Mechanisms of Ammonia-Induced Astrocyte Swelling

The mitochondrial permeability transition

1995 • 2,412 citations

Early indicators of prognosis in fulminant hepatic failure

1989 • 2,064 citations

Mechanisms by which mitochondria transport calcium

1990 • 1,630 citations

Aquaporin-4 deletion in mice reduces brain edema after acute water intoxication and ischemic stroke

2000 • 1,454 citations

Fine structural localization of glutamine synthetase in astrocytes of rat brain

1979 • 1,318 citations

Neurosteroids: Endogenous bimodal modulators of the GABAA receptor mechanism of action and physiological significance

1992 • 1,098 citations

Isolation of the cDNA for erythrocyte integral membrane protein of 28 kilodaltons: member of an ancient channel family.

1991 • 795 citations

Neurosteroids and GABAA receptor function

1995 • 705 citations

Molecular characterization of an aquaporin cDNA from brain: candidate osmoreceptor and regulator of water balance.

1994 • 701 citations

The peripheral-type benzodiazepine receptor. Localization to the mitochondrial outer membrane.

1986 • 682 citations

Cerebral herniation in patients with acute E liver failure is correlated with arterial ammonia concentration

1999 • 658 citations

Glutamate Release and Free Radical Production Following Brain Injury: Effects of Posttraumatic Hypothermia

1995 • 616 citations

Oxidative Stress, Thiol Reagents, and Membrane Potential Modulate the Mitochondrial Permeability Transition by Affecting Nucleotide Binding to the Adenine Nucleotide Translocase

1997 • 588 citations

The role of cellular hydration in the regulation of cell function

1996 • 571 citations

Aquaporins in Brain: Distribution, Physiology, and Pathophysiology

2002 • 519 citations

Cyclophilin‐D binds strongly to complexes of the voltage‐dependent anion channel and the adenine nucleotide translocase to form the permeability transition pore

1998 • 475 citations

Membrane Mechanisms and Intracellular Signalling in Cell Volume Regulation

1995 • 469 citations

Hepatic encephalopathy in chronic liver disease: a clinical manifestation of astrocyte swelling and low-grade cerebral edema?

2000 • 453 citations

Peripheral-Type Benzodiazepine/Diazepam Binding Inhibitor Receptor: Biological Role in Steroidogenic Cell Function*

1993 • 404 citations

Etiology and outcome for 295 patients with acute liver failure in the united states

1999 • 396 citations

Moderate hypothermia for uncontrolled intracranial hypertension in acute liver failure

1999 • 367 citations

Mitochondrial implication in accidental and programmed cell death: apoptosis and necrosis.

1997 • 326 citations

Ammonia‐induced production of free radicals in primary cultures of rat astrocytes

2001 • 298 citations

Hepatic Encephalopathy: An Update of Pathophysiologic Mechanisms

1999 • 296 citations

Ammonia induces MK‐801‐sensitive nitration and phosphorylation of protein tyrosine residues in rat astrocytes

2002 • 283 citations

Cerebral Edema: A Major Complication of Massive Hepatic Necrosis

1971 • 272 citations

The Cytotoxicity of Tumor Necrosis Factor Depends on Induction of the Mitochondrial Permeability Transition

1996 • 266 citations

Ammonia and related amino acids in the pathogenesis of brain edema in acute ischemic liver failure in rats

1992 • 264 citations

Inhibition of brain glutamine accumulation prevents cerebral edema in hyperammonemic rats

1991 • 260 citations

Permeabilization of the inner mitochondrial membrane by Ca2+ ions is stimulated by t-butyl hydroperoxide and mediated by reactive oxygen species generated by mitochondria

1995 • 248 citations

Induction of aquaporin-4 water channel mRNA after focal cerebral ischemia in rat

2000 • 246 citations

Fulminant hepatic failure

2005 • 239 citations

Nitric oxide induces apoptosis via triggering mitochondrial permeability transition

1997 • 238 citations

Ammonia-induced brain edema and intracranial hypertension in rats after portacaval anastomosis

