Multiple sorting pathways between the late Golgi and the vacuole in yeast

SNAP receptors implicated in vesicle targeting and fusion

1993 • 3,220 citations

Mechanisms of intracellular protein transport

1994 • 2,280 citations

A new vital stain for visualizing vacuolar membrane dynamics and endocytosis in yeast.

1995 • 1,352 citations

Protein sorting in Saccharomyces cerevisiae: isolation of mutants defective in the delivery and processing of multiple vacuolar hydrolases.

1988 • 977 citations

Phosphatidylinositol 3-Kinase Encoded by Yeast VPS 34 Gene Essential for Protein Sorting

1993 • 909 citations

The Exocyst is a multiprotein complex required for exocytosis in Saccharomyces cerevisiae.

1996 • 839 citations

Morphological classification of the yeast vacuolar protein sorting mutants: evidence for a prevacuolar compartment in class E vps mutants.

1992 • 832 citations

The diversity of Rab proteins in vesicle transport

1997 • 762 citations

Clathrin, Adaptors, and Sorting

1990 • 704 citations

Vesicle fusion from yeast to man

1994 • 635 citations

Does this have a familiar RING?

1996 • 632 citations

A Novel Rab5 GDP/GTP Exchange Factor Complexed to Rabaptin-5 Links Nucleotide Exchange to Effector Recruitment and Function

1997 • 586 citations

Early stages in the yeast secretory pathway are required for transport of carboxypeptidase Y to the vacuole

1982 • 579 citations

A fusion protein required for vesicle-mediated transport in both mammalian cells and yeast

1989 • 570 citations

A rab protein is required for the assembly of SNARE complexes in the docking of transport vesicles

1994 • 501 citations

The sorting receptor for yeast vacuolar carboxypeptidase Y is encoded by the VPS10 gene

1994 • 500 citations

Isolation and characterization of yeast mutants in the cytoplasm to vacuole protein targeting pathway.

1995 • 493 citations

Endosomal Localization of the Autoantigen EEA1 Is Mediated by a Zinc-binding FYVE Finger

1996 • 480 citations

Rabaptin-5 is a direct effector of the small GTPase Rab5 in endocytic membrane fusion

1995 • 476 citations

PROTEINASE MUTANTS OF SACCHAROMYCES CEREVISIAE

1977 • 460 citations

Homotypic vacuolar fusion mediated by t- and v-SNAREs

1997 • 457 citations

The AP-3 Adaptor Complex Is Essential for Cargo-Selective Transport to the Yeast Vacuole

1997 • 430 citations

Protein sorting in yeast: Mutants defective in vacuole biogenesis mislocalize vacuolar proteins into the late secretory pathway

1986 • 429 citations

Compartmental organization of Golgi-specific protein modification and vacuolar protein sorting events defined in a yeast sec18 (NSF) mutant.

1991 • 415 citations

Endosomal transport function in yeast requires a novel AAA-type ATPase, Vps4p

1997 • 412 citations

Organelle assembly in yeast: characterization of yeast mutants defective in vacuolar biogenesis and protein sorting.

1988 • 409 citations

Molecular Identification of a Novel Candidate Sorting Receptor Purified from Human Brain by Receptor-associated Protein Affinity Chromatography

1997 • 401 citations

Isolation of yeast mutants defective in protein targeting to the vacuole.

1986 • 394 citations

Endosome to Golgi Retrieval of the Vacuolar Protein Sorting Receptor, Vps10p, Requires the Function of the VPS29, VPS30, and VPS35 Gene Products

1997 • 393 citations

VPS27 controls vacuolar and endocytic traffic through a prevacuolar compartment in Saccharomyces cerevisiae.

1995 • 393 citations

AP-3: an adaptor-like protein complex with ubiquitous expression

1997 • 389 citations

Characterization of the Adaptor-related Protein Complex, AP-3

1997 • 369 citations

A Multispecificity Syntaxin Homologue, Vam3p, Essential for Autophagic and Biosynthetic Protein Transport to the Vacuole

1997 • 349 citations

A 200‐amino acid ATPase module in search of a basic function

1995 • 339 citations

Protein sorting by tyrosine-based signals: adapting to the Ys and wherefores

1997 • 329 citations

Protein sorting in yeast: The localization determinant of yeast vacuolar carboxypeptidase Y resides in the propeptide

1987 • 329 citations

GTPase activity of Rab5 acts as a timer for endocytic membrane fusion

1996 • 322 citations

Distinct sequence determinants direct intracellular sorting and modification of a yeast vacuolar protease

1987 • 312 citations

A conserved domain is present in different families of vesicular fusion proteins: A new superfamily

1997 • 308 citations

A Novel RING Finger Protein Complex Essential for a Late Step in Protein Transport to the Yeast Vacuole

1997 • 304 citations

SNAREs and NSF in targeted membrane fusion

1997 • 301 citations

Novel syntaxin homologue, Pep12p, required for the sorting of lumenal hydrolases to the lysosome-like vacuole in yeast.

