Potential Immunocompetence of Proteolytic Fragments Produced by Proteasomes before Evolution of the Vertebrate Immune System

Inhibitors of the proteasome block the degradation of most cell proteins and the generation of peptides presented on MHC class I molecules

1994 • 2,480 citations

Allele-specific motifs revealed by sequencing of self-peptides eluted from MHC molecules

1991 • 2,447 citations

STRUCTURE AND FUNCTIONS OF THE 20S AND 26S PROTEASOMES

1996 • 2,408 citations

MHC ligands and peptide motifs: first listing

1995 • 1,674 citations

Inhibition of Proteasome Activities and Subunit-Specific Amino-Terminal Threonine Modification by Lactacystin

1995 • 1,601 citations

Crystal Structure of the 20 S Proteasome from the Archaeon T. acidophilum at 3.4 Å Resolution

1995 • 1,513 citations

Structural Analysis of Substrate Binding by the Molecular Chaperone DnaK

1996 • 1,247 citations

The Three-Dimensional Structure of Peptide-MHC Complexes

1995 • 817 citations

The structure of HLA-B27 reveals nonamer self-peptides bound in an extended conformation

1991 • 687 citations

ANTIGEN PROCESSING AND PRESENTATION BY THE CLASS I MAJOR HISTOCOMPATIBILITY COMPLEX

1996 • 613 citations

Heat shock proteins transfer peptides during antigen processing and CTL priming

1994 • 580 citations

γ-Interferon and expression of MHC genes regulate peptide hydrolysis by proteasomes

1993 • 572 citations

MHC Class I Expression in Mice Lacking the Proteasome Subunit LMP-7

1994 • 520 citations

Exact prediction of a natural T cell epitope

1991 • 455 citations

MHC-linked LMP gene products specifically alter peptidase activities of the proteasome

1993 • 453 citations

Altered peptidase and viral-specific T cell response in LMP2 mutant mice

1994 • 450 citations

Identification, purification, and characterization of a protein activator (PA28) of the 20 S proteasome (macropain).

1992 • 439 citations

Purification of an 11 S regulator of the multicatalytic protease.

1992 • 384 citations

Interferon-γ Induces Different Subunit Organizations and Functional Diversity of Proteasomes1

1994 • 371 citations

A role for the proteasome regulator PA28α in antigen presentation

1996 • 341 citations

Selectivity of MHC-encoded peptide transporters from human, mouse and rat

1994 • 339 citations

Interferon gamma stimulation modulates the proteolytic activity and cleavage site preference of 20S mouse proteasomes.

1994 • 314 citations

Coordinated Dual Cleavages Induced by the Proteasome Regulator PA28 Lead to Dominant MHC Ligands

1996 • 287 citations

How MHC Class II Molecules Acquire Peptide Cargo: Biosynthesis and Trafficking through the Endocytic Pathway

1995 • 280 citations

Proteasome subunits encoded by the major histocompatibility complex are not essential for antigen presentation

1992 • 250 citations

New insights into V(D)J recombination and its role in the evolution of the immune system

1995 • 246 citations

The Interferon-γ-inducible 11 S Regulator (PA28) and the LMP2/LMP7 Subunits Govern the Peptide Production by the 20 S Proteasome in Vitro

1995 • 233 citations

Peptide antigen production by the proteasome: complexity provides efficiency

1996 • 228 citations

Contribution of proteasome-mediated proteolysis to the hierarchy of epitopes presented by major histocompatibility complex class I molecules

1995 • 225 citations

Determinant selection of major histocompatibility complex class I-restricted antigenic peptides is explained by class I-peptide affinity and is strongly influenced by nondominant anchor residues.

1994 • 216 citations

Proteasome subunits encoded in the MHC are not generally required for the processing of peptides bound by MHC class I molecules

1992 • 215 citations

Cooperative interaction of B lymphocytes with antigen-specific helper T lymphocytes is MHC restricted

1981 • 207 citations

Primary structures of two homologous subunits of PA28, a γ‐interferon‐inducible protein activator of the 20S proteasome

1995 • 196 citations

A hypothetical model for the peptide binding domain of hsp70 based on the peptide binding domain of HLA.

