Immunostimulatory DNA-based vaccines induce cytotoxic lymphocyte activity by a T-helper cell-independent mechanism

CpG motifs in bacterial DNA trigger direct B-cell activation

1995 • 3,543 citations

T-cell help for cytotoxic T lymphocytes is mediated by CD40–CD40L interactions

1998 • 2,615 citations

Interleukin-12: A Proinflammatory Cytokine with Immunoregulatory Functions that Bridge Innate Resistance and Antigen-Specific Adaptive Immunity

1995 • 2,437 citations

A conditioned dendritic cell can be a temporal bridge between a CD4+ T-helper and a T-killer cell

1998 • 2,373 citations

Help for cytotoxic-T-cell responses is mediated by CD40 signalling

1998 • 2,106 citations

Immunostimulatory DNA Sequences Necessary for Effective Intradermal Gene Immunization

1996 • 1,078 citations

CpG Oligodeoxynucleotides Act as Adjuvants that Switch on T Helper 1 (Th1) Immunity

1997 • 1,008 citations

Immunostimulatory DNA sequences function as T helper-1-promoting adjuvants

1997 • 919 citations

A Phagosome-to-Cytosol Pathway for Exogenous Antigens Presented on MHC Class I Molecules

1995 • 882 citations

Cloned dendritic cells can present exogenous antigens on both MHC class I and class II molecules.

1997 • 837 citations

CpG DNA Is a Potent Enhancer of Specific Immunity in Mice Immunized with Recombinant Hepatitis B Surface Antigen

1998 • 684 citations

Phagocytic processing of bacterial antigens for class I MHC presentation to T cells

1993 • 625 citations

Activation of Cutaneous Dendritic Cells by CpG-Containing Oligodeoxynucleotides: A Role for Dendritic Cells in the Augmentation of Th1 Responses by Immunostimulatory DNA

1998 • 543 citations

Helper activity is required for the in vivo generation of cytotoxic T lymphocytes

1982 • 511 citations

Gene vaccination with naked plasmid DNA: mechanism of CTL priming.

1996 • 494 citations

Unique palindromic sequences in synthetic oligonucleotides are required to induce IFN [correction of INF] and augment IFN-mediated [correction of INF] natural killer activity.

1992 • 480 citations

Antitumor Activity of Deoxyribonucleic Acid Fraction From <italic>Mycobacterium bovis</italic> BCG. I. Isolation, Physicochemical Characterization, and Antitumor Activity<xref ref-type="fn" rid="FN2">2</xref>

1984 • 471 citations

The Role of CD40 Ligand in Costimulation and T‐Cell Activation

1996 • 441 citations

CpG‐containing synthetic oligonucleotides promote B and cytotoxic T cell responses to protein antigen: A new class of vaccine adjuvants

1997 • 390 citations

Induction of antitumor immunity using bone marrow-generated dendritic cells.

1996 • 323 citations

Major histocompatibility complex class I presentation of peptides derived from soluble exogenous antigen by a subset of cells engaged in phagocytosis.

1995 • 300 citations

Recycling MHC class I molecules and endosomal peptide loading

1999 • 290 citations

CD28-B7 interactions allow the induction of CD8+ cytotoxic T lymphocytes in the absence of exogenous help.

1993 • 274 citations

The role of CpG dinucleotides in DNA vaccines

1998 • 251 citations

Loss of antigen-presenting molecules (MHC class I and TAP-1) in lung cancer

1996 • 186 citations

Three‐cell‐type clusters of T cells with antigen‐presenting cells best explain the epitope linkage and noncognate requirements of the in vivo cytolytic response

1987 • 141 citations

Enhancement of antigen-presenting cell surface molecules involved in cognate interactions by immunostimulatory DNA sequences

1999 • 112 citations

Oligonucleotide Adjuvants for T Helper 1 (Th1)–specific Vaccination

1997 • 109 citations

Immunostimulatory DNA Is a Potent Mucosal Adjuvant

1998 • 103 citations

Antitumor Activity of the DNA Fraction from <italic>Mycobacterium bovis</italic> BCG. II. Effects on Various Syngeneic Mouse Tumors<xref ref-type="fn" rid="FN2">2</xref><xref ref-type="fn" rid="FN3">3</xref>

1985 • 79 citations

Transforming growth factor-beta and cancer: a love-hate relationship?

1997 • 76 citations

The Role of B7-1 and B7-2 Costimulation for the Generation of CTL Responses In Vivo

1998 • 73 citations

Immunosuppressive Factors: Role in Cancer Development and Progression

1998 • 63 citations

Suppression of MHC class I antigens in oncogenic transformants: association with decreased recognition by cytotoxic T lymphocytes.

1996 • 54 citations

B-Cell Differentiation

2020 • 39 citations

Regulation of major histocompatibility complex class I expression by NF-κB-related proteins in breast cancer cells

1998 • 33 citations

B Cell Differentiation

1993 • 19 citations