Triggering TLR signaling in vaccination

Toll-Like Receptors

2003 • 6,127 citations

Toll-like receptor control of the adaptive immune responses

2004 • 4,092 citations

Interleukin-12 and the regulation of innate resistance and adaptive immunity

2003 • 3,689 citations

Toll Pathway-Dependent Blockade of CD4 ⁺ CD25 ⁺ T Cell-Mediated Suppression by Dendritic Cells

2003 • 2,023 citations

Chromatin–IgG complexes activate B cells by dual engagement of IgM and Toll-like receptors

2002 • 1,877 citations

Efficacy of BCG Vaccine in the Prevention of Tuberculosis

1994 • 1,875 citations

Recognition of single-stranded RNA viruses by Toll-like receptor 7

2004 • 1,777 citations

Host Defense Mechanisms Triggered by Microbial Lipoproteins Through Toll-Like Receptors

1999 • 1,679 citations

Toll-like receptors control activation of adaptive immune responses

2001 • 1,374 citations

Lipopolysaccharide-enhanced, Toll-like Receptor 4–dependent T Helper Cell Type 2 Responses to Inhaled Antigen

2002 • 1,172 citations

Inflammatory stimuli induce accumulation of MHC class II complexes on dendritic cells

1997 • 1,143 citations

Placebo‐Controlled Phase 3 Trial of a Recombinant Glycoprotein 120 Vaccine to Prevent HIV‐1 Infection

2005 • 916 citations

Toll-like receptor 3 promotes cross-priming to virus-infected cells

2005 • 902 citations

Toll-Like Receptor 4-Dependent Activation of Dendritic Cells by β-Defensin 2

2002 • 885 citations

Type 1/Type 2 Immunity in Infectious Diseases

2001 • 854 citations

Human Toll-Like Receptors Mediate Cellular Activation by Mycobacterium tuberculosis

1999 • 813 citations

Toll-Like Receptor 8-Mediated Reversal of CD4 ⁺ Regulatory T Cell Function

2005 • 734 citations

Vaccination against Lyme Disease with RecombinantBorrelia burgdorferiOuter-Surface Lipoprotein A with Adjuvant

1998 • 715 citations

Rapid and strong human CD8+ T cell responses to vaccination with peptide, IFA, and CpG oligodeoxynucleotide 7909

2005 • 619 citations

Cutting Edge: Preferentially the R-Stereoisomer of the Mycoplasmal Lipopeptide Macrophage-Activating Lipopeptide-2 Activates Immune Cells Through a Toll-Like Receptor 2- and MyD88-Dependent Signaling Pathway

2000 • 584 citations

Hemagglutinin Protein of Wild-Type Measles Virus Activates Toll-Like Receptor 2 Signaling

2002 • 498 citations

Active specific immunotherapy for stage II and stage III human colon cancer: a randomised trial

1999 • 495 citations

CD40 activation in vivo overcomes peptide-induced peripheral cytotoxic T-lymphocyte tolerance and augments anti-tumor vaccine efficacy

1999 • 463 citations

Upregulation of costimulatory molecules induced by lipopolysaccharide and double-stranded RNA occurs by Trif-dependent and Trif-independent pathways

2003 • 450 citations

Lymphoid follicle destruction and immunosuppression after repeated CpG oligodeoxynucleotide administration

2004 • 437 citations

Persistent Toll-like receptor signals are required for reversal of regulatory T cell–mediated CD8 tolerance

2004 • 433 citations

Hyporesponsiveness to vaccination with Borrelia burgdorferi OspA in humans and in TLR1- and TLR2-deficient mice

2002 • 432 citations

Maturation of Human Dendritic Cells by Cell Wall Skeleton ofMycobacterium bovisBacillus Calmette-Guérin: Involvement of Toll-Like Receptors

2000 • 405 citations

The Toll-Like Receptor 5 Stimulus Bacterial Flagellin Induces Maturation and Chemokine Production in Human Dendritic Cells

