Nitric oxide‐induced programmed cell death in human neuroblastoma cells is accompanied by the synthesis of Egr‐1, a zinc finger transcription factor

Redox signaling: Nitrosylation and related target interactions of nitric oxide

1994 • 1,732 citations

NO at work

1994 • 1,493 citations

The SRF accessory protein Elk-1 contains a growth factor-regulated transcriptional activation domain

1993 • 1,313 citations

A zinc finger-encoding gene coregulated with c-fos during growth and differentiation, and after cellular depolarization

1988 • 1,278 citations

c-Jun dimerizes with itself and with c-Fos, forming complexes of different DNA binding affinities

1988 • 1,084 citations

Inhibitors of protein synthesis and RNA synthesis prevent neuronal death caused by nerve growth factor deprivation.

1988 • 909 citations

Altered gene expression in neurons during programmed cell death: identification of c-jun as necessary for neuronal apoptosis.

1994 • 820 citations

Continuous c-fos expression precedes programmed cell death in vivo

1993 • 784 citations

Nitric Oxide as a Bioregulator of Apoptosis

2001 • 535 citations

Induction of c-fos expression through JNK-mediated TCF/Elk-1 phosphorylation.

1995 • 535 citations

Nitric oxide and the regulation of gene expression

2001 • 529 citations

Fos and Jun bind cooperatively to the AP-1 site: reconstitution in vitro.

1988 • 511 citations

Nitric oxide produced by human B lymphocytes inhibits apoptosis and Epstein-Barr virus reactivation

1994 • 509 citations

Role of p38 and JNK Mitogen-Activated Protein Kinases in the Activation of Ternary Complex Factors

1997 • 467 citations

Expressing the human genome

2001 • 407 citations

p38 Map Kinase Mediates Bax Translocation in Nitric Oxide–Induced Apoptosis in Neurons

2000 • 391 citations

Heterodimer formation of cJun and ATF-2 is responsible for induction of c-jun by the 243 amino acid adenovirus E1A protein.

1993 • 380 citations

Journey to the surface of the cell: Fos regulation and the SRE.

1995 • 376 citations

NAB2, a Corepressor of NGFI-A (Egr-1) and Krox20, Is Induced by Proliferative and Differentiative Stimuli

1996 • 353 citations

Splenic B lymphocyte programmed cell death is prevented by nitric oxide release through mechanisms involving sustained Bcl-2 levels.

1995 • 340 citations

Concentration-dependent Effects of Nitric Oxide on Mitochondrial Permeability Transition and Cytochrome cRelease

2000 • 326 citations

A molecular basis for nitric oxide sensing by soluble guanylate cyclase

1999 • 316 citations

Nitric oxide (NO): an effector of apoptosis

1999 • 298 citations

Peroxynitrite‐Induced Cytotoxicity in PC12 Cells: Evidence for an Apoptotic Mechanism Differentially Modulated by Neurotrophic Factors

1995 • 292 citations

Nitric oxide-induced apoptosis: p53-dependent and p53-independent signalling pathways

1996 • 284 citations

Different requirements for formation of Jun: Jun and Jun: Fos complexes.

1989 • 272 citations

Aggregated Amyloid-β Protein Induces Cortical Neuronal Apoptosis and Concomitant “Apoptotic” Pattern of Gene Induction

1997 • 261 citations

Identification of NAB1, a repressor of NGFI-A- and Krox20-mediated transcription.

1995 • 258 citations

Nitric oxide negatively regulates c-Jun N-terminal kinase/stress-activated protein kinase by means ofS-nitrosylation

2000 • 244 citations

Akt Activation Protects Hippocampal Neurons from Apoptosis by Inhibiting Transcriptional Activity of p53

2001 • 243 citations

c-Jun and the transcriptional control of neuronal apoptosis

2000 • 241 citations

Interactive effects of nitric oxide and the p53 tumor suppressor gene in carcinogenesis and tumor progression

1997 • 234 citations

Suppression of growth and transformation and induction of apoptosis by EGR-1.