1994 • 236 citations

Electron microscopic study of brain capillaries in cerebral edema from fulminant hepatic failure

1992 • 222 citations

Phospholipid Degradation and Cellular Edema Induced by Free Radicals in Brain Cortical Slices

1982 • 221 citations

Superoxide Production and Antioxidant Enzymes in Ammonia Intoxication in Rats

1997 • 215 citations

Neurosteroids and GABA, receptor function

1995 • 210 citations

Inhibition of glutamine synthetase reduces ammonia-induced astrocyte swelling in rat

1996 • 209 citations

Energy Metabolism during Apoptosis

1997 • 206 citations

Differential Upregulation of Aquaporin-4 mRNA Expression in Reactive Astrocytes after Brain Injury: Potential Role in Brain Edema

1999 • 205 citations

Pathophysiology of cerebral edema in fulminant hepatic failure

1999 • 201 citations

Mitochondrial benzodiazepine receptor linked to inner membrane ion channels by nanomolar actions of ligands.

1993 • 198 citations

A light and electron microscopic study of experimental portal-systemic (ammonia) encephalopathy. Progression and reversal of the disorder.

1977 • 190 citations

The mitochondrial permeability transition

1998 • 185 citations

METABOLISM OF AMINO ACIDS AND AMMONIA IN RAT BRAIN CORTEX SLICES IN VITRO: A POSSIBLE ROLE OF AMMONIA IN BRAIN FUNCTION

1975 • 185 citations

Ammonia-induced astrocyte swelling in primary culture

1991 • 184 citations

Intracellular acidification induced by passive and active transport of ammonium ions in astrocytes

1998 • 181 citations

Macrophage and Astrocyte Populations in Relation to [³H]PK 11195 Binding in Rat Cerebral Cortex following a Local Ischaemic Lesion

1991 • 178 citations

Cerebral blood flow and the development of ammonia-induced brain edema in rats after portacaval anastomosis

1999 • 178 citations

Cyclosporin A protects against ischemia-reperfusion injury in the brain

1992 • 177 citations

Ammonia induces the mitochondrial permeability transition in primary cultures of rat astrocytes

2001 • 173 citations

Astroglial dysfunction in hepatic encephalopathy.

1998 • 169 citations

Glutamine,myo-inositol, and organic brain osmolytes after portocaval anastomosis in the rat: Implications for ammonia-induced brain edema

1996 • 167 citations

Brain microvessels: factors altering their patency after the occlusion of a middle cerebral artery (Wistar rat).

1994 • 166 citations

Total Hepatectomy and Liver Transplantation as Two-stage Procedure

1993 • 162 citations

Identification of L-methionine S-sulfoximine as the diastereoisomer of L-methionine SR-sulfoximine that inhibits glutamine synthetase

1969 • 161 citations

Changes in the Blood-Brain Barrier in Hepatic Coma After Hepatectomy in the Rat

1977 • 160 citations

Blocking NMDA receptors prevents the oxidative stress induced by acute ammonia intoxication

1999 • 159 citations

Control of cerebral oedema by total hepatectomy and extracorporeal liver support in fulminant hepatic failure

1993 • 157 citations

Postembedding immunogold labelling reveals subcellular localization and pathway-specific enrichment of phosphate activated glutaminase in rat cerebellum

1999 • 155 citations

L-Ornithine-L-aspartate lowers plasma and cerebrospinal fluid ammonia and prevents brain edema in rats with acute liver failure

1999 • 155 citations

Electron microscopic evaluation of brain edema in rabbits with galactosamine-induced fulminant hepatic failure: Ultrastructure and integrity of the blood-brain barrier

1987 • 149 citations

Alterations in the expression of the AQP family in cultured rat astrocytes during hypoxia and reoxygenation

2001 • 147 citations

EFFECT OF AN INHIBITOR OF GLUTAMINE SYNTHESIS (METHIONINE SULFOXIMINE) ON AMMONIA TOXICITY AND METABOLISM.

