Human Cell-Adhesion Molecule CD2 Binds CD58 (LFA-3) with a Very Low Affinity and an Extremely Fast Dissociation Rate but Does Not Bind CD48 or CD59

Integrins: Versatility, modulation, and signaling in cell adhesion

1992 • 9,986 citations

Adhesion receptors of the immune system

1990 • 6,585 citations

Models for the Specific Adhesion of Cells to Cells

1978 • 4,159 citations

Leukocytes roll on a selectin at physiologic flow rates: Distinction from and prerequisite for adhesion through integrins

1991 • 2,195 citations

T-cell receptor cross-linking transiently stimulates adhesiveness through LFA-1

1989 • 1,587 citations

Immobilization of proteins to a carboxymethyldextran-modified gold surface for biospecific interaction analysis in surface plasmon resonance sensors

1991 • 1,263 citations

Selectins: Interpreters of Cell-Specific Carbohydrate Information During Inflammation

1992 • 1,255 citations

The Lymphocyte Function Associated LFA-1, CD2, and LFA-3 Molecules: Cell Adhesion Receptors of the Immune System

1987 • 1,104 citations

Kinetic analysis of monoclonal antibody-antigen interactions with a new biosensor based analytical system

1991 • 1,071 citations

Quantitative determination of surface concentration of protein with surface plasmon resonance using radiolabeled proteins

1991 • 1,037 citations

Two-step model of leukocyte-endothelial cell interaction in inflammation: distinct roles for LECAM-1 and the leukocyte beta 2 integrins in vivo.

1991 • 977 citations

Molecular cloning of the CD2 antigen, the T-cell erythrocyte receptor, by a rapid immunoselection procedure.

1987 • 949 citations

Real-time biospecific interaction analysis using surface plasmon resonance and a sensor chip technology.

1991 • 909 citations

Three distinct antigens associated with human T-lymphocyte-mediated cytolysis: LFA-1, LFA-2, and LFA-3.

1982 • 740 citations

Expression cloning of a functional glycoprotein ligand for P-selectin

1993 • 734 citations

An LFA-3 cDNA encodes a phospholipid-linked membrane protein homologous to its receptor CD2

1987 • 699 citations

An endothelial ligand for L-Selectin is a novel mucin-like molecule

1992 • 660 citations

CD59, an LY-6-like protein expressed in human lymphoid cells, regulates the action of the complement membrane attack complex on homologous cells.

1989 • 640 citations

Binding of L-Selectin to the Vascular Sialomucin CD34

1993 • 629 citations

The neutrophil selectin LECAM-1 presents carbohydrate ligands to the vascular selectins ELAM-1 and GMP-140

1991 • 592 citations

The kinetics of antibody binding to membrane antigens in solution and at the cell surface

1980 • 568 citations

L-selectin-mediated lymphocyte rolling on MAdCAM-1

1993 • 540 citations

Role of Lymphocyte Adhesion Receptors in Transient Interactions and Cell Locomotion

1991 • 532 citations

The T lymphocyte glycoprotein CD2 binds the cell surface ligand LFA-3

1987 • 453 citations

Chemotactic factors regulate lectin adhesion molecule 1 (LECAM-1)-dependent neutrophil adhesion to cytokine-stimulated endothelial cells in vitro.

1991 • 439 citations

Neutrophils roll on E-selectin.

1993 • 339 citations

Structural and functional characterization of monomeric soluble P-selectin and comparison with membrane P-selectin

1993 • 297 citations

Crystal structure at 2.8 Å resolution of a soluble form of the cell adhesion molecule CD2

1992 • 295 citations

Purified lymphocyte function-associated antigen 3 binds to CD2 and mediates T lymphocyte adhesion.

1987 • 259 citations

Immobilization chemistries suitable for use in the BIAcore surface plasmon resonance detector

1992 • 247 citations

CD48 is a counter-receptor for mouse CD2 and is involved in T cell activation.

1992 • 220 citations

Relationship between the velocity of rolling granulocytes and that of the blood flow in venules

1973 • 205 citations

Direct evidence for two affinity states for lymphocyte function-associated antigen 1 on activated T cells.

1993 • 195 citations

Detection and spatial distribution of the beta 2 integrin (Mac-1) and L-selectin (LECAM-1) adherence receptors on human neutrophils by high-resolution field emission SEM.

1993 • 195 citations

Analysis of macromolecular interactions using immobilized ligands

1992 • 181 citations

Specific interaction of lymphocyte function-associated antigen 3 with CD2 can inhibit T cell responses.

1993 • 180 citations

SH2 domains exhibit high-affinity binding to tyrosine-phosphorylated peptides yet also exhibit rapid dissociation and exchange.

