An Oxidative Stress-Mediated Death Pathway in Irradiated Human Leukemia Cells Mapped Using Multilaser Flow Cytometry

Early redistribution of plasma membrane phosphatidylserine is a general feature of apoptosis regardless of the initiating stimulus: inhibition by overexpression of Bcl-2 and Abl.

1995 • 2,877 citations

A model for p53-induced apoptosis

1997 • 2,502 citations

The proto-oncogene Bcl-2 and its role in regulating apoptosis

1997 • 1,768 citations

BAX-induced cell death may not require interleukin 1β-converting enzyme-like proteases

1996 • 911 citations

Superoxide in Apoptosis

1998 • 773 citations

The Central Executioner of Apoptosis: Multiple Connections between Protease Activation and Mitochondria in Fas/APO-1/CD95- and Ceramide-induced Apoptosis

1997 • 625 citations

Oxidative Stress, Thiol Reagents, and Membrane Potential Modulate the Mitochondrial Permeability Transition by Affecting Nucleotide Binding to the Adenine Nucleotide Translocase

1997 • 588 citations

Studies on the inhibitory mechanism of iodonium compounds with special reference to neutrophil NADPH oxidase

1993 • 586 citations

The voltage sensor of the mitochondrial permeability transition pore is tuned by the oxidation-reduction state of vicinal thiols. Increase of the gating potential by oxidants and its reversal by reducing agents

1994 • 527 citations

The stress-activated protein kinase pathway mediates cell death following injury induced by cis-platinum, UV irradiation or heat

1996 • 457 citations

p53 gene mutations are associated with decreased sensitivity of human lymphoma cells to DNA damaging agents.

1994 • 410 citations

Glutathione depletion is an early and calcium elevation is a late event of thymocyte apoptosis.

1997 • 309 citations

Overexpression of Bcl-X(L) inhibits Ara-C-induced mitochondrial loss of cytochrome c and other perturbations that activate the molecular cascade of apoptosis.

1997 • 259 citations

Hypersensitivity of human testicular tumors to etoposide-induced apoptosis is associated with functional p53 and a high Bax:Bcl-2 ratio.

1996 • 257 citations

Mitochondrial implication in apoptosis. Towards an endosymbiont hypothesis of apoptosis evolution

1997 • 251 citations

Evaluation of methods for measuring cellular glutathione content using flow cytometry

1994 • 245 citations

Regulation of DNA damage-induced apoptosis by the c-Abl tyrosine kinase

1997 • 191 citations

The ICE family of cysteine proteases as effectors of cell death.

1996 • 158 citations

Translational regulation of human p53 gene expression.

1996 • 139 citations

Mutation of the p53 gene in human acute myelogenous leukemia

1991 • 128 citations

Resistance to radiation-induced apoptosis in Burkitt's lymphoma cells is associated with defective ceramide signaling.

1997 • 126 citations

Relationships between the mitochondrial permeability transition and oxidative stress during ara-C toxicity.

1997 • 105 citations

Decreasing the apoptotic threshold of tumor cells through protein kinase C inhibition and sphingomyelinase activation increases tumor killing by ionizing radiation.

1997 • 103 citations

Direct evidence for the participation of bcl-2 in the regulation by retinoic acid of the Ara-C sensitivity of leukemic stem cells.

1995 • 71 citations

p53 in life and death.

1996 • 62 citations

Generation of reactive oxygen intermediates after treatment of blasts of acute myeloblastic leukemia with cytosine arabinoside: role of bcl-2.

1996 • 59 citations

Modifiers of Radiation-Induced Apoptosis

1993 • 51 citations