Thioredoxin Is Transcriptionally Induced upon Activation of Heat Shock Factor 2

THE HEAT-SHOCK PROTEINS

1988 • 5,214 citations

THIOREDOXIN

1985 • 1,885 citations

Thioredoxin and Glutaredoxin Systems

1989 • 1,778 citations

Cells in Stress: Transcriptional Activation of Heat Shock Genes

1993 • 1,429 citations

Isolation and Characterization of Full-Length cDNA Clones for Human α-, β-, and γ-Actin mRNAs: Skeletal but Not Cytoplasmic Actins Have an Amino-Terminal Cysteine that Is Subsequently Removed

1983 • 1,220 citations

Heat Shock Transcription Factors: Structure and Regulation

1995 • 1,179 citations

The metabolism of menadione (2-methyl-1,4-naphthoquinone) by isolated hepatocytes. A study of the implications of oxidative stress in intact cells.

1982 • 893 citations

Activation of heat shock gene transcription by heat shock factor 1 involves oligomerization, acquisition of DNA-binding activity, and nuclear localization and can occur in the absence of stress.

1993 • 879 citations

AP-1 transcriptional activity is regulated by a direct association between thioredoxin and Ref-1

1997 • 836 citations

Thiordoxin regulates the DNA binding activity of NF-χB by reduction of a disulphid bond involving cysteine 62

1992 • 825 citations

A scheme for the colorimetric determination of microgram amounts of thiols

1958 • 754 citations

Stress proteins in biology and medicine

1990 • 731 citations

Identification and characterization of Ref-1, a nuclear protein that facilitates AP-1 DNA-binding activity.

1992 • 702 citations

Distinct effects of thioredoxin and antioxidants onthe activation of transcription factors NF-kappa B and AP-1.

1994 • 694 citations

Protein traffic on the heat shock promoter: Parking, stalling, and trucking along

1993 • 507 citations

Stress proteins in biology and medicine

1990 • 502 citations

Regulation of Heat Shock Factor Trimer Formation: Role of a Conserved Leucine Zipper

1993 • 486 citations

Structure and expression of the human gene encoding major heat shock protein HSP70.

1985 • 461 citations

Activation of human heat shock genes is accompanied by oligomerization, modification, and rapid translocation of heat shock transcription factor HSF1.

1993 • 455 citations

Coordinate changes in heat shock element-binding activity and HSP70 gene transcription rates in human cells.

1988 • 407 citations

HSF4, a New Member of the Human Heat Shock Factor Family Which Lacks Properties of a Transcriptional Activator

1997 • 350 citations

Stress-Inducible Cellular Responses

1995 • 337 citations

Thioredoxin and thioredoxin reductase gene expression in human tumors and cell lines, and the effects of serum stimulation and hypoxia.

1996 • 309 citations

Multiple functions ofDrosophilaheat shock transcription factorin vivo

1997 • 300 citations

Adult T-cell leukemia-derived factor/thioredoxin, produced by both human T-lymphotropic virus type I- and Epstein-Barr virus-transformed lymphocytes, acts as an autocrine growth factor and synergizes with interleukin 1 and interleukin 2.

1990 • 283 citations

Activation of Heat Shock Factor 2 during Hemin-Induced Differentiation of Human Erythroleukemia Cells

1992 • 281 citations

Human Heat Shock Factors 1 and 2 Are Differentially Activated and Can Synergistically Induce hsp70 Gene Transcription

1994 • 246 citations

Sequence and regulation of a gene encoding a human 89-kilodalton heat shock protein.

1989 • 241 citations

Cloning and expression of a cDNA for human thioredoxin.

1988 • 239 citations

Solution structure of human thioredoxin in a mixed disulfide intermediate complex with its target peptide from the transcription factor NFκB

1995 • 224 citations

RNA fingerprinting and differential display using arbitrarily primed PCR

1995 • 224 citations

Expression of Heat Shock Factor 2 in Mouse Testis: Potential Role as a Regulator of Heat-Shock Protein Gene Expression during Spermatogenesis1

1994 • 178 citations

Heat shock-induced interactions of heat shock transcription factor and the human hsp70 promoter examined by in vivo footprinting.

1991 • 159 citations

Cell growth stimulation by the redox protein thioredoxin occurs by a novel helper mechanism.

1995 • 147 citations

A Novel Promoter Sequence Is Involved in the Oxidative Stress-Induced Expression of the Adult T-Cell Leukemia-Derived Factor (ADF)/Human Thioredoxin (Trx) Gene

1996 • 145 citations

Expression and growth-promoting effect of adult t-cell leukemia-derived factor a human thioredoxin homologue in hepatocellular carcinoma

1992 • 145 citations

Dual regulation of heat-shock transcription factor (HSF) activation and DNA-binding activity by H2O2: role of thioredoxin

1996 • 141 citations

Function and regulation of heat shock factor 2 during mouse embryogenesis

1997 • 136 citations

Complex expression of murine heat shock transcription factors

1995 • 128 citations

Site-directed mutagenesis of active site cysteines in human thioredoxin produces competitive inhibitors of human thioredoxin reductase and elimination of mitogenic properties of thioredoxin.

1994 • 120 citations

Heat shock-induced translational control of HSP70 and globin synthesis in chicken reticulocytes.

1984 • 116 citations

Mouse Heat Shock Transcription Factors 1 and 2 Prefer a Trimeric Binding Site but Interact Differently with the HSP70 Heat Shock Element

1993 • 109 citations

RNA fingerprinting using arbitrarily primed PCR identifies differentially regulated RNAs in mink lung (Mv1Lu) cells growth arrested by transforming growth factor beta 1.

1993 • 104 citations

ADF, A Growth-Promoting Factor Derived from Adult T Cell Leukemia and Homologous to Thioredoxin: Involvement in Lymphocyte Immortalization by HTLV-I and EBV

1991 • 104 citations

Tissue-Dependent Expression of Heat Shock Factor 2 Isoforms with Distinct Transcriptional Activities

1995 • 96 citations

Heat Shock and Development

1991 • 86 citations

Characterization of constitutive HSF2 DNA-binding activity in mouse embryonal carcinoma cells.

1994 • 80 citations

Heat Shock Factor 2-like Activity in Mouse Blastocysts

1994 • 79 citations

Overexpression of HSF2-β Inhibits Hemin-induced Heat Shock Gene Expression and Erythroid Differentiation in K562 Cells

1997 • 45 citations

STRESS-INDUCIBLE CELLULAR RESPONSES

1997 • 41 citations

Lymphocyte transformation and thiol compounds: The role of ADF/thioredoxin as an endogenous reducing agent

1992 • 31 citations

Glutathione, cell proliferation, and 1,3-bis-(2-chloroethyl)-1-nitrosourea in K562 leukemia.

1993 • 28 citations

Potentiation of oxygen toxicity by menadione in Saccharomyces cerevisiae

1983 • 26 citations

Administration of Ethyol (amifostine) to a child with medulloblastoma to ameliorate hematological toxicity of high dose carboplatin

1996 • 20 citations