1998 • 219 citations

Stimulation of the Cyclic GMP Pathway by NO Induces Expression of the Immediate Early Genes c‐fos and junB in PC12 Cells

1994 • 187 citations

Early Growth Response-1-dependent Apoptosis Is Mediated by p53

1997 • 172 citations

In VivoExpression and Regulation of Elk-1, a Target of the Extracellular-Regulated Kinase Signaling Pathway, in the Adult Rat Brain

1998 • 155 citations

Peroxynitrite and Nitric Oxide Donors Induce Neuronal Apoptosis by Eliciting Autocrine Excitotoxicity

1997 • 147 citations

Mechanisms of Nitric Oxide-Dependent Apoptosis: Involvement of Mitochondrial Mediators

1999 • 128 citations

Caspase Activation Accompanying Cytochrome c Release from Mitochondria Is Possibly Involved in Nitric Oxide‐Induced Neuronal Apoptosis in SH‐SY5Y Cells

1999 • 119 citations

Role of EGR-1 in Thapsigargin-Inducible Apoptosis in the Melanoma Cell Line A375-C6

1995 • 107 citations

The human transcriptional repressor protein NAB1: expression and biological activity

2000 • 105 citations

Inhibition of protein synthesis prevents cell death in sensory and parasympathetic neurons deprived of neurotrophic factor in vitro

1990 • 103 citations

Cu,Zn-Superoxide Dismutase-dependent Apoptosis Induced by Nitric Oxide in Neuronal Cells

2000 • 102 citations

Complex Functions of AP-1 Transcription Factors in Differentiation and Survival of PC12 Cells

2001 • 92 citations

Characterization of tissue-specific transcription by the human synapsin I gene promoter.

1991 • 87 citations

Ionizing Radiation-inducible Apoptosis in the Absence of p53 Linked to Transcription Factor EGR-1

1997 • 86 citations

A Fos protein containing the Jun leucine zipper forms a homodimer which binds to the AP1 binding site

1989 • 77 citations

Zinc Finger Transcription Factors as Molecular Targets for Nitric Oxide-mediated Immunosuppression: Inhibition of IL-2 Gene Expression in Murine Lymphocytes

1999 • 75 citations

Mechanism of nitric oxide‐induced apoptosis in human neuroblastoma SH‐SY5Y cells

2000 • 71 citations

Regulation and composition of activator protein 1 (AP-1) transcription factors controlling collagenase and c-Jun promoter activities

2001 • 65 citations

The Extracellular Signal-Regulated Protein Kinases Erk1/Erk2 Stimulate Expression and Biological Activity of the Transcriptional Regulator Egr-1

2001 • 60 citations

Differential Regulation of Chromogranin B and Synapsin I Gene Promoter Activity by cAMP and cAMP‐Dependent Protein Kinase

1994 • 58 citations

Rapid Attenuation of AP-1 Transcriptional Factors Associated with Nitric Oxide (NO)-mediated Neuronal Cell Death

1996 • 56 citations

MDM2 Mediated Nuclear Exclusion of p53 Attenuates Etoposide-Induced Apoptosis in Neuroblastoma Cells

2001 • 56 citations

Nitric Oxide Modulates the c-Jun N-terminal Kinase/Stress-Activated Protein Kinase Activity through Activating c-Jun N-Terminal Kinase Kinase

1997 • 53 citations

Nerve growth factor- and epidermal growth factor-regulated gene transcription in PC12 pheochromocytoma and INS-1 insulinoma cells

2000 • 50 citations

Molecular kinetics of beef heart lactate dehydrogenase

1974 • 46 citations

Regulation and composition of activator protein 1 (AP-1) transcription factors controlling collagenase and c-Jun promoter activities

2001 • 46 citations

An enhanced expression of the immediate early gene, Egr-1, is associated with neuronal apoptosis in culture

1999 • 36 citations

Nitric oxide donor-induced p53-sensitive cell death is enhanced by Bcl-2 reduction in human neuroblastoma cells

1998 • 29 citations