1991 • 191 citations

The first characterization of a eubacterial proteasome: the 20S complex of Rhodococcus

1995 • 186 citations

Existence of a molecular ruler in proteasomes suggested by analysis of degradation products

1994 • 179 citations

Human transporters associated with antigen processing possess a promiscuous peptide-binding site

1994 • 178 citations

Molecular cloning and expression of a gamma-interferon-inducible activator of the multicatalytic protease.

1994 • 175 citations

Evolutionary conservation of MHC class I and class II molecules—different yet the same

1994 • 168 citations

Incorporation of major histocompatibility complex – encoded subunits LMP2 and LMP7 changes the quality of the 20S proteasome polypeptide processing products independent of interferon‐γ

1995 • 167 citations

PA28 Activator Protein Forms Regulatory Caps on Proteasome Stacked Rings

1994 • 167 citations

Paralogy Mapping: Identification of a Region in the Human MHC Triplicated onto Human Chromosomes 1 and 9 Allows the Prediction and Isolation of NovelPBXandNOTCHLoci

1996 • 152 citations

Chromosomal duplication and the emergence of the adaptive immune system

1997 • 151 citations

Which came first, MHC class I or class II?

1991 • 132 citations

The proteasome‐specific inhibitor lactacystin blocks presentation of cytotoxic T lymphocyte epitopes in human and murine cells

1997 • 129 citations

Purification and Characterization of the Heat Shock Proteins HslV and HslU That Form a New ATP-dependent Protease in

1996 • 119 citations

The proteolytic fragments generated by vertebrate proteasomes: structural relationships to major histocompatibility complex class I binding peptides.

1996 • 108 citations

Effects of Major‐Histocompatibility‐Complex‐Encoded Subunits on the Peptidase and Proteolytic Activities of Human 20S Proteasomes

1996 • 95 citations

MHC-encoded proteasome subunits LMP2 and LMP7 are not required for efficient antigen presentation.

1994 • 94 citations

The LMP antigens: A stable MHC-controlled multisubunit protein complex

1986 • 93 citations

The Peptide-Binding Domain of the Chaperone Protein Hsc70 Has an Unusual Secondary Structure Topology

1995 • 91 citations

Expression of functional Thermoplasma acidophilum proteasomes in Escherichia coli

1992 • 89 citations

Effects of interferon gamma and major histocompatibility complex-encoded subunits on peptidase activities of human multicatalytic proteases.

1995 • 80 citations

How Selective Is the Transporter Associated with Antigen Processing?

1996 • 72 citations

Isolation of low molecular mass polypeptide complementary DNA clones from primitive vertebrates. Implications for the origin of MHC class I-restricted antigen presentation.

1996 • 69 citations

Binding of Viral Antigens to Major Histocompatibility Complex Class I H-2Db Molecules Is Controlled by Dominant Negative Elements at Peptide Non-anchor Residues

1996 • 62 citations

Proteasome and its novel endogeneous activator in human platelets

1991 • 49 citations

Human lymphoblast and erythrocyte multicatalytic proteases: differential peptidase activities and responses to the 11S regulator

1995 • 43 citations

Presentation of viral antigens restricted by H‐2K^b, D^b or K^d in proteasome subunit LMP2‐and LMP7‐deficient cells

1994 • 38 citations

Self peptides bound by HLA class I molecules are derived from highly conserved regions of a set of evolutionarily conserved proteins

1995 • 37 citations

Archaebacterial and eukaryotic proteasomes prefer different sites in cleaving gonadotropin-releasing hormone

1995 • 21 citations

Peptide selection for presentation by HLA class I: A role for the human transporter associated with antigen processing?

1996 • 18 citations

A prominent natural H-2 Kd ligand is derived from protein tyrosine kinase JAK1

1993 • 15 citations

Cleavage Specificity and Inhibition Profile of Proteasome Isolated from the Cytosol of Xenopus Oocyte1

1993 • 5 citations