The Extracellular Signal-Regulated Protein Kinases Erk1/Erk2 Stimulate Expression and Biological Activity of the Transcriptional Regulator Egr-1

Transformation of Mammalian Cells by Constitutively Active MAP Kinase Kinase

1994 • 1,370 citations

A zinc finger-encoding gene coregulated with c-fos during growth and differentiation, and after cellular depolarization

1988 • 1,278 citations

A Nerve Growth Factor-Induced Gene Encodes a Possible Transcriptional Regulatory Factor

1987 • 1,217 citations

MKP-1 (3CH134), an immediate early gene product, is a dual specificity phosphatase that dephosphorylates MAP kinase in vivo

1993 • 1,169 citations

Integration of MAP Kinase Signal Transduction Pathways at the Serum Response Element

1995 • 935 citations

A requirement for the immediate early gene Zif268 in the expression of late LTP and long-term memories

2001 • 882 citations

A gene activated in mouse 3T3 cells by serum growth factors encodes a protein with "zinc finger" sequences.

1988 • 733 citations

Early Growth Response Protein 1 (Egr-1): Prototype of a Zinc-finger Family of Transcription Factors

1995 • 593 citations

Identification of the sites in MAP kinase kinase-1 phosphorylated by p74raf-1.

1994 • 551 citations

Egr-1-Induced Endothelial Gene Expression: A Common Theme in Vascular Injury

1996 • 525 citations

Luteinizing Hormone Deficiency and Female Infertility in Mice Lacking the Transcription Factor NGFI-A (Egr-1)

1996 • 479 citations

Activation of MEK family kinases requires phosphorylation of two conserved Ser/Thr residues.

1994 • 388 citations

NAB2, a Corepressor of NGFI-A (Egr-1) and Krox20, Is Induced by Proliferative and Differentiative Stimuli

1996 • 353 citations

Identification of NAB1, a repressor of NGFI-A- and Krox20-mediated transcription.

1995 • 258 citations

Growth Hormone Stimulates Phosphorylation and Activation of Elk-1 and Expression of c-fos, egr-1, and junB through Activation of Extracellular Signal-regulated Kinases 1 and 2

1998 • 256 citations

Induction of Apoptosis by Pyrrolidinedithiocarbamate and N-Acetylcysteine in Vascular Smooth Muscle Cells

1996 • 248 citations

Regulation of synapsin I gene expression by the zinc finger transcription factor zif268/egr-1.

1994 • 203 citations

Human T-cell mitogen-activated protein kinase kinases are related to yeast signal transduction kinases.

1992 • 202 citations

Egr-1 Activates Basic Fibroblast Growth Factor Transcription

1996 • 197 citations

Functional serum response elements upstream of the growth factor-inducible gene zif268.

1989 • 180 citations

Identification and characterization of a new mammalian mitogen-activated protein kinase kinase, MKK2.

1993 • 152 citations

Early growth response factor 1: a pleiotropic mediator of inducible gene expression

1998 • 106 citations

The human transcriptional repressor protein NAB1: expression and biological activity

2000 • 105 citations

Characterization of tissue-specific transcription by the human synapsin I gene promoter.

1991 • 87 citations

Protein phosphatase inhibitors induce the sustained expression of the Egr-1 gene and the hyperphosphorylation of its gene product.

1992 • 70 citations

NGFI-A gene expression is necessary for T lymphocyte proliferation.

1993 • 61 citations

Transcription Factor Egr-1 Regulates Glomerular Mesangial Cell Proliferation

1996 • 61 citations

Nerve growth factor- and epidermal growth factor-regulated gene transcription in PC12 pheochromocytoma and INS-1 insulinoma cells

2000 • 50 citations

Induction of Early Growth Response-1 Gene Expression by Calmodulin Antagonist Trifluoperazine through the Activation of Elk-1 in Human Fibrosarcoma HT1080 Cells

2001 • 38 citations