1996 • 284 citations

Vps10p cycles between the late-Golgi and prevacuolar compartments in its function as the sorting receptor for multiple yeast vacuolar hydrolases.

1996 • 283 citations

Vacuole Biogenesis in Saccharomyces cerevisiae : Protein Transport Pathways to the Yeast Vacuole

1998 • 281 citations

Multilamellar endosome-like compartment accumulates in the yeast vps28 vacuolar protein sorting mutant.

1996 • 280 citations

Signal-mediated retrieval of a membrane protein from the Golgi to the ER in yeast.

1994 • 265 citations

The GTPase Ypt7p of Saccharomyces cerevisiae is required on both partner vacuoles for the homotypic fusion step of vacuole inheritance.

1995 • 265 citations

Endocytosis is required for the growth of vacuolar H(+)-ATPase-defective yeast: identification of six new END genes.

1994 • 258 citations

Two syntaxin homologues in the TGN/endosomal system of yeast

1998 • 258 citations

Characterization of genes required for protein sorting and vacuolar function in the yeast Saccharomyces cerevisiae.

1989 • 258 citations

Parallel secretory pathways to the cell surface in yeast.

1995 • 257 citations

Evidence for phosphatidylinositol 3-kinase as a regulator of endocytosis via activation of Rab5.

1995 • 255 citations

A novel adaptor-related protein complex.

1996 • 241 citations

Docking of Yeast Vacuoles Is Catalyzed by the Ras-like GTPase Ypt7p after Symmetric Priming by Sec18p (NSF)

1997 • 239 citations

Cis- and trans-acting functions required for endocytosis of the yeast pheromone receptors

1993 • 239 citations

Endocytosis in yeast: Evidence for the involvement of a small GTP-binding protein (Ypt7p)

1992 • 235 citations

A sorting nexin-1 homologue, Vps5p, forms a complex with Vps17p and is required for recycling the vacuolar protein-sorting receptor.

1997 • 219 citations

The Yeast Adaptor Protein Complex, AP-3, Is Essential for the Efficient Delivery of Alkaline Phosphatase by the Alternate Pathway to the Vacuole

1997 • 218 citations

Gene dosage-dependent secretion of yeast vacuolar carboxypeptidase Y.

1986 • 217 citations

The Yeast v-SNARE Vti1p Mediates Two Vesicle Transport Pathways through Interactions with the t-SNAREs Sed5p and Pep12p

1997 • 216 citations

Novel Golgi to vacuole delivery pathway in yeast: identification of a sorting determinant and required transport component

1997 • 215 citations

Role of three rab5-like GTPases, Ypt51p, Ypt52p, and Ypt53p, in the endocytic and vacuolar protein sorting pathways of yeast.

1994 • 211 citations

Mutation of a tyrosine localization signal in the cytosolic tail of yeast Kex2 protease disrupts Golgi retention and results in default transport to the vacuole.

1992 • 209 citations

A novel protein kinase homolog essential for protein sorting to the yeast lysosome-like vacuole

1991 • 204 citations

Physiological Regulation of Membrane Protein Sorting Late in the Secretory Pathway of Saccharomyces cerevisiae

1997 • 191 citations

VPS21 encodes a rab5-like GTP binding protein that is required for the sorting of yeast vacuolar proteins.

1994 • 190 citations

Genes for directing vacuolar morphogenesis in Saccharomyces cerevisiae. I. Isolation and characterization of two classes of vam mutants.

1992 • 188 citations

Receptor-Mediated Protein Sorting to the Vacuole in Yeast: Roles for a Protein Kinase, a Lipid Kinase and GTP-Binding Proteins

1995 • 184 citations

Golgi and vacuolar membrane proteins reach the vacuole in vps1 mutant yeast cells via the plasma membrane.

1995 • 183 citations

Membrane protein sorting in the yeast secretory pathway: evidence that the vacuole may be the default compartment.

1992 • 179 citations

A pathway for targeting soluble misfolded proteins to the yeast vacuole.