2003 • 399 citations

Cooperation of Toll-Like Receptor 2 and 6 for Cellular Activation by Soluble Tuberculosis Factor andBorrelia burgdorferiOuter Surface Protein A Lipoprotein: Role of Toll-Interacting Protein and IL-1 Receptor Signaling Molecules in Toll-Like Receptor 2 Signaling

2001 • 388 citations

CD27 and CD70 in T cell and B cell activation

2005 • 371 citations

Microbial Lipopeptides Stimulate Dendritic Cell Maturation Via Toll-Like Receptor 2

2001 • 360 citations

Efficacy of BCG vaccine in the prevention of tuberculosis. Meta-analysis of the published literature

1994 • 349 citations

The immunobiology of the TLR9 subfamily

2004 • 339 citations

Use of CpG oligodeoxynucleotides as immune adjuvants

2004 • 304 citations

Cutting Edge: Immune Stimulation by Neisserial Porins Is Toll-Like Receptor 2 and MyD88 Dependent

2002 • 295 citations

Fatal Mycobacterium tuberculosis infection despite adaptive immune response in the absence of MyD88

2004 • 294 citations

A Subset of Toll-Like Receptor Ligands Induces Cross-presentation by Bone Marrow-Derived Dendritic Cells

2003 • 292 citations

CD40 Ligation Releases Immature Dendritic Cells from the Control of Regulatory CD4+CD25+ T Cells

2003 • 292 citations

Mediators of Innate Immunity That Target Immature, But Not Mature, Dendritic Cells Induce Antitumor Immunity When Genetically Fused with Nonimmunogenic Tumor Antigens

2001 • 280 citations

Immunostimulatory DNA-based vaccines induce cytotoxic lymphocyte activity by a T-helper cell-independent mechanism

2000 • 263 citations

Bacterial Flagellin Is an Effective Adjuvant for CD4+ T Cells In Vivo

2002 • 260 citations

In the Absence of IL-12, CD4+ T Cell Responses to Intracellular Pathogens Fail to Default to a Th2 Pattern and Are Host Protective in an IL-10−/− Setting

2002 • 258 citations

Taking a Toll on human disease: Toll-like receptor 4 agonists as vaccine adjuvants and monotherapeutic agents

2004 • 253 citations

Fatal Mycobacterium tuberculosis infection despite adaptive immune response in the absence of MyD88

2004 • 246 citations

A totally synthetic vaccine of generic structure that targets Toll-like receptor 2 on dendritic cells and promotes antibody or cytotoxic T cell responses

2004 • 232 citations

TLR3 in antiviral immunity: key player or bystander?

2005 • 220 citations

Vaccination with Plasmid DNA Activates Dendritic Cells via Toll-Like Receptor 9 (TLR9) but Functions in TLR9-Deficient Mice

2003 • 206 citations

Immunization with HIV-1 Gag Protein Conjugated to a TLR7/8 Agonist Results in the Generation of HIV-1 Gag-Specific Th1 and CD8+ T Cell Responses

2005 • 187 citations

Vaccinology: past achievements, present roadblocks and future promises

2003 • 173 citations

Lipopolysaccharide Binding Protein Binds to Triacylated and Diacylated Lipopeptides and Mediates Innate Immune Responses

2004 • 156 citations

CpG-DNA Aided Cross-Priming by Cross-Presenting B Cells

2004 • 140 citations

Inherited disorders of human Toll‐like receptor signaling: immunological implications

2005 • 136 citations

Factors and signals that govern the migration of dendritic cells via lymphatics: recent advances

2004 • 129 citations

Immunostimulatory CpG Oligodeoxynucleotides Enhance the Immune Response to Vaccine Strategies Involving Granulocyte-Macrophage Colony-Stimulating Factor

1998 • 124 citations

The impact of imiquimod, a Toll-like receptor-7 ligand (TLR7L), on the immunogenicity of melanoma peptide vaccination with adjuvant Flt3 ligand.

