CD28/CTLA-4 receptor structure, binding stoichiometry and aggregation during T-cell activation

Signal transduction by receptors with tyrosine kinase activity

1990 • 5,528 citations

Structure of the human class I histocompatibility antigen, HLA-A2

1987 • 3,453 citations

The Immunoglobulin Superfamily—Domains for Cell Surface Recognition

1988 • 2,237 citations

Human Growth Hormone and Extracellular Domain of Its Receptor: Crystal Structure of the Complex

1992 • 2,236 citations

CTLA-4 can function as a negative regulator of T cell activation

1994 • 2,107 citations

CTLA-4 is a second receptor for the B cell activation antigen B7.

1991 • 1,662 citations

Crystal structure of the human class II MHC protein HLA-DR1 complexed with an influenza virus peptide

1994 • 1,553 citations

The B7 and CD28 receptor families

1994 • 1,342 citations

The Role of the CD28 Receptor During T Cell Responses to Antigen

1993 • 1,320 citations

Costimulation of T lymphocytes: the role of CD28, CTLA-4, and B7/BB1 in interleukin-2 production and immunotherapy

1992 • 1,290 citations

Human B7-1 (CD80) and B7-2 (CD86) bind with similar avidities but distinct kinetics to CD28 and CTLA-4 receptors

1994 • 950 citations

Dimerization of the Extracellular Domain of the Human Growth Hormone Receptor by a Single Hormone Molecule

1991 • 879 citations

Anatomy of the antibody molecule

1994 • 868 citations

Immunosuppression in Vivo by a Soluble Form of the CTLA-4 T Cell Activation Molecule

1992 • 820 citations

Treatment of Murine Lupus with CTLA4Ig

1994 • 683 citations

The Immunoglobulin Fold

1994 • 679 citations

Heparin-induced oligomerization of FGF molecules is responsible for FGF receptor dimerization, activation, and cell proliferation

1994 • 665 citations

Partial T cell signaling: Altered phospho-? and lack of zap70 recruitment in APL-induced T cell anergy

1994 • 608 citations

Two Classes of PDGF Receptor Eecognize Different Isoforms of PDGF

1988 • 603 citations

Coexpression and functional cooperation of CTLA-4 and CD28 on activated T lymphocytes.

1992 • 592 citations

T-cell activation by the CD28 ligand B7 is required for cardiac allograft rejection in vivo.

1992 • 558 citations

Atomic structure of a fragment of human CD4 containing two immunoglobulin-like domains

1990 • 549 citations

Crystal structure of an HIV-binding recombinant fragment of human CD4

1990 • 545 citations

Regulation of signal transduction and signal diversity by receptor oligomerization

1994 • 485 citations

Many of the Immunoglobulin Superfamily Domains in Cell Adhesion Molecules and Surface Receptors Belong to a New Structural Set Which is close to That Containing Variable Domains

1994 • 439 citations

Solution Structure of the Epithelial Cadherin Domain Responsible for Selective Cell Adhesion

1995 • 414 citations

Signal transduction by allosteric receptor oligomerization

1988 • 410 citations

The Immunoglobulin Fold Structural Classification, Sequence Patterns and Common Core

1994 • 408 citations

The X-ray structure of a growth hormone–prolactin receptor complex

1994 • 390 citations

Binding of phosphatidyl-inositol-3-OH kinase to CD28 is required for T-cell signalling

1994 • 378 citations

Dimerization of B-type Platelet-derived Growth Factor Receptors Occurs After Ligand Binding and Is Closely Associated with Receptor Kinase Activation

1989 • 366 citations

TRANSPLANTATION TOLERANCE INDUCED BY CTLA4-Ig1

1994 • 303 citations

Crystal structure at 2.8 Å resolution of a soluble form of the cell adhesion molecule CD2

1992 • 295 citations

TRANSPLANTATION TOLERANCE INDUCED BY CTLA4-Ig1

1994 • 294 citations

T Cell Receptor-MHC Class I Peptide Interactions: Affinity, Kinetics, and Specificity

1994 • 292 citations

T-cell antigen CD28 interacts with the lipid kinase phosphatidylinositol 3-kinase by a cytoplasmic Tyr(P)-Met-Xaa-Met motif.

1994 • 291 citations

Human T cell activation. II. A new activation pathway used by a major T cell population via a disulfide-bonded dimer of a 44 kilodalton polypeptide (9.3 antigen).

1985 • 285 citations

Crystal structure of a soluble form of the human T cell coreceptor CD8 at 2.6 Å resolution

1992 • 268 citations

Transmembrane signaling: the joy of aggregation.

1992 • 267 citations

Three-Dimensional Structure of Antibodies

1988 • 256 citations

Complementarity determining region 1 (CDR1)- and CDR3-analogous regions in CTLA-4 and CD28 determine the binding to B7-1.