1996 • 178 citations

SOI1 Encodes a Novel, Conserved Protein That Promotes TGN–Endosomal Cycling of Kex2p and Other Membrane Proteins by Modulating the Function of Two TGN Localization Signals

1997 • 175 citations

Vam2/Vps41p and Vam6/Vps39p Are Components of a Protein Complex on the Vacuolar Membranes and Involved in the Vacuolar Assembly in the Yeast Saccharomyces cerevisiae

1997 • 171 citations

Ste5 RING-H2 Domain: Role in Ste4-Promoted Oligomerization for Yeast Pheromone Signaling

1997 • 169 citations

PairWise and SearchWise: Finding the Optimal Alignment in a Simultaneous Comparison of a Protein Profile against All DNA Translation Frames

1996 • 164 citations

Regulation of clathrin assembly and trimerization defined using recombinant triskelion hubs

1995 • 163 citations

Transmembrane domain-dependent sorting of proteins to the ER and plasma membrane in yeast

1997 • 161 citations

The yeast SEC17 gene product is functionally equivalent to mammalian alpha-SNAP protein.

1992 • 159 citations

The cytoplasmic tail domain of the vacuolar protein sorting receptor Vps10p and a subset of VPS gene products regulate receptor stability, function, and localization.

1995 • 157 citations

Folding and trimerization of clathrin subunits at the triskelion hub

1992 • 157 citations

A role for clathrin in the sorting of vacuolar proteins in the Golgi complex of yeast.

1992 • 157 citations

Altered expression of a novel adaptin leads to defective pigment granule biogenesis in the Drosophila eye color mutant garnet

1997 • 154 citations

A novel Sec18p/NSF-dependent complex required for Golgi-to-endosome transport in yeast.

1997 • 153 citations

The Membrane Protein Alkaline Phosphatase Is Delivered to the Vacuole by a Route That Is Distinct from the VPS-dependent Pathway

1997 • 153 citations

Yeast vacuolar proenzymes are sorted in the late Golgi complex and transported to the vacuole via a prevacuolar endosome-like compartment.

1993 • 152 citations

β-NAP, a cerebellar degeneration antigen, is a neuron-specific vesicle coat protein

1995 • 150 citations

Involvement of Ypt7p, a small GTPase, in traffic from late endosome to the vacuole in yeast

1993 • 150 citations

Mutations in the VPS45 gene, a SEC1 homologue, result in vacuolar protein sorting defects and accumulation of membrane vesicles

1994 • 150 citations

Membrane protein retention in the yeast Golgi apparatus: dipeptidyl aminopeptidase A is retained by a cytoplasmic signal containing aromatic residues.

1993 • 148 citations

Yeast carboxypeptidase Y vacuolar targeting signal is defined by four propeptide amino acids.

1990 • 147 citations

Suppressors of YCK-encoded yeast casein kinase 1deficiency define the four subunits of a novel clathrin AP-like complex

1997 • 147 citations

Selective and immediate effects of clathrin heavy chain mutations on Golgi membrane protein retention in Saccharomyces cerevisiae.

1992 • 147 citations

Localization of a yeast early Golgi mannosyltransferase, Och1p, involves retrograde transport.

1996 • 142 citations

Yeast Vps45p is a Sec1p-like protein required for the consumption of vacuole-targeted, post-Golgi transport vesicles.

1994 • 127 citations

The SLP1 gene of Saccharomyces cerevisiae is essential for vacuolar morphogenesis and function.

1990 • 123 citations

Characterization of yeast Vps33p, a protein required for vacuolar protein sorting and vacuole biogenesis.

1990 • 118 citations

Posttranslational processing of the prohormone-cleaving Kex2 protease in the Saccharomyces cerevisiae secretory pathway.

1991 • 118 citations

The yeast VPS5/GRD2 gene encodes a sorting nexin-1-like protein required for localizing membrane proteins to the late Golgi

1997 • 116 citations

Sortilin Is a Major Protein Component of Glut4-containing Vesicles

1997 • 114 citations

In vitro reactions of vacuole inheritance in Saccharomyces cerevisiae.

1992 • 113 citations

Molecular analysis of the yeast VPS3 gene and the role of its product in vacuolar protein sorting and vacuolar segregation during the cell cycle.

1990 • 112 citations

Characterization of a Novel Yeast SNARE Protein Implicated in Golgi Retrograde Traffic

1997 • 112 citations

Targeting of the yeast plasma membrane [H+]ATPase: a novel gene AST1 prevents mislocalization of mutant ATPase to the vacuole.

1995 • 111 citations

Detection of an intermediate compartment involved in transport of alpha-factor from the plasma membrane to the vacuole in yeast.

1990 • 111 citations

The sequence NPFXD defines a new class of endocytosis signal in Saccharomyces cerevisiae.