2004 • 122 citations

Haemophilus influenzae Type b-Outer Membrane Protein Complex Glycoconjugate Vaccine Induces Cytokine Production by Engaging Human Toll-Like Receptor 2 (TLR2) and Requires the Presence of TLR2 for Optimal Immunogenicity

2004 • 121 citations

The use of Toll-like receptor-7 agonist in the treatment of basal cell carcinoma: an overview

2003 • 121 citations

Combined dendritic cell- and CpG oligonucleotide-based immune therapy cures large murine tumors that resist chemotherapy

2002 • 118 citations

Adjuvant-Mediated Tumor Regression and Tumor-Specific Cytotoxic Response Are Impaired in MyD88-Deficient Mice

2004 • 105 citations

Development of a DNA Vaccine Designed to Induce Cytotoxic T Lymphocyte Responses to Multiple Conserved Epitopes in HIV-1

2003 • 104 citations

Toll-Like Receptor 2 Ligands as Adjuvants for Human Th1 Responses

2003 • 100 citations

TLR9^−/− and TLR9^+/+ mice display similar immune responses to a DNA vaccine

2004 • 98 citations

Lipopeptide epitopes extended by an N^ϵ‐palmitoyl‐lysine moiety increase uptake and maturation of dendritic cells through a Toll‐like receptor‐2 pathway and trigger a Th1‐dependent protective immunity

2004 • 93 citations

TLR9 pathway is involved in adjuvant effects of plasmid DNA-based vaccines

2004 • 87 citations

Augmentation of the migratory ability of DC-based vaccine into regional lymph nodes by efficient CCR7 gene transduction

2004 • 81 citations

Prime-Boost Vaccination with HIV-1 Gag Protein and Cytosine Phosphate Guanosine Oligodeoxynucleotide, Followed by Adenovirus, Induces Sustained and Robust Humoral and Cellular Immune Responses

2003 • 79 citations

Cutting Edge: Link Between Innate and Adaptive Immunity: Toll-Like Receptor 2 Internalizes Antigen for Presentation to CD4+ T Cells and Could Be an Efficient Vaccine Target

2003 • 75 citations

Topical delivery of imiquimod to a mouse model as a novel adjuvant for human immunodeficiency virus (HIV) DNA

2004 • 66 citations

Immunopotentiation of DNA vaccine against herpes simplex virus via co-delivery of plasmid DNA expressing CCR7 ligands

2001 • 65 citations

Resiquimod is a modest adjuvant for HIV-1 gag-based genetic immunization in a mouse model

2004 • 65 citations

CancerVax, An Allogeneic Tumor Cell Vaccine, Induces Specific Humoral and Cellular Immune Responses in Advanced Colon Cancer

2001 • 57 citations

Signaling through CD14 Attenuates the Inflammatory Response toBorrelia burgdorferi, the Agent of Lyme Disease

2005 • 56 citations

Novel synthetic LPS receptor agonists boost systemic and mucosal antibody responses in mice

2003 • 50 citations

DNA Array and Biological Characterization of the Impact of the Maturation Status of Mouse Dendritic Cells on Their Phenotype and Antitumor Vaccination Efficacy

2001 • 40 citations

Current and new strategies in immunotherapy for superficial bladder cancer

2004 • 33 citations

Tripalmitoyl-S-Glyceryl-Cysteine-Dependent OspA Vaccination of Toll-Like Receptor 2-Deficient Mice Results in Effective Protection fromBorrelia burgdorferiChallenge

2003 • 28 citations

Activation of Human Dendritic Cells Is Modulated by Components of the Outer Membranes of Neisseria meningitidis

2003 • 26 citations

Recombinant Herpes Simplex Virus Type 1 (HSV-1) Codelivering Interleukin-12p35 as a Molecular Adjuvant Enhances the Protective Immune Response against Ocular HSV-1 Challenge

2005 • 26 citations

Protection of mice against Philadelphia chromosome-positive acute lymphoblastic leukemia by cell-based vaccination using nonviral, minimalistic expression vectors and immunomodulatory oligonucleotides.

2003 • 21 citations

Challenges in the Search for an HIV Vaccine

2003 • 19 citations

Induction of Tumor Regression by Administration of B7-Ig Fusion Proteins: Mediation by Type 2 CD8+ T Cells and Dependence on IL-4 Production

2004 • 18 citations