentiated cytotrophoblasts.

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Embryonic stem cells differentiate in vitro to endothelial cells through successive maturation steps

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Adhesive and degradative properties of human placental cytotrophoblast cells in vitro.

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1983 • 396 citations

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1992 • 380 citations

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Soluble 80‐kd fragment of cell‐CAM 120/80 disrupts cell‐cell adhesion

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Catenin-dependent and -independent Functions of Vascular Endothelial Cadherin

1995 • 220 citations

Pre-eclampsia is associated with an excess of proliferative immature intermediate trophoblast

1995 • 211 citations

Extracellular matrix 5: Adhesive interactions in early mammalian embryogenesis, implantation, and placentation

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E‐cadherin as a tumor (invasion) suppressor gene

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Trophoblast differentiation during formation of anchoring villi in a model of the early human placenta in vitro

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Human smooth muscle VLA-1 integrin: purification, substrate specificity, localization in aorta, and expression during development.

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Early stages of trophoblastic invasion of the maternal vascular system during implantation in the macaque and baboon

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Immunohistochemical localization of vascular endothelial growth factor in the human placenta

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Cell-specific metallothionein gene expression in mouse decidua and placentae

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Trophoblastic invasion and modification of uterine veins during placental development in macaques

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THE ANATOMY OF THE MATERNAL SIDE OF THE PLACENTA

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Isolation and purification of microvascular endothelium from human decidual tissue in the late phase of pregancy

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New developments in pre-eclampsia

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Changes in Integrin Expression Reflect a Stepwise Differentiation Program in Mouse and Human Trophoblast

1994 • 3 citations