1996 • 109 citations

A genetic and structural analysis of the yeast Vps15 protein kinase: evidence for a direct role of Vps15p in vacuolar protein delivery.

1991 • 107 citations

Two Separate Signals Act Independently to Localize a Yeast Late Golgi Membrane Protein through a Combination of Retrieval and Retention

1997 • 104 citations

Novel Genes Involved in Endosomal Traffic in Yeast Revealed by Suppression of a Targeting-defective Plasma Membrane ATPase Mutant

1997 • 103 citations

The VPS16 gene product associates with a sedimentable protein complex and is essential for vacuolar protein sorting in yeast.

1993 • 103 citations

Vam3p, a new member of syntaxin related protein, is required for vacuolar assembly in the yeast Saccharomyces cerevisiae

1997 • 102 citations

Clathrin-dependent localization of alpha 1,3 mannosyltransferase to the Golgi complex of Saccharomyces cerevisiae.

1994 • 101 citations

Molecular characterization of VAC1, a gene required for vacuole inheritance and vacuole protein sorting.

1992 • 94 citations

Characterization of VPS41 , a gene required for vacuolar trafficking and high-affinity iron transport in yeast

1997 • 93 citations

Yeast Kex1p is a Golgi-associated membrane protein: deletions in a cytoplasmic targeting domain result in mislocalization to the vacuolar membrane.

1992 • 92 citations

The functioning of the yeast Golgi apparatus requires an ER protein encoded by ANP1, a member of a new family of genes affecting the secretory pathway.

1994 • 90 citations

A Yeast Protein Related to a Mammalian Ras-Binding Protein, Vps9p, Is Required for Localization of Vacuolar Proteins

1996 • 82 citations

A Novel RING Finger Protein, Vps8p, Functionally Interacts with the Small GTPase, Vps21p, to Facilitate Soluble Vacuolar Protein Localization

1996 • 77 citations

Localization and targeting of the Saccharomyces cerevisiae Kre2p/Mnt1p alpha 1,2-mannosyltransferase to a medial-Golgi compartment.

1995 • 74 citations

A Putative Zinc Finger Protein, Saccharomyces cerevisiae Vpsl8p, Affects Late Golgi Functions Required for Vacuolar Protein Sorting and Efficient α-Factor Prohormone Maturation

1991 • 74 citations

Characterization of the END1 gene required for vacuole biogenesis and gluconeogenic growth of budding yeast.

1989 • 72 citations

Isolation and characterization of PEP3, a gene required for vacuolar biogenesis in Saccharomyces cerevisiae.

1991 • 71 citations

Vacuolar biogenesis in yeast: Sorting out the sorting proteins

1995 • 69 citations

Traffic into the prevacuolar/endosomal compartment of Saccharomyces cerevisiae: A VPS45-dependent intracellular route and a VPS45-independent, endocytic route

1998 • 68 citations

Multiple Pathways for Vacuolar Sorting of Yeast Proteinase A

1996 • 61 citations

Protein Transport from the Cytoplasm into the Vacuole

1997 • 56 citations

Molecular characterisation of the deep orange (dor ) gene of Drosophila melanogaster

1997 • 56 citations

Genes for directing vacuolar morphogenesis in Saccharomyces cerevisiae. II. VAM7, a gene for regulating morphogenic assembly of the vacuoles.

1992 • 53 citations

Pep7p provides a novel protein that functions in vesicle-mediated transport between the yeast Golgi and endosome.

1997 • 46 citations

The effects of clathrin inactivation on localization of Kex2 protease are independent of the TGN localization signal in the cytosolic tail of Kex2p.

1996 • 45 citations

Isolation and characterization of PEP5, a gene essential for vacuolar biogenesis in Saccharomyces cerevisiae.

1990 • 43 citations

Clathrin domains involved in recognition by assembly protein AP-2.

1991 • 41 citations

Immunoisolation of Kex2p-containing organelles from yeast demonstrates colocalisation of three processing proteinases to a single Golgi compartment

1993 • 40 citations

vac2: a yeast mutant which distinguishes vacuole segregation from Golgi-to-vacuole protein targeting.

1991 • 40 citations

Recognition sites for clathrin-associated proteins AP-2 and AP-3 on clathrin triskelia.

1992 • 38 citations

A putative zinc finger protein, Saccharomyces cerevisiae Vps18p, affects late Golgi functions required for vacuolar protein sorting and efficient alpha-factor prohormone maturation.

1991 • 37 citations

Tail-specific antibodies that block return of 46,000 M(r) mannose 6-phosphate receptor to the trans-Golgi network

1993 • 28 citations