Combined dendritic cell- and CpG oligonucleotide-based immune therapy cures large murine tumors that resist chemotherapy

A Toll-like receptor recognizes bacterial DNA

2000 • 6,348 citations

Toll-like receptors: critical proteins linking innate and acquired immunity

2001 • 4,673 citations

IFNγ and lymphocytes prevent primary tumour development and shape tumour immunogenicity

2001 • 2,658 citations

Human TLR9 confers responsiveness to bacterial DNA via species-specific CpG motif recognition

2001 • 1,498 citations

Antigen-Specific Inhibition of Effector T Cell Function in Humans after Injection of Immature Dendritic Cells

2001 • 1,384 citations

Vaccination with Mage-3a1 Peptide–Pulsed Mature, Monocyte-Derived Dendritic Cells Expands Specific Cytotoxic T Cells and Induces Regression of Some Metastases in Advanced Stage IV Melanoma

1999 • 1,260 citations

Tumor Antigens Recognized by T Lymphocytes

1994 • 1,238 citations

Identification of CpG oligonucleotide sequences with high induction of IFN-α/β in plasmacytoid dendritic cells

2001 • 883 citations

Immune and clinical responses in patients with metastatic melanoma to CD34(+) progenitor-derived dendritic cell vaccine.

2001 • 828 citations

Bacterial DNA and immunostimulatory CpG oligonucleotides trigger maturation and activation of murine dendritic cells

1998 • 809 citations

Toll-like receptor expression reveals CpG DNA as a unique microbial stimulus for plasmacytoid dendritic cells which synergizes with CD40 ligand to induce high amounts of IL-12

2001 • 798 citations

Induction of antigen-specific T cell anergy: An early event in the course of tumor progression

1998 • 710 citations

CpG DNA: A potent signal for growth, activation, and maturation of human dendritic cells

1999 • 638 citations

Mechanism and Function of a Newly Identified CpG DNA Motif in Human Primary B Cells

2000 • 604 citations

Delineation of a CpG Phosphorothioate Oligodeoxynucleotide for Activating Primate Immune Responses In Vitro and In Vivo

2000 • 593 citations

Cutting Edge: Role of Toll-Like Receptor 9 in CpG DNA-Induced Activation of Human Cells

2001 • 571 citations

The Dendritic Cell Receptor for Endocytosis, Dec-205, Can Recycle and Enhance Antigen Presentation via Major Histocompatibility Complex Class II–Positive Lysosomal Compartments

2000 • 546 citations

Activation of Cutaneous Dendritic Cells by CpG-Containing Oligodeoxynucleotides: A Role for Dendritic Cells in the Augmentation of Th1 Responses by Immunostimulatory DNA

1998 • 543 citations

Human Peripheral Blood Cells Differentially Recognize and Respond to Two Distinct CpG Motifs

2001 • 518 citations

Roles of tumour localization, second signals and cross priming in cytotoxic T-cell induction

2001 • 500 citations

Dendritic Cells as Adjuvants for Immune-mediated Resistance to Tumors

1997 • 432 citations

Coley's toxins, tumor necrosis factor and cancer research: A historical perspective

1994 • 430 citations

Generation of Tumor Immunity by Bone Marrow-Derived Dendritic Cells Correlates with Dendritic Cell Maturation Stage

1999 • 430 citations

Type I Interferon-mediated Stimulation of T Cells by CpG DNA

1998 • 361 citations

Immunoselection in vivo: Independent loss of MHC class I and melanocyte differentiation antigen expression in metastatic melanoma

1997 • 311 citations

CpG DNA induces stronger immune responses with less toxicity than other adjuvants

2000 • 264 citations

Divergent Therapeutic and Immunologic Effects of Oligodeoxynucleotides with Distinct CpG Motifs

2001 • 252 citations

Tumor-induced regulation of suppressor macrophage nitric oxide and TNF-alpha production. Role of tumor-derived IL-10, TGF-beta, and prostaglandin E2.

1994 • 244 citations

Critical Role of IL-12 in Dendritic Cell-Induced Differentiation of Naive B Lymphocytes

1998 • 214 citations

NK- and CD8+ T Cell-Mediated Eradication of Established Tumors by Peritumoral Injection of CpG-Containing Oligodeoxynucleotides

2001 • 213 citations

CpG DNA and LPS induce distinct patterns of activation in human monocytes

1999 • 210 citations

Enhanced Dendritic Cell Maturation by TNF-α or Cytidine-Phosphate-Guanosine DNA Drives T Cell Activation In Vitro and Therapeutic Anti-Tumor Immune Responses In Vivo

2000 • 195 citations

Peritumoral CpG DNA Elicits a Coordinated Response of CD8 T Cells and Innate Effectors to Cure Established Tumors in a Murine Colon Carcinoma Model

2002 • 192 citations

Oligodeoxynucleotides containing CpG motifs can induce rejection of a neuroblastoma in mice.

1999 • 188 citations

Strategies for immunotherapy of cancer

2000 • 165 citations

Repeated Administration of Cytosine-Phosphorothiolated Guanine-Containing Oligonucleotides Together with Peptide/Protein Immunization Results in Enhanced CTL Responses with Anti-Tumor Activity

2000 • 145 citations

CpG-DNA-Mediated Transient Lymphadenopathy Is Associated with a State of Th1 Predisposition to Antigen-Driven Responses

2000 • 137 citations

Successful treatment of intracranial gliomas in rat by oligodeoxynucleotides containing CpG motifs.

2000 • 135 citations

Causing a commotion in the blood: immunotherapy progresses from bacteria to bacterial DNA

2000 • 131 citations

CpG-DNA Activates In Vivo T Cell Epitope Presenting Dendritic Cells to Trigger Protective Antiviral Cytotoxic T Cell Responses

2000 • 122 citations

The immunobiology and clinical potential of immunostimulatory CpG oligodeoxynucleotides

2000 • 101 citations

Eradication of disseminated lymphomas with CpG-DNA activated T helper type 1 cells from nontransgenic mice.

2000 • 72 citations

Human monocyte-derived and CD83+ blood dendritic cells enhance NK cell-mediated cytotoxicity

2001 • 72 citations

Mature Dendritic Cells Induce T-Helper Type-1-Dominant Immune Responses in Patients with Metastatic Renal Cell Carcinoma

1999 • 68 citations

Tumor size and origin determine the antitumor activity of cisplatin or 5-fluorouracil and its modulation by leucovorin in murine colon carcinomas

1996 • 24 citations