1964 • 146 citations

PHOSPHATE ACTIVATED GLUTAMINASE ACTIVITY AND GLUTAMINE UPTAKE IN PRIMARY CULTURES OF ASTROCYTES

1979 • 138 citations

Mild hypothermia modifies ammonia-induced brain edema in rats after portacaval anastomosis

1999 • 137 citations

Oxidative Stress in the Pathogenesis of Hepatic Encephalopathy

2004 • 136 citations

Ascorbate Inhibits Edema in Brain Slices

2000 • 136 citations

Cerebral energy metabolism in hepatic encephalopathy and hyperammonemia.

2001 • 135 citations

Liver Transplantation in Europe for Patients with Acute Liver Failure

1996 • 135 citations

Aquaporins in health and disease

2000 • 135 citations

Increased blood-brain transfer in a rabbit model of acute liver failure

1983 • 133 citations

Mild hypothermia delays the onset of coma and prevents brain edema and extracellular brain glutamate accumulation in rats with acute liver failure

2000 • 129 citations

Cerebrospinal Fluid Glutamine as a Measure of Hepatic Encephalopathy

1971 • 128 citations

Oxidative and nitrosative stress in ammonia neurotoxicity

2003 • 128 citations

Moderate hypothermia prevents cerebral hyperemia and increase in intracranial pressure in patients undergoing liver transplantation for acute liver failure

2003 • 127 citations

Brain Edema and Hepatic Encephalopathy

1996 • 124 citations

Astrocyte Swelling in Liver Failure: Role of Glutamine and Benzodiazepines

1994 • 121 citations

Cerebral hyperemia and nitric oxide synthase in rats with ammonia-induced brain edema

2001 • 119 citations

Chronic hyponatremia exacerbates ammonia-induced brain edema in rats after portacaval anastomosis

1998 • 119 citations

Glutamine‐induced free radical production in cultured astrocytes

2004 • 118 citations

Chapter 10: Do astrocytes process neural information?

1992 • 116 citations

The inhibition in vivo of cerebral glutamine synthetase and glutamine transferase by the convulsant methionine sulfoximine

1965 • 111 citations

Acute Hyperammonemia in the Young Primate: Physiologic and Neuropathologic Correlates

1983 • 110 citations

Liver derived pro-inflammatory cytokines may be important in producing intracranial hypertension in acute liver failure

2002 • 109 citations

Changes in brain metabolism during hyperammonemia and acute liver failure: Results of a comparative1H-NMR spectroscopy and biochemical investigation

1990 • 109 citations

Effect ofN-Acetylcysteine on Mitochondrial Function Following Traumatic Brain Injury in Rats

1999 • 109 citations

Increased aquaporin-4 expression in ammonia-treated cultured astrocytes

2003 • 107 citations

Properties of phosphate activated glutaminase in astrocytes cultured from mouse brain

1982 • 107 citations

Characterization of the peripheral‐type benzodiazepine receptors in cultured astrocytes: Evidence for multiplicity

1993 • 106 citations

Observation of Cerebral Metabolites in an Animal Model of Acute Liver Failure In Vivo: A ¹H and ³¹P Nuclear Magnetic Resonance Study

1989 • 102 citations

Glutamate Metabolism in Rat Cortical Astrocyte Cultures

1992 • 98 citations

Swelling, Acidosis, and Irreversible Damage of Glial Cells from Exposure to Arachidonic Acid in vitro

1994 • 98 citations

Peripheral-type benzodiazepine receptors

1993 • 96 citations

Nitroarginine, an inhibitor of nitric oxide synthase, prevents changes in superoxide radical and antioxidant enzymes induced by ammonia intoxication.

1998 • 93 citations

Effect of benzodiazepines and neurosteroids on ammonia-induced swelling in cultured astrocytes

1998 • 92 citations

Indomethacin normalizes intracranial pressure in acute liver failure: A twenty-three-year-old woman treated with indomethacin

1997 • 91 citations

Colon cancer connections. Cancer syndrome meets molecular biology meets histopathology.

