Novel synthetic LPS receptor agonists boost systemic and mucosal antibody responses in mice

A Toll-like receptor recognizes bacterial DNA

2000 • 6,348 citations

The innate immune response to bacterial flagellin is mediated by Toll-like receptor 5

2001 • 3,507 citations

Cutting Edge: Toll-Like Receptor 4 (TLR4)-Deficient Mice Are Hyporesponsive to Lipopolysaccharide: Evidence for TLR4 as the Lps Gene Product

1999 • 3,364 citations

CD1d-Restricted and TCR-Mediated Activation of V _α 14 NKT Cells by Glycosylceramides

1997 • 2,370 citations

Toll-like Receptor-4 Mediates Lipopolysaccharide-induced Signal Transduction

1999 • 1,905 citations

Peptidoglycan- and Lipoteichoic Acid-induced Cell Activation Is Mediated by Toll-like Receptor 2

1999 • 1,714 citations

Host Defense Mechanisms Triggered by Microbial Lipoproteins Through Toll-Like Receptors

1999 • 1,679 citations

Cutting Edge: Heat Shock Protein 60 Is a Putative Endogenous Ligand of the Toll-Like Receptor-4 Complex

2000 • 1,632 citations

Cutting Edge: Recognition of Gram-Positive Bacterial Cell Wall Components by the Innate Immune System Occurs Via Toll-Like Receptor 2

1999 • 1,252 citations

Differential Expression and Regulation of Toll-Like Receptors (TLR) in Human Leukocytes: Selective Expression of TLR3 in Dendritic Cells

2000 • 1,060 citations

Recognition of a lipid antigen by CD1-restricted αβ+ T cells

1994 • 976 citations

Induction of Direct Antimicrobial Activity Through Mammalian Toll-Like Receptors

2001 • 709 citations

Regulation of Toll-Like Receptors in Human Monocytes and Dendritic Cells

2001 • 604 citations

CD40 Triggering of Heterodimeric IL-12 p70 Production by Dendritic Cells In Vivo Requires a Microbial Priming Signal

2000 • 558 citations

CD1c-mediated T-cell recognition of isoprenoid glycolipids in Mycobacterium tuberculosis infection

2000 • 440 citations

Immunologic Properties of Bacterial Lipopolysaccharide (LPS): Correlation between the Mitogenic, Adjuvant, and Immunogenic Activities

1975 • 242 citations

The adjuvant monophosphoryl lipid A increases the function of antigen-presenting cells

2000 • 179 citations

Vaccine-Containing Biodegradable Microspheres Specifically Enter the Gut-Associated Lymphoid Tissue Following Oral Administration and Induce a Disseminated Mucosal Immune Response

1989 • 132 citations

Phase I study of recombinant human tumor necrosis factor

1987 • 132 citations

Lipopolysaccharide and monophosphoryl lipid A differentially regulate interleukin-12, gamma interferon, and interleukin-10 mRNA production in murine macrophages

1997 • 132 citations

Targeting immune response induction with cochleate and liposome-based vaccines

1998 • 91 citations

Liposomal Vaccines: Clinical Status and Immunological Presentation for Humoral and Cellular Immunity

1995 • 68 citations

Interleukin-12: Role of Interferon-γ in IL-12 Adverse Effects

1997 • 63 citations

A Novel Class of Endotoxin Receptor Agonists with Simplified Structure, Toll-Like Receptor 4-Dependent Immunostimulatory Action, and Adjuvant Activity

2002 • 62 citations

A phase I trial in HIV negative healthy volunteers evaluating the effect of potent adjuvants on immunogenicity of a recombinant gp120W61D derived from dual tropic R5X4 HIV-1ACH320

2000 • 60 citations

The Enhancement of Antibody Formation by Escherichia Coli Lipopolysaccharide and Detoxified Derivatives

1969 • 50 citations

Delivery systems for molecular vaccination.

2000 • 29 citations

CpG ODN is safe and highly effective in humans as adjuvant to HBV vaccine Preliminary results of phase I trial with CpG ODN 7909

2000 • 16 citations