Modulation of Proteasomal Activity Required for the Generation of a Cytotoxic T Lymphocyte–defined Peptide Derived from the Tumor Antigen MAGE-3

Re-examination and further development of a precise and rapid dye method for measuring cell growth/cell kill

1989 • 3,477 citations

Inhibitors of the proteasome block the degradation of most cell proteins and the generation of peptides presented on MHC class I molecules

1994 • 2,480 citations

STRUCTURE AND FUNCTIONS OF THE 20S AND 26S PROTEASOMES

1996 • 2,408 citations

Structure of 20S proteasome from yeast at 2.4Å resolution

1997 • 2,211 citations

Inhibition of Proteasome Activities and Subunit-Specific Amino-Terminal Threonine Modification by Lactacystin

1995 • 1,601 citations

The Proteasome: Paradigm of a Self-Compartmentalizing Protease

1998 • 1,483 citations

A highly sensitive cell line, WEHI 164 clone 13, for measuring cytotoxic factor/tumor necrosis factor from human monocytes

1986 • 1,282 citations

MECHANISMS OF MHC CLASS I–RESTRICTED ANTIGEN PROCESSING

1998 • 1,017 citations

Human gene MAGE-3 codes for an antigen recognized on a melanoma by autologous cytolytic T lymphocytes.

1994 • 771 citations

The ubiquitin system

1997 • 541 citations

Identification, purification, and characterization of a protein activator (PA28) of the 20 S proteasome (macropain).

1992 • 439 citations

Purification of an 11 S regulator of the multicatalytic protease.

1992 • 384 citations

A peptide encoded by human gene MAGE‐3 and presented by HLA‐A2 induces cytolytic T lymphocytes that recognize tumor cells expressing MAGE‐3

1994 • 379 citations

Evidence for the presence of five distinct proteolytic components in the pituitary multicatalytic proteinase complex. Properties of two components cleaving bonds on the carboxyl side of branched chain and small neutral amino acids

1993 • 323 citations

Coordinated Dual Cleavages Induced by the Proteasome Regulator PA28 Lead to Dominant MHC Ligands

1996 • 287 citations

An inhibitor of HIV-1 protease modulates proteasome activity, antigen presentation, and T cell responses

1998 • 282 citations

A proteolytic system that compensates for loss of proteasome function

1998 • 271 citations

Two distinct proteolytic processes in the generation of a major histocompatibility complex class I-presented peptide

1997 • 267 citations

Contribution of Proteasomal β-Subunits to the Cleavage of Peptide Substrates Analyzed with Yeast Mutants

1998 • 266 citations

Identification, purification, and characterization of a high molecular weight, ATP-dependent activator (PA700) of the 20 S proteasome.

1994 • 238 citations

Direct isolation, phenotyping and cloning of low-frequency antigen-specific cytotoxic T lymphocytes from peripheral blood

1998 • 234 citations

Peptide antigen production by the proteasome: complexity provides efficiency

1996 • 228 citations

Homozygous deletions that simultaneously eliminate expressions of class I and class II antigens of EBV-transformed B-lymphoblastoid cells. I. Reduced proliferative responses of autologous and allogeneic T cells to mutant cells that have decreased expression of class II antigens

1984 • 187 citations

Intracellular distribution of proteasomes

1998 • 161 citations

Identification and intracellular location of MAGE-3 gene product.

1995 • 140 citations

Genes encoded in the major histocompatibility complex affecting the generation of peptides for TAP transport

1995 • 129 citations

Subunit arrangement in the human 20S proteasome

1997 • 121 citations

MHC class I-associated peptides produced from endogenous gene products with vastly different efficiencies.

1997 • 110 citations

The generation of MHC class I-associated peptides is only partially inhibited by proteasome inhibitors: involvement of nonproteasomal cytosolic proteases in antigen processing?

1997 • 108 citations

The proteolytic fragments generated by vertebrate proteasomes: structural relationships to major histocompatibility complex class I binding peptides.

1996 • 108 citations

A peptide encoded by the human MAGE3 gene and presented by HLA-1344 induces cytolytic T lymphocytes that recognize tumor cells expressing MAGE3

1996 • 107 citations

Two Listeria monocytogenes CTL epitopes are processed from the same antigen with different efficiencies.

1996 • 99 citations

Using ubiquitin to follow the metabolic fate of a protein.

1996 • 97 citations

Effects of Major‐Histocompatibility‐Complex‐Encoded Subunits on the Peptidase and Proteolytic Activities of Human 20S Proteasomes

1996 • 95 citations

Dissociation of Proteasomal Degradation of Biosynthesized Viral Proteins from Generation of MHC Class I-Associated Antigenic Peptides

1998 • 64 citations

Analysis of MAGE-3-specific cytolytic T lymphocytes in human leukocyte antigen-A2 melanoma patients.

1997 • 62 citations

Selective involvement of proteasomes and cysteine proteases in MHC class I antigen presentation.

1997 • 52 citations

Regulation of class I-restricted epitope processing by local or distal flanking sequence.

1997 • 47 citations

Proteasomes generate in vitro a natural peptide of influenza-A nucleoprotein functional in HLA-B27 antigen assembly

1996 • 9 citations

Probing the specificity of the bovine pituitary multicatalytic proteinase complex by inhibitors, activators, and by chemical modification.

1991 • 7 citations