1994 • 236 citations

CD28 is associated with and induces the immediate tyrosine phosphorylation and activation of the Tec family kinase ITK/EMT in the human Jurkat leukemic T-cell line.

1994 • 232 citations

Intercellular Communication and Cell-Cell Adhesio n

1992 • 230 citations

Crosslinking of surface antigens causes mobilization of intracellular ionized calcium in T lymphocytes.

1987 • 228 citations

Affinity Maturation of Human Growth Hormone by Monovalent Phage Display

1993 • 227 citations

Molecular associations between the T-lymphocyte antigen receptor complex and the surface antigens CD2, CD4, or CD8 and CD5.

1992 • 226 citations

Antibodies to Tp67 and Tp44 augment and sustain proliferative responses of activated T cells.

1985 • 218 citations

Crystal structure of the extracellular region of human tissue factor

1994 • 218 citations

Human Cell-Adhesion Molecule CD2 Binds CD58 (LFA-3) with a Very Low Affinity and an Extremely Fast Dissociation Rate but Does Not Bind CD48 or CD59

1994 • 204 citations

A 44 kilodalton cell surface homodimer regulates interleukin 2 production by activated human T lymphocytes.

1986 • 191 citations

Ligand-induced dimerization of the platelet-derived growth factor receptor

1989 • 190 citations

Crystal structure of an integrin-binding fragment of vascular cell adhesion molecule-1 at 1.8 Å resolution

1995 • 187 citations

Stimulation of CD28 triggers an association between CD28 and phosphatidylinositol 3-kinase in Jurkat T cells.

1994 • 183 citations

CD28 ligation in T-cell activation: evidence for two signal transduction pathways

1990 • 173 citations

The role of p21ras in CD28 signal transduction: triggering of CD28 with antibodies, but not the ligand B7-1, activates p21ras.

1994 • 169 citations

Expression and function of B7 on human epidermal Langerhans cells.

1993 • 166 citations

Antibody binding to CD5 (Tp67) and Tp44 T cell surface molecules: effects on cyclic nucleotides, cytoplasmic free calcium, and cAMP-mediated suppression.

1986 • 166 citations

The biophysics of ligand–receptor interactions

1980 • 150 citations

The cytoplasmic domain of CD28 is both necessary and sufficient for costimulation of interleukin-2 secretion and association with phosphatidylinositol 3'-kinase.

1994 • 145 citations

Crystal Structure of Domains 3 and 4 of Rat CD4: Relation to the NH₂-Terminal Domains

1993 • 142 citations

Involvement of T44 molecules in an antigen-independent pathway of T cell activation. Analysis of the correlations to the T cell antigen-receptor complex.

1985 • 142 citations

Structure of domain 1 of rat T lymphocyte CD2 antigen

1991 • 142 citations

Knowledge‐based model building of proteins: Concepts and examples

1993 • 116 citations

Antibody structure

1993 • 102 citations

Costimulation of T lymphocytes with integrin ligands intercellular adhesion molecule-1 or vascular cell adhesion molecule-1 induces functional expression of CTLA-4, a second receptor for B7.

1994 • 93 citations

CD28-induced T cell activation. Evidence for a protein-tyrosine kinase signal transduction pathway.

1992 • 92 citations

A 45‐kDa human T‐cell membrane glycoprotein functions in the regulation of cell proliferative responses

1984 • 84 citations

Intrasubunit Signal Transduction by the Aspartate Chemoreceptor

1991 • 82 citations

The CD58 (LFA-3) binding site is a localized and highly charged surface area on the AGFCC'C" face of the human CD2 adhesion domain.

1993 • 81 citations

Activation-dependent phosphorylation of the T-lymphocyte surface receptor CD28 and associated proteins.

1994 • 81 citations

Delineation of an extended surface contact area on human CD4 involved in class II major histocompatibility complex binding.

1993 • 74 citations

Differential regulatory signals delivered by antibody binding to the CD28 (Tp44) molecule during the activation of human T lymphocytes.

1988 • 68 citations

T90/44 (9.3 antigen). A cell surface molecule with a function in human T cell activation

1986 • 60 citations

Activation of src Family Kinase lck Following CD28 Crosslinking in the Jurkat Leukemic Cell Line

1994 • 59 citations

The role of charge and multiple faces of the CD8alpha/alpha homodimer in binding to major histocompatibility complex class Imolecules: support for a bivalent model.

1994 • 51 citations

Immunoglobulin fold characteristics of B7–1 (CD80) and B7–2 (CD86)

1994 • 33 citations

CD28 cross-linking augments TCR-mediated signals and costimulates superantigen responses.

1995 • 33 citations

Ligand binding properties of the human erythropoietin receptor extracellular domain expressed in Escherichia coli.

1992 • 29 citations

CD28 Receptor Crosslinking Induces Tyrosine Phosphorylation of PLCγ1

1992 • 24 citations