1994 • 90 citations

Role of oxidative stress in the ammonia-induced mitochondrial permeability transition in cultured astrocytes

2005 • 90 citations

Induction of the mitochondrial permeability transition in cultured astrocytes by glutamine

2003 • 89 citations

Potential role of cerebral glutathione in the maintenance of blood-brain barrier integrity in rat.

1999 • 88 citations

Indications for orthotopic liver transplantation in fulminant liver failure

1994 • 88 citations

Nitroarginine, an inhibitor of nitric oxide synthetase, attenuates ammonia toxicity and ammonia-induced alterations in brain metabolism

1995 • 86 citations

Swelling of astrocytes causes membrane potential depolarization

1988 • 84 citations

Alterations to glutathione and nicotinamide nucleotides during the mitochondrial permeability transition induced by peroxynitrite

1996 • 82 citations

Role of glutamine in cerebral nitrogen metabolism and ammonia neurotoxicity

2001 • 81 citations

Electron microscopy in human hepatic encephalopathy

1968 • 81 citations

Increased neuronal nitric oxide synthase expression in brain following portacaval anastomosis

1997 • 80 citations

Effects on free radical generation by ligands of the peripheral benzodiazepine receptor in cultured neural cells

2002 • 79 citations

The Peripheral Benzodiazepine Receptor and Neurosteroids in Hepatic Encephalopathy

1997 • 78 citations

Increased Nitric Oxide Synthase Activities and <scp>l</scp>‐[³H]Arginine Uptake in Brain Following Portacaval Anastomosis

1995 • 77 citations

GeneChip® analysis shows altered mRNA expression of transcripts of neurotransmitter and signal transduction pathways in the cerebral cortex of portacaval shunted rats

2002 • 77 citations

Peripheral-type benzodiazepine/diazepam binding inhibitor receptor: biological role in steroidogenic cell function

1993 • 76 citations

Ammonia Neurotoxicity and the Mitochondrial Permeability Transition

2004 • 74 citations

Physiological Levels of Ammonia Regulate Glutamine Synthesis from Extracellular Glutamate in Astrocyte Cultures

1992 • 73 citations

Lactic acid-induced swelling in C6 glial cells via Na+/H+ exchange

1989 • 72 citations

Excitotoxic mechanism of cell swelling in rat cerebral cortical slices treated acutely with ammonia

2003 • 71 citations

Suppression of ammonia‐induced astrocyte swelling by cyclosporin A

2003 • 71 citations

Ammonia‐induced heme oxygenase‐1 expression in cultured rat astrocytes and rat brain in vivo

2002 • 70 citations

Swelling-Activated Release of Excitatory Amino Acids in the Brain: Relevance for Pathophysiology

1998 • 69 citations

Cerebral metabolic and histological effects of thioacetamide-induced liver failure

1993 • 69 citations

Characterization of peripheral benzodiazepine type sites in a cultured murine BV-2 microglial cell line

1996 • 68 citations

Methionine Sulfoximine, a Glutamine Synthetase Inhibitor, Attenuates Increased Extracellular Potassium Activity during Acute Hyperammonemia

1997 • 68 citations

Proton‐Decoupled ³¹P Magnetic Resonance Spectroscopy Reveals Osmotic and Metabolic Disturbances in Human Hepatic Encephalopathy

1998 • 66 citations

EFFECTS OF AMMONIUM IONS ON SPONTANEOUS ACTION POTENTIALS AND ON CONTENTS OF SODIUM, POTASSIUM, AMMONIUM AND CHLORIDE IONS IN BRAIN IN VITRO

1978 • 65 citations

The astrocytic (“peripheral-type”) benzodiazepine receptor: role in the pathogenesis of portal-systemic encephalopathy

2000 • 62 citations

Experimental ammonia encephalopathy in the primate.

1970 • 61 citations

Selective alterations of brain osmolytes in acute liver failure: protective effect of mild hypothermia

2003 • 59 citations

Effects of Ammonia Exposition on Glioma Cells: Changes in Cell Volume and Organic Osmolytes Studied by Diffusion-Weighted and High-Resolution NMR Spectroscopy

2000 • 58 citations

Restoration of cerebrovascular CO2 responsivity by glutamine synthesis inhibition in hyperammonemic rats.

