TLR9 pathway is involved in adjuvant effects of plasmid DNA-based vaccines

Innate Immune Recognition

2002 • 8,157 citations

A Toll-like receptor recognizes bacterial DNA

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Recognition of double-stranded RNA and activation of NF-κB by Toll-like receptor 3

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CpG motifs in bacterial DNA trigger direct B-cell activation

1995 • 3,543 citations

Recognition of single-stranded RNA viruses by Toll-like receptor 7

2004 • 1,777 citations

Human TLR9 confers responsiveness to bacterial DNA via species-specific CpG motif recognition

2001 • 1,498 citations

Innate immune recognition: mechanisms and pathways

2000 • 1,451 citations

Toll-like Receptor 9–mediated Recognition of Herpes Simplex Virus-2 by Plasmacytoid Dendritic Cells

2003 • 1,189 citations

Recognition of pathogen-associated molecular patterns by TLR family

2003 • 1,124 citations

Immunostimulatory DNA Sequences Necessary for Effective Intradermal Gene Immunization

1996 • 1,078 citations

Identification of CpG oligonucleotide sequences with high induction of IFN-α/β in plasmacytoid dendritic cells

2001 • 883 citations

Toll-like receptor expression reveals CpG DNA as a unique microbial stimulus for plasmacytoid dendritic cells which synergizes with CD40 ligand to induce high amounts of IL-12

2001 • 798 citations

Links between innate and adaptive immunity via type I interferon

2002 • 583 citations

Predominant Role for Directly Transfected Dendritic Cells in Antigen Presentation to CD8+ T Cells after Gene Gun Immunization

1998 • 569 citations

Activation of Cutaneous Dendritic Cells by CpG-Containing Oligodeoxynucleotides: A Role for Dendritic Cells in the Augmentation of Th1 Responses by Immunostimulatory DNA

1998 • 543 citations

Toll-like receptors as adjuvant receptors

2002 • 499 citations

Gene vaccination: plasmid DNA is more than just a blueprint

1998 • 359 citations

The role of CpG motifs in innate immunity

2000 • 349 citations

Bacterial CpG-DNA Triggers Activation and Maturation of Human CD11c−, CD123+ Dendritic Cells

2001 • 306 citations

Rational design of new CpG oligonucleotides that combine B cell activation with high IFN‐α induction in plasmacytoid dendritic cells

2003 • 298 citations

Regulation of Dendritic Cell Function Through Toll-Like Receptors

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CpG motifs: the active ingredient in bacterial extracts?

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Development of Th1 and Th2 Populations and the Nature of Immune Responses to Hepatitis B Virus DNA Vaccines Can Be Modulated by Codelivery of Various Cytokine Genes

1998 • 267 citations

Controlling the Toll road to dendritic cell polarization

2004 • 234 citations

Vaccination with Plasmid DNA Activates Dendritic Cells via Toll-Like Receptor 9 (TLR9) but Functions in TLR9-Deficient Mice

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Immune effects and mechanisms of action of CpG motifs

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Regulation of Dendritic Cell Function Through Toll-like Receptors

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CpG DNA redirects class‐switching towards "Th1‐like" Ig isotype production via TLR9 and MyD88

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Immunobiology of pseudorabies (Aujeszky's Disease)

1996 • 118 citations

The Preferential Induction of a Th1 Immune Response by DNA-Based Immunization Is Mediated by the Immunostimulatory Effect of Plasmid DNA

1997 • 94 citations

Co-immunization with plasmid IL-12 generates a strong T-cell memory response in mice

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Enhanced protective response and immuno-adjuvant effects of porcine GM-CSF on DNA vaccination of pigs against Aujeszky’s disease virus

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DNA vaccination of neonate piglets in the face of maternal immunity induces humoral memory and protection against a virulent pseudorabies virus challenge

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Nucleic acid vaccines: research tool or commercial reality

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Immunostimulatory effects of plasmid DNA and synthetic oligodeoxynucleotides

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Type I IFN Modulates the Immune Response Induced by DNA Vaccination to Pseudorabies Virus Glycoprotein C

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The plasmid pcDNA3 differentially induces production of interferon-α and interleukin-6 in cultures of porcine leukocytes

2001 • 28 citations

Induction of Porcine Cytokine mRNA Expression After DNA Immunization and Pseudorabies Virus Infection

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Herpes Simplex Virus Induces Appearance of Interferon-α/β-Producing Cells and Partially Interferon-α/β-Dependent Accumulation of Leukocytes in Murine Regional Lymph Nodes

1996 • 26 citations