1993 • 177 citations

Overlapping but Nonidentical Binding Sites on CD2 for CD58 and a Second Ligand CD59

1992 • 165 citations

Peptide and nucleotide sequences of rat CD4 (W3/25) antigen: evidence for derivation from a structure with four immunoglobulin-related domains.

1987 • 157 citations

The Structural Biology of CD2

1989 • 154 citations

Interactions between SH2 domains and tyrosine-phosphorylated platelet-derived growth factor beta-receptor sequences: analysis of kinetic parameters by a novel biosensor-based approach.

1993 • 154 citations

Monoclonal antibody and ligand binding sites of the T cell erythrocyte receptor (CD2)

1987 • 143 citations

Expression of a class II major histocompatibility complex (MHC) heterodimer in a lipid-linked form with enhanced peptide/soluble MHC complex formation at low pH.

1991 • 143 citations

Structure of domain 1 of rat T lymphocyte CD2 antigen

1991 • 142 citations

How do selectins mediate leukocyte rolling in venules?

1992 • 138 citations

Primary structure of lymphocyte function-associated antigen 3 (LFA-3). The ligand of the T lymphocyte CD2 glycoprotein.

1987 • 135 citations

Characterization of a broadly expressed human leucocyte surface antigen MEM-43 anchored in membrane through phosphatidylinositol

1989 • 135 citations

A soluble multimeric recombinant CD2 protein identifies CD48 as a low affinity ligand for human CD2: divergence of CD2 ligands during the evolution of humans and mice.

1993 • 122 citations

High level expression in Chinese hamster ovary cells of soluble forms of CD4 T lymphocyte glycoprotein including glycosylation variants.

1990 • 121 citations

Three-dimensional solution structure of the extracellular region of the complement regulatory protein CD59, a new cell-surface protein domain related to snake venom neurotoxins.

1994 • 118 citations

Affinity and kinetic analysis of the interaction of the cell adhesion molecules rat CD2 and CD48.

1993 • 115 citations

The cell surface molecule recognized by the erythrocyte receptor of T lymphocytes. Identification and partial characterization using a monoclonal antibody.

1985 • 105 citations

CD59 molecule: A second ligand for CD2 in T cell adhesion

1992 • 98 citations

Expression of the Blast-1 activation/adhesion molecule and its identification as CD48.

1991 • 96 citations

T‐Lymphocyte Activation: The Biology and Function of CD2 and CD4

1989 • 87 citations

Correlation of CD2 binding and functional properties of multimeric and monomeric lymphocyte function-associated antigen 3.

1989 • 85 citations

Purification and Chemical Characterisation of Membrane Glycoproteins from Rat Thymocytes and Brain, Recognised by Monoclonal Antibody MRC OX 2

1982 • 80 citations

A 19-kDa human erythrocyte molecule H19 is involved in rosettes, present on nucleated cells, and required for T cell activation. Comparison of the roles of H19 and LFA-3 molecules in T cell activation.

1989 • 77 citations

The MRC OX-45 antigen of rat leukocytes and endothelium is in a subset of the immunoglobulin superfamily with CD2, LFA-3 and carcinoembryonic antigens.

1988 • 74 citations

Antibody and HIV-1 gpl20 recognition of CD4 undermines the concept of mimicry between antibodies and receptors

1992 • 74 citations

The NH₂‐terminal domain of rat CD2 binds rat CD48 with a low affinity and binding does not require glycosylation of CD2

1993 • 66 citations

Structure of the glycosylated adhesion domain of human T lymphocyte glycoprotein CD2

1993 • 66 citations

Structural and binding analysis of a two domain extracellular CD2 molecule.

1989 • 61 citations

Interactions in the Fourth Dimension

1992 • 52 citations

CD48 is a low affinity ligand for human CD2.

1993 • 42 citations

The human LFA-3 gene is located at the same chromosome band as the gene for its receptor CD2

1988 • 40 citations

Mutational analysis of the CD2/CD58 interaction: the binding site for CD58 lies on one face of the first domain of human CD2.

1993 • 39 citations

Structural and functional epitopes of the human adhesion receptor CD58 (LFA‐3)

1992 • 38 citations

MRC OX-45 antigen: A leucocyte/endothelium rat membrane glycoprotein of 45,000 molecular weight

1986 • 35 citations

Emergence of the LY-6 superfamily of GPI-anchored molecules

1991 • 26 citations

Adhesion domain of human T11 (CD2) is encoded by a single exon.

1988 • 19 citations

The human leucocyte antigen CD48 (MEM-102) is closely related to the activation marker Blast-1

1991 • 18 citations

Mouse LFA‐3 studied with chimeric soluble CD2 shows preferential expression on lymphoid cells

1991 • 17 citations

Analysis of the structure and interactions of CD2

1993 • 16 citations

Structural analysis of the CD2 T lymphocyte antigen by site-directed mutagenesis to introduce a disulphide bond into domain 1

1993 • 10 citations