1992 • 58 citations

Control of hepatic nitrogen metabolism and glutathione release by cell volume regulatory mechanisms

1990 • 57 citations

N-Acetylcysteine protects against age-related increase in oxidized proteins in mouse synaptic mitochondria

1997 • 57 citations

Experimental Ammonia Encephalopathy in the Primate

1972 • 56 citations

Isolation and Functional Analysis of Alternative Promoters in the Human Aquaporin-4 Water Channel Gene

1998 • 55 citations

Ammonia and manganese increase arginine uptake in cultured astrocytes.

1998 • 54 citations

Increased cerebrospinal fluid lactate reflects deterioration of neurological status in experimental portal-systemic encephalopathy

1991 • 52 citations

Elevation of glutathione levels by ammonium ions in primary cultures of rat astrocytes

2000 • 52 citations

Histochemistry of glutamate metabolizing enzymes in the rat cerebellar cortex

1991 • 51 citations

The inflammatory basis of intracranial hypertension in acute liver failure

2001 • 48 citations

Effect of ammonium chloride on energy metabolism of astrocytes and C6-glioma cellsin vitro

1997 • 47 citations

Cerebrospinal Fluid Lactate in Patients with Hepatic Encephalopathy

1987 • 46 citations

Fulminant hepatic failure

1991 • 44 citations

Role of antioxidants and scavengers on argemone oil-induced toxicity in rats

1991 • 42 citations

New Roles of Carnitine Metabolism in Ammonia Cytotoxicity

1990 • 40 citations

Swelling of glial cells in lactacidosis and by glutamate: significance of Cl—-transport

1993 • 40 citations

FACTORS ASSOCIATED WITH SEVERE INTRACRANIAL HYPERTENSION IN CANDIDATES FOR EMERGENCY LIVER TRANSPLANTATION

1993 • 40 citations

Isolation of astrocytes, neurons, and synaptosomes of rat brain cortex

1985 • 39 citations

Cerebrospinal fluid amino acids in relation to neurological status in experimental portal-systemic encephalopathy

1991 • 39 citations

Effects of chronic exposure to ammonia on glutamate and glutamine interconversion and compartmentation in homogeneous primary cultures of mouse astrocytes

1994 • 38 citations

Hydroxyl radical scavenging and antipsoriatic activity of benzoic acid derivatives

1990 • 35 citations

The Role of Arachidonic Acid and Oxygen Radical Metabolites in the Pathogenesis of Vasogenic Brain Edema and Astrocytic Swellinga

1989 • 34 citations

Binding of [3H]Ro 5–4864 in primary cultures of astrocytes

1985 • 33 citations

Differential response of glutamine in cultured neurons and astrocytes

2004 • 33 citations

Expression of aquaporins in Xenopus laevis oocytes and glial cells as detected by diffusion-weighted 1H NMR spectroscopy and photometric swelling assay

1998 • 24 citations

Depletion of glutathione from brain cells in hyponatremia

1996 • 22 citations

Cerebrospinal fluid glutamine as a measure of hepatic encephalopathy

1971 • 18 citations

Ammonia-induced brain edema and intracranial hypertension in rats after portacaval anastomosis

1994 • 15 citations

Correlations between energy metabolism, ion transport, and water content in astrocytes

1992 • 15 citations

Ammonia-induced alterations in the metabolism of glutamate and aspartate in neuronal perikarya and synaptosomes of rat cerebellum

1992 • 11 citations

Inhibition of [3H]diazepam binding in primary cultures of astrocytes by atrial natriuretic peptide and by a cyclic GMP analog

1987 • 10 citations

Study of the hypothermia induced by methionine sulfoximine in the rat

1988 • 7 citations

Cerebral edema and intracranial hypertension in acute liver failure: Distinct aspects of the same problem

1991 • 6 citations

Untitled

1997 • 3 citations

Deleted Work

1955 • 0 citations